Meta-analysis Report
Basic Info
| Reference |
Ogdie MN, 200616205734
|
| Citation |
Ogdie M. N., Bakker S. C., Fisher S. E., Francks C., Yang M. H., Cantor R. M., Loo S. K., van der Meulen E., Pearson P., Buitelaar J., Monaco A., Nelson S. F., Sinke R. J. and Smalley S. L. (2006) "Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13." Mol Psychiatry, 11(1): 5-8.
|
| Study Type |
Genome-wide linkage study |
| Summary |
Genome scan analyses and fine mapping investigations in the UCLA sample support significant linkage in three regions: 6q12 (MLS 3.30), 16p13 (MLS 3.73), and 17p11 (MLS 3.63), while the Utrecht two-stage genome scan supports significant linkage in two regions: 7p13 (MLS 3.04) and 15q15 (MLS 3.54). Both studies had lower linkage signals (1
|
Detail Info
| Samples |
Genome scan analyses and fine mapping investiga-tions in the UCLA sample (Ogdie MN et al., 2004), the Utrecht two-stage genome scan (Bakker SC et al., 2003). In the pooled analyses the ASPs were restricted to only the ADHD ASPs (excluding autistic spectrum disorder), yielding a total collection of 424 ASPs. |
| Statistic Method |
First, they estimate linkage evidence across the whole genome using the pooled sample and empiric P-values generated by simulations (i.e. generating empiric P-values based on 1000 replicates per chromosome using the exact marker information from the individual scans; for methods, see Ogdie et al.). Second, they performed an unweighted rank-based genome search meta-analysis (GSMA) of the two genome scans. |
| Basic Result |
There is evidence for linkage within each individual study and significant evidence for a risk gene on 5p13 based on the pooled data. While the UCLA data contribute heavily to the joint linkage peak at 5p13, GSMA yields a pointwise significant PAR at that region, indicating a nominally significant overlap of rank-ordered bins that is independent of the varying signal strengths in the two samples. GSMA defined six bins with PAR <0.05 (~5p13, 11q25, 13q34,15q26, 16q23, and 20q13), which is in fact the exact expectation under the null distribution of two unrelated linkage scans, suggesting that there are few common effect loci between the two studies. In aggregate, both the pooled linkage analysis and the GSMA indicate that there is a lack of overlap of linkage peaks with the exception of chromosome 5p13. |
Regions reported by this study: 1
| Region |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
| 5p13 |
MLS=3.67 (empiric P=0.011) |
pointwise significant
pointwise significant
|
Significant
|
Hot Results