ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Kenar, A. N.,201323768104
Citation	Kenar AN, Edgunlu T, Herken H, Erdal ME (2013) Association of synapsin III gene with adult attention deficit hyperactivity disorder. DNA Cell Biol 32: 430-4. doi: 10.1089/dna.2012.1937
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size
Predominant Ethnicity	Turkish
Population	Turkish
Gender	The study group consisted of 61 women (43.9%) and 78 men (56.1%) and the control group consisted of 41 women (38.7%) and 65 men (61.3%).
Age Group	Adults : The mean age of the study group was 27.12 , SD= 9.77 and mean age of the control group was 27.86 , SD=7.88.

Detail Info

Summary	It was aimed to investigate the association of the synapsin III gene -196 G> A and -631 C>G polymorphisms that takes place in an encoding presynaptic protein, with adult attention deficit hyperactivity disorder (ADHD). One hundred thirty-nine patients having adult ADHD and 106 controls were included in the study. DNA samples were extracted from whole blood and genetic analyses were performed. A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group. No significant difference was determined between ADHD and synapsin III gene -196 G>A polymorphism. These polymorphisms were found not to be associated with subtypes of ADHD. It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD.
Total Sample	"A total of 139 patients between ages of 18 and 60, meeting DSM-IV criteria for adult ADHD were included in the study. All patients were recruited from the research center and were of Turkish origin.The control group consisted of 106 healthy subjects between ages of 18 and 60 without any history of neuropsychiatric disorder. They were also of Turkish origin. The control group did not have any clinically signi?cant organic disorders or mental retardation and control subjects were literate. The study group consisted of 61 women (43.9%) and 78 men (56.1%) and the control group consisted of 41 women (38.7%) and 65 men (61.3%).The mean age of the study group was 27.12 , SD= 9.77 and mean age of the control group was 27.86 , SD=7.88. Of the 139 patients with adult ADHD, 40 (28.8%) were diagnosed as predominantly inattentive type, 39 (28.1%) were
Sample Collection	A total of 139 patients between ages of 18 and 60, meeting DSM-IV criteria for adult ADHD were included in the study. All patients were recruited from the research center and were of Turkish origin. Patients were evaluated with the Wender-Utah Rating Scale (WURS) and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale. Patients who scored 36 points or more on the WURS and answered at least six of nine questions as two or three of ?rst and second parts of the Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale were diagnosed as ADHD. The control group consisted of 106 healthy subjects between ages of 18 and 60 without any history of neuropsychiatric disorder. They were also of Turkish origin. The control group did not have any clinically signi?cant organic disorders or mental retardation and control subjects were literate. The control group was also evaluated with the WURS and Adult ADHD Diagnosis and Evaluation Scale and, subjects who met adult ADHD criteria were excluded from the control group.
Diagnosis Description	Subjects meeting DSM-IV criteria for adult ADHD were included in the study. Patients were evaluated with the Wender-Utah Rating Scale (WURS) and Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale. Patients who scored 36 points or more on the WURS and answered at least six of nine questions as two or three of ?rst and second parts of the Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale were diagnosed as ADHD. The control group consisted of 106 healthy subjects between ages of 18 and 60 without any history of neuropsychiatric disorder. The control group did not have any clinically signi?cant organic disorders or mental retardation and control subjects were literate. The control group was also evaluated with the WURS and Adult ADHD Diagnosis and Evaluation Scale and, subjects who met adult ADHD criteria were excluded from the control group.Social demographic data form: A data sheet was developed by the researchers for studying the sociodemographic characteristics of study groups.Wender-Utah Rating Scale: sWURS was developed by Ward and Wender (McCann et al.,2000). Turkish validity and reliably of the WURS was established by Oncu et al. (2005) and the cutoff score point was 36.Adult ADD/ADHD DSM IV-Based Diagnostic Screening and Rating Scale: Adult ADHD Diagnosis and Evaluation Scale were developed by Turgay in 1995. It is a self-assessment scale and patients can complete the questionnaire after being duly informed. When developing the adult ADD/ADHD Scale, 18 symptoms of the diagnostic criteria in DSM-IV were reframed, so patients can understand them. Turkish validity and reliability was established by Gunay et al. (2006).

Other variant reported by this study (count: 2)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
SYN3 -196 G>A	G>A		allelic P-value=0.515; G/A genotypic P-value=0.610 allelic P-value=0.515; G/A genotypic P-value=0.610	No signi?cant difference was determined between the groups in the point of the synapsin III gene -196 G>A polymorphism.	Non-significant
SYN3 -631 C>G	C>G		allelic P-value=0.853;genotypic P-value =0.030 allelic P-value=0.853;genotypic P-value =0.030	A significant difference was determined between ADHD and synapsin III gene -631 C>G polymorphism compared to the control group.	Significant

Genes reported by this study (count: 1)