ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name COMT_Val158Met
Type point mutation
Related Gene COMT
No. of Study 1 (significant: 1; non-significant 0; trend: 0)

Variant related studies (count: 1)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Martinez-Levy, G. A.,2013 Val158Met HWE:F =-0.01;P-value=0.83; Met/Met genotypic P-value =0.008,...... HWE:F =-0.01;P-value=0.83; Met/Met genotypic P-value =0.008,OR= 2.1,CI 95%=1.2-3.4;when an interaction with sex was tested, an association between the COMT Met/Met genotype ¡Á males was observed OR=2.3, CI 95%=1.1-4.6, P-value =0.02 and a protective effect of the COMT Val + genotype¡ÁFemales was also detected OR=0.5, CI 95%=0.2-0.4, P-value =0.006. More... A logistic regression analysis showed that individuals with ...... A logistic regression analysis showed that individuals with the COMT Met/Met genotype were more likely to belong to the hyperactive/impulsive-combined ADHD subgroup More... Significant