ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Meta-analysis Report

Basic Info
Reference Nikolaidis A, 201020019071
Citation Nikolaidis A. and Gray J. R. (2010) "ADHD and the DRD4 exon III 7-repeat polymorphism: an international meta-analysis." Soc Cogn Affect Neurosci, 5(2-3): 188-93.
Study Type Candidate association study
Summary They sought to elucidate the relationship of ADHD (Attention-Deficit Hyperactivity Disorder) to the DRD4 exon III VNTR 7R allele worldwide using analytic techniques and to relate these findings to the field of cultural neuroscience. To focus on a potential moderating role of race/ethnicity, they excluded over 30 papers that have explored the relationship between the DRD4 7R and ADHD but had unclear or lax racial-ethnic inclusion criteria. The papers in this meta-analysis were only included if a single race made up 95% or more of their sample. They searched for and translated papers not published in English, and found a significant difference in the relationship of ADHD and DRD4 7R in people of European-Caucasian and South American descent vs people of Middle Eastern ancestry. They also examined the moderating effect of differing ADHD diagnoses, subject recruitment, control recruitment and male to female ratio. Finally, they consider the implications of these data for cultural neuroscience.

Detail Info

Genes reported by this study: 1