ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa03410
Name Base excision repair
Description  Base excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair initiated by lesion-specific DNA glycosylases and completed by either of the two sub-pathways: short-patch BER where only one nucleotide is replaced and long-patch BER where 2-13 nucleotides are replaced. Each sub-pathway of BER relies on the formation of protein complexes that assemble at the site of the DNA lesion and facilitate repair in a coordinated fashion. This process of complex formation appears to provide an increase in specificity and efficiency to the BER pathway, thereby facilitating the maintenance of genome integrity by preventing the accumulation of highly toxic repair intermediates.
No. of Genes in ADHDgene  5
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 5)

Literature-origin genes (count: 0)

Genes from other sources Help(count: 5)

Approved Symbol Approved Name Location Source
POLE polymerase (DNA directed), epsilon 12q24.3 Mapped by CNV
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 11q14 Mapped by significant region
POLD4 polymerase (DNA-directed), delta 4 11q13 Mapped by significant region
POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit) 9q33 Mapped by significant region
FEN1 flap structure-specific endonuclease 1 11q12 Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014