ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SORCS3
Symbol Alias	KIAA1059, SORCS
Approved Name	sortilin-related VPS10 domain containing receptor 3
Location	10q23-q25
Position	chr10:106400859-107024993, +
External Links	HGNC: 16699 Entrez Gene: 22986 Ensembl: ENSG00000156395 UCSC: uc001kyi.1
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by CNV

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lionel, A. C., 2011	In one male ADHD proband (30600.3) of a second family, a pair of adjacent de novo CNVs at 10q25.1 duplicated regions of sizes 242 and 318kb, overlapping the genes SORCS3 and SORCS1 respectively.	Trend

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Lionel[2011]_2	chr10:0-0 (NCBI36 / hg18)	242	10q25.1	Gain	D

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008188	neuropeptide receptor activity	Molecular Function	NAS[11499680]	3
GO:0007218	neuropeptide signaling pathway	Biological Process	NAS[11499680]	17
GO:0016021	integral to membrane	Cellular Component		845
GO:0016020	membrane	Cellular Component	NAS[11499680]	139

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SORCS3 (count: 0)

Genes shared at least 2 KEGG pathways with SORCS3 (count: 0)

View in gBrowse

Region: chr10:106400859..107024993 View in gBrowse