ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs2161961 dbSNP Ensembl
Location	Chr18:11774500(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000590228; ENST00000334049; ENST00000585642; ENST00000423027; ENST00000535121; ENST00000269162; ENST00000590972) nc_transcript_variant(ENST00000590972)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Laurin N, 2008(b)	A/G		TDT P-value=0.011, X²=6.485 for all; TDT P-value=...... TDT P-value=0.011, X²=6.485 for all; TDT P-value=0.005, X²=7.796 for one sib; PDT P-value=0.013; PICS-IV P-value=0.003, PICS-IV P-value=0.008 in the quantitative analysis; A allele P-value=0.005, X²=7.926 for maternal transmission More...	demonstrated biased transmission in the categorical analysis...... demonstrated biased transmission in the categorical analysis and significant relationships with dimensional symptoms of inattention and hyperactivity/impulsivity and foudn evidence of strong maternal effect More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
GNAL	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type	18p11.22-p11.21	1(1/0/0)

Genes from other sources (count: 0)

SNPs in LD with rs2161961 (count: 35) View in gBrowse (chr18:11752943..11828828 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 3)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs9962277	intron_variant; nc_transcript_variant	1(0/1/0)	0.952[CHB]; 0.897[CHD]; 0.933[JPT]
rs8098539	intron_variant; nc_transcript_variant	1(1/0/0)	0.866[CHB]; 0.852[CHD]
rs8095592	intron_variant; nc_transcript_variant	1(0/1/0)	0.819[CHB]

LD-proxies (count: 32)

rs_ID	Functional Annotation	r²[population]
rs12962767	intron_variant; nc_transcript_variant	1.0[CEU]; 0.901[CHB]; 0.868[JPT]
rs1895689	intron_variant; nc_transcript_variant; upstream_gene_variant	0.819[CHB]
rs1614379	intron_variant; nc_transcript_variant	0.933[CEU]
rs12327266	intron_variant; nc_transcript_variant	0.866[CHB]; 0.805[CHD]
rs1647558	intron_variant; nc_transcript_variant	0.933[CEU]; 0.82[CHD]; 0.813[MEX]
rs9962908	intron_variant; nc_transcript_variant	0.82[CEU]
rs8086766	intron_variant; nc_transcript_variant	0.816[CHB]
rs9303748	intron_variant; nc_transcript_variant	0.952[CHB]; 0.897[CHD]; 0.933[JPT]
rs1364632	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.906[CHB]; 0.897[CHD]; 0.925[GIH]; 0.801[JPT]; 0.813[MEX]; 0.91[TSI]
rs8087789	intron_variant; nc_transcript_variant	0.82[CEU]
rs1786568	intron_variant; nc_transcript_variant	0.817[CHB]
rs9948889	intron_variant; nc_transcript_variant	0.816[CHB]; 0.825[CHD]
rs1477481	intron_variant; nc_transcript_variant	0.952[CHB]; 0.897[CHD]; 0.933[JPT]
rs1786567	intron_variant; nc_transcript_variant	0.933[CEU]
rs7240684	intron_variant; nc_transcript_variant; upstream_gene_variant	0.862[CHB]; 0.868[JPT]
rs9303749	intron_variant; nc_transcript_variant	1.0[CEU]; 0.906[CHB]; 0.897[CHD]; 0.925[GIH]; 0.91[TSI]
rs1647556	intron_variant; nc_transcript_variant	0.933[CEU]
rs9966733	intron_variant; nc_transcript_variant	0.811[CEU]
rs8090320	intron_variant; nc_transcript_variant	0.819[CEU]
rs11080534	intron_variant; nc_transcript_variant	0.952[CHB]; 0.922[CHD]; 0.933[JPT]
rs12965256	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.906[CHB]; 0.897[CHD]; 0.925[GIH]; 0.868[JPT]; 0.909[TSI]
rs10048315	intron_variant; nc_transcript_variant	0.862[CHB]; 0.868[JPT]
rs16976671	intron_variant; nc_transcript_variant	1.0[CEU]; 0.904[CHB]; 0.93[JPT]
rs1786566	intron_variant; nc_transcript_variant	0.933[CEU]; 0.821[CHD]
rs12965108	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.906[CHB]; 0.897[CHD]; 0.925[GIH]; 0.868[JPT]; 0.813[MEX]; 0.91[TSI]
rs10048316	intron_variant; nc_transcript_variant	0.857[CHB]; 0.868[JPT]
rs9303746	intron_variant; nc_transcript_variant	0.866[CHB]; 0.852[CHD]
rs10468681	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.922[CHD]; 0.949[GIH]; 0.933[JPT]; 0.813[MEX]; 0.91[TSI]
rs7240632	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.895[CHB]; 0.827[JPT]
rs9962623	intron_variant; nc_transcript_variant	0.82[CEU]
rs8094039	intron_variant; nc_transcript_variant	0.825[CHD]
rs1786564	intron_variant; nc_transcript_variant	0.933[CEU]