ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Other Variant Report

Basic Info

Name	SNAP25_5'-UTR_(ATTT)n
Type	microsatellite
Location	5' UTR; between the 5' UTR and the first transcribed exon of the SNAP25 gene
Length of Repeat Unit	4bp
Related Gene	SNAP25
No. of Study	4 (significant: 2; non-significant 2; trend: 0)

Variant related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Mill J, 2002		allele 2, allele 5	case-control allele test (2-tailed): overall P-value=0.08, P...... case-control allele test (2-tailed): overall P-value=0.08, P-value=0.01 (OR=0.54) for allele 2, P-value=0.06 (OR=1.34) for allele 5, P-value>0.1 for the rest 5 alleles; family-based TDT: P-value=0.05 for allele 2, P-value=0.04 for allele 5 More...	a near significant difference was found between all probands...... a near significant difference was found between all probands and controls. Using CLUMP, a significant difference between probands and controls was found when allele 2 was taken compared to the rest clumped together. Results from TDT analysis on allele 2 and allele 5 showed that both are marginally significant. More...	Significant
Mill J, 2004 (b)			allelic TDT P-value=0.01, X²=14.80, 5df; HHRR P-v...... allelic TDT P-value=0.01, X²=14.80, 5df; HHRR P-value=0.01, X²=15.07, 5df; PDT P-value=0.005, X²=16.56, 5df; TRANSMIT P-value=0.001, X²=21.66, 5df in parental samples. maternal TDT X²=6.18, 5 df, P-value=0.29; paternal TDT X²=15.13, 5 df, P-value=0.01 More...	evidence for association using TDT, HHRR, PDT, and TRANSMIT ...... evidence for association using TDT, HHRR, PDT, and TRANSMIT analyses was found; was more significantly associated when paternal transmissions were analysed compared to maternal transmissions More...	Significant
Bobb AJ, 2005			allelic TDT P-value=0.88, OR=0.99 in case-control analysis; ...... allelic TDT P-value=0.88, OR=0.99 in case-control analysis; allelic TDT P-value=0.31 in family-based analysis More...	non-significant association non-significant association	Non-significant
Zhang HY, 2011			P-value=0.2790, X² (df=13)=15.468 P-value=0.2790, X² (df=13)=15.468	showed a non-significant association with ADHD showed a non-significant association with ADHD	Non-significant