Meta-analysis Report
Basic Info
| Reference |
Faraone SV, 200111431226
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| Citation |
Faraone S. V., Doyle A. E., Mick E. and Biederman J. (2001) "Meta-analysis of the association between the 7-repeat allele of the dopamine D(4) receptor gene and attention deficit hyperactivity disorder." Am J Psychiatry, 158(7): 1052-7.
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| Study Type |
Candidate association study |
| Summary |
Meta-analysis was applied to case-control and family-based studies of the association between ADHD and DRD4 to assess the joint evidence for the association, the influence of individual studies, and evidence for publication bias. For both the case-control and family-based studies, the authors found 1) support for the association between ADHD and DRD4, 2) no evidence that this association was accounted for by any one study, and 3) no evidence for publication bias. Although the association between ADHD and DRD4 is small, these results suggest that it is real. Further studies are needed to clarify what variant of DRD4 (or some nearby gene) accounts for this association. |
Detail Info
| Samples |
They identified all available studies of the association between ADHD and DRD4 by 1) searching journal abstracts available online through PubMed at the National Library of Medicine, 2) requesting ADHD-DRD4 association data from colleagues presenting such data at national meetings, and 3) querying members of the ADHD molecular genetics e-mail network (funded by NIMH) about the existence of other ADHD-DRD4 data sets that had been published or were being prepared for publication (these latter studies were used with permission of the authors). All studies identified were included. They performed two meta-analyses, one for the case-control studies and one for the family-based studies. |
| Statistic Method |
They used a random effects meta-analysis to analyze the odds ratios by using the method of Carlin. To determine whether the results of the meta-analysis were unduly influenced by any one study, they recomputed the meta-analysis statistic after deleting each study one at a time. They assessed publication bias by using the method of Egger et al. |
| Basic Result |
For both the case-control and family-based studies, the authors found 1) support for the association between ADHD and DRD4, 2) no evidence that this association was accounted for by any one study, and 3) no evidence for publication bias. Although the association between ADHD and DRD4 is small, these results suggest that it is real. Further studies are needed to clarify what variant of DRD4 (or some nearby gene) accounts for this association. |
Genes reported by this study: 1
| Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
| DRD4 |
both the case-control and family-based studies supported for......
both the case-control and family-based studies supported for the association between ADHD and DRD4
More...
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Significant
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Hot Results