ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name DRD4_promoter_-616C/G
Type point mutation
Location promoter
Related Gene DRD4
No. of Study 5 (significant: 1; non-significant 4; trend: 0)

Variant related studies (count: 5)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Lowe N, 2004 (a) C/G TDT P-value=0.008, OR=1.63, 95% CI=1.16-2.38 TDT P-value=0.008, OR=1.63, 95% CI=1.16-2.38 significant over transmission significant over transmission Significant
Barr CL, 2001(d) C/G allelic P-value=0.154, X2=2.036 allelic P-value=0.154, X2=2.036 there was a trend for the transmission of allele C but this ...... there was a trend for the transmission of allele C but this was also not significant More... Non-significant
Mill J, 2003 C/G TRANSMIT P-value>0.05 TRANSMIT P-value>0.05 no evidence of biased transmission to ADHD probands was foun...... no evidence of biased transmission to ADHD probands was found More... Non-significant
Kirley A, 2004 allelic TDT P-value=0.21, X2=1.86 in combined sub...... allelic TDT P-value=0.21, X2=1.86 in combined subtype More... there was no association between this variant and DSM-IV com...... there was no association between this variant and DSM-IV combined type ADHD More... Non-significant
Kereszturi E, 2007 C/G No association was found between ADHD and this SNP No association was found between ADHD and this SNP Non-significant