ADHDgene Database

SNP Report

Basic Info

Name	rs3758653 dbSNP Ensembl
Location	chr11:636399(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	upstream_gene_variant.
Consequence to Transcript	upstream_gene_variant(ENST00000176183; ENST00000528733)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Lasky-Su J, 2007			Unadjusted FBAT-PC P-value=0.302, Adjusted FBAT-PC P-value=0...... Unadjusted FBAT-PC P-value=0.302, Adjusted FBAT-PC P-value=0.503 under Recessive genetic model; Unadjusted FBAT-PC P-value=0.573, Adjusted FBAT-PC P-value=0.572 under Dominant genetic model. More...	No association with ADHD was found No association with ADHD was found	Non-significant
Oades RD, 2008			P-value=0.008178; FDR P-value=0.08178 for behavioral impulsi...... P-value=0.008178; FDR P-value=0.08178 for behavioral impulsivity More...	attained nominal significance for an association with impuls...... attained nominal significance for an association with impulsive behavioral aggression More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DRD4	dopamine receptor D4	11p15.5	67(49/18/0)

SNPs in LD with rs3758653 (count: 4) View in gBrowse (chr11:605856..636399 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs7932167	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.915[JPT]
rs936470	intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant	0.833[JPT]
rs12360820	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.833[JPT]
rs4623937	intron_variant; nc_transcript_variant; NMD_transcript_variant	0.833[JPT]