ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ZEB2
Previous Symbol	ZFHX1B
Symbol Alias	KIAA0569, SIP-1, SIP1
Approved Name	zinc finger E-box binding homeobox 2
Previous Name	"zinc finger homeobox 1b"
Name Alias	"SMAD interacting protein 1"
Location	2q22.3
Position	chr2:145141648-145282147, -1
External Links	HGNC: 14881 Entrez Gene: 9839 Ensembl: ENSG00000169554 UCSC: uc002tvu.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9322993	chr14:39605542(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001843	neural tube closure	biological process	IEA	12
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0021846	cell proliferation in forebrain	biological process	IEA	3
GO:0030177	positive regulation of Wnt receptor signaling pathway	biological process	IEA	3
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0005730	nucleolus	cellular component	IDA	271
GO:0021766	hippocampus development	biological process	IEA	8
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0043507	positive regulation of JUN kinase activity	biological process	IEA	8
GO:0001756	somitogenesis	biological process	IEA	8
GO:0001755	neural crest cell migration	biological process	IEA	8
GO:0019208	phosphatase regulator activity	molecular function	NAS[11477103]	1
GO:0005634	nucleus	cellular component	IDA	877
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0007399	nervous system development	biological process	NAS[11279515]	60
GO:0046332	SMAD binding	molecular function	NAS	9

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ZEB2 (count: 41)

Gene Symbol	Pathway Count	Pathway List
LHX2	6	neural tube closure; zinc ion binding; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
GATAD2A	6	zinc ion binding; sequence-specific DNA binding; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF367	6	zinc ion binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF174	6	zinc ion binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MTA3	6	zinc ion binding; sequence-specific DNA binding; cytoplasm; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity;
PRDM1	6	zinc ion binding; sequence-specific DNA binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
IKZF1	6	zinc ion binding; sequence-specific DNA binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF263	6	zinc ion binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
POU2F3	6	sequence-specific DNA binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
HOXB1	6	sequence-specific DNA binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
TSHZ2	5	zinc ion binding; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF397	5	zinc ion binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
TRIM22	5	zinc ion binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ISL1	5	zinc ion binding; cytoplasm; neural crest cell migration; nucleus; sequence-specific DNA binding transcription factor activity;
LHX1	5	zinc ion binding; sequence-specific DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; nervous system development;
DPF2	5	zinc ion binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus;
MYT1L	5	zinc ion binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; nervous system development;
LHX6	5	zinc ion binding; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF396	5	zinc ion binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF24	5	zinc ion binding; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
NR4A2	5	zinc ion binding; sequence-specific DNA binding; cytoplasm; transcription, DNA-dependent; nucleus;
ZSCAN10	5	zinc ion binding; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
FOXP1	5	zinc ion binding; sequence-specific DNA binding; cytoplasm; nucleolus; nucleus;
HINFP	5	zinc ion binding; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
PGR	5	zinc ion binding; sequence-specific DNA binding; cytoplasm; nucleolus; nucleus;
MTA2	5	zinc ion binding; sequence-specific DNA binding; nucleolus; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF77	5	zinc ion binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus;
LMX1B	5	zinc ion binding; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
PHF1	5	zinc ion binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
FOXD4	5	sequence-specific DNA binding; nucleolus; neural crest cell migration; nucleus; sequence-specific DNA binding transcription factor activity;
BSX	5	sequence-specific DNA binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA9	5	sequence-specific DNA binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA3	5	sequence-specific DNA binding; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA2	5	sequence-specific DNA binding; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
HES1	5	sequence-specific DNA binding; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; nervous system development;
HOXA11	5	sequence-specific DNA binding; cytoplasm; nucleolus; transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
MEN1	5	sequence-specific DNA binding; cytoplasm; nucleolus; transcription, DNA-dependent; nucleus;
TBX1	5	sequence-specific DNA binding; transcription, DNA-dependent; neural crest cell migration; nucleus; sequence-specific DNA binding transcription factor activity;
IRX3	5	sequence-specific DNA binding; cytoplasm; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
TCF25	5	cytoplasm; nucleolus; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
SOX8	5	cytoplasm; transcription, DNA-dependent; neural crest cell migration; nucleus; sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with ZEB2 (count: 0)

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Region: chr2:145141648..145282147 View in gBrowse