ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Study Report

Basic Info

Reference	Yang L, 201323728934
Citation	Yang L, Neale BM, Liu L, Lee SH, Wray NR, Ji N, Li H, Qian Q, Wang D, Li J, Faraone SV, Wang Y, Psychiatric GCAS, Doyle AE, Reif A, Rothenberger A, Franke B, Sonuga-Barke EJ, Steinhausen HC, Buitelaar JK, Kuntsi J, Biederman J, Lesch KP, Kent L, Asherson P, Oades RD, Loo SK, Nelson SF, Faraone SV, Smalley SL, Banaschewski T, Arias Vasquez A, Todorov A, Charach A, Miranda A, Warnke A, Thapar A, Neale BM, Cormand B, Freitag C, Mick E, Mulas F, Middleton F, HakonarsonHakonarson H, Palmason H, Schafer H, Roeyers H, McGough JJ, Romanos J, Crosbie J, Meyer J, Ramos-Quiroga JA, Sergeant J, Elia J, Langely K, Nisenbaum L, Romanos M, Daly MJ, Ribases M, Gill M, O'Donovan M, Owen M, Casas M, Bayes M, Lambregts-Rommelse N, Williams N, Holmans P, Anney RJ, Ebstein RP, Schachar R, Medland SE, Ripke S, Walitza S, Nguyen TT, Renner TJ, Hu X (2013) Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants. Am J Med Genet B Neuropsychiatr Genet 162B: 419-30. doi: 10.1002/ajmg.b.32169
Study Design	case-control
Study Type	GWAS and CNV anaysis
Sample Size	1040 cases and 963 controls.
Predominant Ethnicity	Asian
Population	China
Gender	876 males and 164 females in case sample, 608 males and 355 females in control sample
Age Group	Children/Adolescents : mean age of 9.2 years,SD=2.4 for cases samples;mean age of 15.4 years,SD=8.8 for controls

Detail Info

Summary	We did not find genome-wide significance for single SNPs but did find an increased burden of large, rare CNVs in the ADHD sample(p=0.038).The INRICH, DAPPLE, and GREAT analyses implicated several gene ontology cellular components, including neuron projections and synaptic components, which are consistent with a neurodevelopmental.pathophysiology for ADHD. This study suggested the genetic architecture of ADHD comprises both commonandrare variants. Somecommoncausal variants are likely to be shared between Han Chinese and Caucasians. Complex neurodevelopmental networks may underlie ADHD¡¯s etiology.
Total Sample	The sample consists of 680 (65.4%) ADHD combined type and 360 (34.6%) inattentive type. The comorbidities included oppositional de?ant disorder (ODD) in 380 patients (36.5%), conduct disorderin 58 (5.6%), and tic disorder in 167 (16.1%).
Sample Collection	Patients were recruited from the Child and Adolescent Psychiatric Outpatient Department of the Sixth Hospital, Peking University.
Diagnosis Description	All cases met DSM-IV ADHD diagnostic criteria. A clinical diagnosis was ?rst made by a senior child and adolescent psychiatrist based on the parent and teacher completed ADHD Rating Scale-IV (ADHD-RS-IV), and then con?rmed by semi-structured interview with the parents and child using the Chinese version of the Clinical Diagnostic Interview Scale. Those with major neurological disorders (e.g., epilepsy), schizophrenia, pervasive development disorder, and mental retardation (IQ < 70) were excluded.
Technique	Both cases and controls were genotyped using the Affymetrix6.0 array at CapitalBio Ltd. (Beijing) using the standard Affymetrix protocol. Samples of cases and controls were added in equal proportion to each chip to avoid batch effects. The Affymetrix 6.0 array included 906,600 SNP probes and 946,000 CNV probes. The SNP genotypes were called with BIRDSEED v2, while CNVs were called with Genotyping Console (GTC) 4.0 using default parameters.
Analysis Method	Data quality control and association analysis were performed using PLINK£¬To examine population strati?cation, we performed multi-dimensional scaling(MDS). Logistic regression was conducted to adjust the association P-value, using the 10 principal componentsfrom the MDS procedure as covariates.To investigate the contribution of common SNPs to variation in liability to ADHD, we estimated the SNP-heritability using GCTA.Pathway based analysis were done using 3 tools,INRICH,DAPPLE,and GREAT
Result Description	We did not ?nd genome-wide signi?cance for single SNPs(the lowest,p>1.0E-6), most of the SNP with p-value lower than 1.0E-5 were known to be involved in neurodevelopment. CNV association analysis found six regions nominally associated with ADHD (P < 0.05),but none of them survived genome-wide correction SNP-heritability was estimated to be 0.42 (standard error, 0.13, P= 0.0017) and the SNP-genetic correlation with European Ancestry ADHD samples was 0.39(SE 0.15, P=0.0072). The INRICH, DAPPLE, and GREAT analyses implicated several gene ontology cellular components, including neuron projections and synaptic components, which are consistent with a neurodevelopmental pathophysiology for ADHD. This study suggested the genetic architecture of ADHD comprises both commonandrare variants. Somecommoncausal variants are likely to be shared between Han Chinese and Caucasians. Complex neurodevelopmental networks may underlie ADHD¡¯s etiology

SNPs reported by this study (count: 88)

SNP	Statistical Values	Author Comments	Result of Statistical Analysis
rs9471398	P-value=0.0000563	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs9471400	P-value=0.0000446	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs9471401	P-value=0.0000601	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6971139	P-value=0.0000552	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7144821	P-value=0.0000448	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4580847	P-value=0.0000509	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12660870	P-value=0.0000676	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs9394717	P-value=0.0000537	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7753979	P-value=0.0000509	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4635724	P-value=0.0000509	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4921604	P-value=0.0000498	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7144797	P-value=0.000051	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4445677	P-value=0.0000881	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7978480	P-value=0.0000597	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs8142185	P-value=0.0000583	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12582885	P-value=0.0000583	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12434887	P-value=0.0000672	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs856627	P-value=0.0000779	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs952793	P-value=0.0000625	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12434842	P-value=0.0000634	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs17558117	P-value=0.0000778	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12378218	P-value=0.0000805	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs863127	P-value=0.000066	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12435212	P-value=0.0000898	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs10824051	P-value=0.0000893	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs2748276	P-value=0.0000923	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7149744	P-value=0.0000822	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs11000831	P-value=0.0000893	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1340048	P-value=0.0000932	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs17100008	P-value=0.0000938	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs17232800	P-value=0.00000286	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Trend
rs690378	P-value=0.0000855	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1704734	P-value=0.0000334	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs689193	P-value=0.0000306	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs676186	P-value=0.0000208	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs489710	P-value=0.0000385	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs2665375	P-value=0.000025	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7227628	P-value=0.0000123	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs301407	P-value=0.0000171	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs507533	P-value=0.000006	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Trend
rs4245040	P-value=0.0000185	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs301410	P-value=0.0000635	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs10892592	P-value=0.0000857	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4935750	P-value=0.0000443	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4936537	P-value=0.0000648	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs4570590	P-value=0.0000435	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs16828074	P-value=0.0000219	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7160641	P-value=0.0000244	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7149784	P-value=0.0000636	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7674977	P-value=0.0000285	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1877918	P-value=0.0000656	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs10015131	P-value=0.0000833	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1514977	P-value=0.0000811	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1514972	P-value=0.0000694	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6532592	P-value=0.0000993	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7662545	P-value=0.0000911	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs10132279	P-value=0.0000381	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6038589	P-value=0.0000391	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7012077	P-value=0.0000428	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs16889388	P-value=0.0000433	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs2802837	P-value=0.0000435	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs17160554	P-value=0.0000443	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs3812463	P-value=0.0000738	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6453417	P-value=0.00000994	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Trend
rs10512416	P-value=0.0000432	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs16880453	P-value=0.0000346	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1466445	P-value=0.0000864	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1979398	P-value=0.0000258	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs13317247	P-value=0.0000637	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs17712565	P-value=0.000056	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6469852	P-value=0.0000921	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6469849	P-value=0.0000738	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12053018	P-value=0.0000426	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs891585	P-value=0.0000867	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6713607	P-value=0.0000713	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs12466468	P-value=0.0000271	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs11692499	P-value=0.0000343	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6706295	P-value=0.0000631	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6597539	P-value=0.0000998	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1940028	P-value=0.0000474	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs6989791	P-value=0.0000973	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs10459109	P-value=0.0000971	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs17096738	P-value=0.0000749	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs7012857	P-value=0.0000604	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs1885303	P-value=0.0000954	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs722970	P-value=0.0000746	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs10998087	P-value=0.0000455	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant
rs2423037	P-value=0.0000555	The SNPs associated with P values of 1E-5 or lower The SNPs associated with P values of 1E-5 or lower	Non-significant

CNVs reported by this study (count: 6)

Name	Symbol in Literature	Type	Inheritance	Author Comments
CNV_Yang[2013]_3				Nominally associated with ADHD, but didn't survived genome-w...... Nominally associated with ADHD, but didn't survived genome-wide correction More...
CNV_Yang[2013]_2				Nominally associated with ADHD, but didn't survived genome-w...... Nominally associated with ADHD, but didn't survived genome-wide correction More...
CNV_Yang[2013]_1				Nominally associated with ADHD, but didn't survived genome-w...... Nominally associated with ADHD, but didn't survived genome-wide correction More...
CNV_Yang[2013]_6				Nominally associated with ADHD, but didn't survived genome-w...... Nominally associated with ADHD, but didn't survived genome-wide correction More...
CNV_Yang[2013]_5				Nominally associated with ADHD, but didn't survived genome-w...... Nominally associated with ADHD, but didn't survived genome-wide correction More...
CNV_Yang[2013]_4				Nominally associated with ADHD, but didn't survived genome-w...... Nominally associated with ADHD, but didn't survived genome-wide correction More...

Genes reported by this study (count: 14)

Gene	Statistical Values/Author Comments	Result of Statistical Analysis
NTM	Gene with smallest SNP P-value=0.0000474, no significant or ...... Gene with smallest SNP P-value=0.0000474, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
FLRT2	Gene with smallest SNP P-value=0.000056, no significant or T...... Gene with smallest SNP P-value=0.000056, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
TMEM132B	Gene with smallest SNP P-value=0.0000971, no significant or ...... Gene with smallest SNP P-value=0.0000971, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
ITGA1	Gene with smallest SNP P-value=0.0000258, no significant or ...... Gene with smallest SNP P-value=0.0000258, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
DSCC1	Gene with smallest SNP P-value=0.0000738, no significant or ...... Gene with smallest SNP P-value=0.0000738, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
RASSF2	Gene with smallest SNP P-value=0.0000555, no significant or ...... Gene with smallest SNP P-value=0.0000555, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
ARSB	Gene with smallest SNP P-value=0.00000994, indecated a trend...... Gene with smallest SNP P-value=0.00000994, indecated a trend association with ADHD. More...	Trend
GRM7	Gene with smallest SNP P-value=0.0000637, no significant or ...... Gene with smallest SNP P-value=0.0000637, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
PRKG1	Gene with smallest SNP P-value=0.0000455, no significant or ...... Gene with smallest SNP P-value=0.0000455, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
ZNF516	Gene with smallest SNP P-value=0.0000855, no significant or ...... Gene with smallest SNP P-value=0.0000855, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
MED27	Gene with smallest SNP P-value=0.0000432, no significant or ...... Gene with smallest SNP P-value=0.0000432, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
SLC38A1	Gene with smallest SNP P-value=0.0000746, no significant or ...... Gene with smallest SNP P-value=0.0000746, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
NYAP2	Gene with smallest SNP P-value=0.0000271, no significant or ...... Gene with smallest SNP P-value=0.0000271, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant
TAF2	Gene with smallest SNP P-value=0.0000973, no significant or ...... Gene with smallest SNP P-value=0.0000973, no significant or Trend associated SNP was mapped in this gene. More...	Non-significant