ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Kwon, H. J.,201323692268
Citation	Kwon HJ, Lim MH (2013) Association between dopamine Beta-hydroxylase gene polymorphisms and attention-deficit hyperactivity disorder in korean children. Genet Test Mol Biomarkers 17: 529-34. doi: 10.1089/gtmb.2013.0072
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	142 cases and 139 controls
Predominant Ethnicity	Mongloid
Population	Korean
Gender	The number of ADHD children was 142, including 101 boys (71.1%) and 41 girls (28.9%). The number of the children in the control group was 139, including 93 boys (66.9%) and 46 girls (33.1%).
Age Group	Children/Adults : The mean age of ADHD was 8.67,SD=0.84, the mean age of control groups was 8.65, SD=0.81.

Detail Info

Summary	The aim of the present study was to investigate the association between the genetic type and alleles for the dopamine beta-hydroxylase (DBH) gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with the Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 281 subjects; DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for the DBH polymorphism. The alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of the DBH gene polymorphism in the ADHD and control groups.
Total Sample	Subjects were excluded from the study if there was any evidence of conduct disorder, mood disorder, anxiety disorder,Tourette disorder, pervasive development disorder, mental re-tardation (IQ<70), and neurological disorders, including epilepsy. None of the children who participated in the study has ever undergone drug treatment before the evaluation. Subjects were included from our sample if they had a score over two standard deviations from the norm on the tests for ADS (T-score > 70). We excluded children with the high score of depressive symptoms and anxiety symptoms. Subjects with high anxiety scores (a Spielberger trait/state anxiety scale score > 47/49) on the Korean version of Spielberger trait-state anxiety scale for children were excluded, and subjects with high depression scores (Kovacs depression inventory score > 29) on Kovacs depression inventory for children were also excluded. In addition, a professional clinical psychologist performed a comprehensive psychological test, including an intelligence test, on each subject.
Sample Collection	A questionnaire was conducted with about 16,000 elementary school students in a city whose population is about 500,000 from September 2008 and August 2010. For the control group, 139 children in the same area were selected by matching the sex and age of the subjects in the patient group.
Diagnosis Description	For both of the patient and control groups, a clinical evaluation and the DSM-IV diagnosis were performed by a child psychiatrist.
Technique	The DBH SNP was genotyped by polymerase chain reaction (PCR). DBH rs1108580, rs1611115, and rs2519152 were genotyped by Illumina, Inc. (San Diego, CA) through the use of their Integrated Bead Array System.
Analysis Method	We performed independent t-tests for age, chi-square tests for sex, and chi-square tests to compare the results of the control group and the ADHD group through the frequency of the genotypes and alleles. SPSS PC software (version 15.0) was used for the statistical analysis, and the signi?cance level was set to the p-value being < 0.05.
Result Description	This study showed that there was a significant correlation among the frequencies of rs1611115 (odds ratio=0.64, 95% confidence interval=0.42-0.97, p=0.034) of the alleles of DBH, but the final conclusions are not definite.

SNPs reported by this study (count: 3)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs1108580	A/G		allelic chi-square tests, P-value=0.149 (OR=1.47; 95%CI=0.87-2.48; X²=1.44); genotypic chi-square tests, P-value=0.170 (OR=1.50; 95%CI=0.84-2.67; X²=1.37).	No signi?cant correlation was found in this study. No signi?cant correlation was found in this study.	Non-significant
rs1611115	C/T		allelic chi-square tests, P-value=0.034 (OR=0.64; 95%CI=0.42-0.97; X²=2.11); genotypic chi-square tests, P-value=0.029 (OR=0.58; 95%CI=0.35-0.95; X²=2.18).	There was a signi?cant correlation among the frequencies of ...... There was a signi?cant correlation among the frequencies of rs1611115 of the alleles of DBH, but the ?nal conclusions are not de?nite. Follow-up studies with larger patient or pure subgroups are expected. More...	Significant
rs2519152	A/G		allelic chi-square tests, P-value=0.134 (OR=1.47; 95%CI=0.89-2.41; X²=1.50); genotypic chi-square tests, P-value=0.055 (OR=1.78; 95%CI=0.99-3.19; X²=1.92).	No signi?cant correlation was found in this study. No signi?cant correlation was found in this study.	Non-significant

Genes reported by this study (count: 1)