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KEGG Pathway Report
Basic Info
| ID | hsa04966 |
|---|---|
| Name | Collecting duct acid secretion |
| Description | One of the important roles of the collecting duct segment of the kidney nephron is acid secretion. As daily food intake loads acid into the body, urinary acid excretion is essential, and urine pH can drop as low as 4.5. The alpha-intercalated cell of collecting duct is the main responsible for hydrogen secretion into the urine. The carbon dioxide, which is generated in the cells and enters from the blood, is changed to carbonic acid. This carbonic acid is divided into hydrogen ion and bicarbonate ion. Intracellular CA II catalyses the formation of these ions. The hydrogen ion is secreted into the lumen by the luminal H(+)-ATPase. The bicarbonate ion is transported to the blood side by the anion exchanger type 1. Hydrogen ion in the lumen is trapped by urinary buffers. These include ammonium and phosphate. |
| No. of Genes in ADHDgene | 7 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 7)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 7)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 2p25.1 | Mapped by significant region |
| CA2 | carbonic anhydrase II | 8q22 | Mapped by CNV |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 9q33.1 | Mapped by significant region |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 7q32.1 | Mapped by LD-proxy |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 11q13.2 | Mapped by significant region |
| ATP6V0A2 | ATPase, H+ transporting, lysosomal V0 subunit a2 | 12q24.31 | Mapped by CNV |
| ATP6V0D2 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | 8q21.3 | Mapped by CNV |