ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TNNI3K
Symbol Alias	CARK
Approved Name	TNNI3 interacting kinase
Location	1p31.1
Position	chr1:74663947-75010112, 1
External Links	HGNC: 19661 Entrez Gene: 51086 Ensembl: ENSG00000116783
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Albayrak O., 2013	No significant association was reported in this study.	Non-significant

Gene related SNPs (count: 41)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1514175	chr1:74991644(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 40)

rs_ID	Location	Functional Annotation
rs7526762	chr1:74993318(Fwd)	intron_variant
rs1514173	chr1:74995110(Fwd)	intron_variant
rs7551507	chr1:74995225(Fwd)	intron_variant
rs12042908	chr1:74997762(Fwd)	intron_variant
rs6703637	chr1:74997795(Fwd)	intron_variant
rs6698622	chr1:74997956(Fwd)	intron_variant
rs2344508	chr1:74999713(Fwd)	intron_variant
rs12142020	chr1:75000011(Fwd)	intron_variant
rs3845344	chr1:75001480(Fwd)	intron_variant; upstream_gene_variant
rs3894212	chr1:75001683(Fwd)	intron_variant; upstream_gene_variant
rs12566985	chr1:75002193(Fwd)	intron_variant; upstream_gene_variant
rs3845345	chr1:75002667(Fwd)	intron_variant; upstream_gene_variant
rs12041852	chr1:75003500(Fwd)	intron_variant; upstream_gene_variant
rs12041912	chr1:75003710(Fwd)	intron_variant; upstream_gene_variant
rs3845347	chr1:75004048(Fwd)	intron_variant; upstream_gene_variant
rs6604872	chr1:75004611(Fwd)	intron_variant; upstream_gene_variant
rs953567	chr1:74977425(Fwd)	intron_variant
rs6690871	chr1:74977277(Fwd)	intron_variant
rs12036473	chr1:74979975(Fwd)	intron_variant; upstream_gene_variant
rs1040070	chr1:74977870(Fwd)	intron_variant
rs1514177	chr1:74991402(Fwd)	intron_variant
rs10493544	chr1:74983835(Fwd)	intron_variant
rs6604867	chr1:74992278(Fwd)	intron_variant
rs1514176	chr1:74991596(Fwd)	intron_variant
rs1514174	chr1:74993063(Fwd)	intron_variant
rs6604866	chr1:74992546(Fwd)	intron_variant
rs3843262	chr1:75013054(Fwd)	downstream_gene_variant
rs10789396	chr1:75014362(Fwd)	downstream_gene_variant
rs6604871	chr1:75008008(Fwd)	intron_variant; nc_transcript_variant
rs11210478	chr1:75008411(Fwd)	intron_variant; nc_transcript_variant
rs6669189	chr1:75011358(Fwd)	downstream_gene_variant
rs10218727	chr1:75012637(Fwd)	downstream_gene_variant
rs6656785	chr1:75005776(Fwd)	intron_variant; upstream_gene_variant
rs3895907	chr1:75006027(Fwd)	intron_variant; nc_transcript_variant
rs7514705	chr1:75006720(Fwd)	intron_variant; nc_transcript_variant
rs3765680	chr1:75007008(Fwd)	intron_variant; nc_transcript_variant
rs10890130	chr1:75004875(Fwd)	intron_variant; upstream_gene_variant
rs7520945	chr1:75004943(Fwd)	intron_variant; upstream_gene_variant
rs7553348	chr1:75005067(Fwd)	intron_variant; upstream_gene_variant
rs7553158	chr1:75005238(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008022	protein C-terminus binding	molecular function	IPI[18205602]	42
GO:0004672	protein kinase activity	molecular function	IDA[12721663]	31
GO:0005634	nucleus	cellular component	IDA[12721663]	877
GO:0006468	protein phosphorylation	biological process	IDA[12721663]	58
GO:0004674	protein serine/threonine kinase activity	molecular function	IEA	65
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0031013	troponin I binding	molecular function	IPI[12721663]	1
GO:0005737	cytoplasm	cellular component	IDA[12721663]	781
GO:0005524	ATP binding	molecular function	IEA	265
GO:0005515	protein binding	molecular function	IPI[12721663]	1015

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TNNI3K (count: 36)

Gene Symbol	Pathway Count	Pathway List
PRKAA1	7	protein C-terminus binding; protein kinase activity; nucleus; protein phosphorylation; metal ion binding; ATP binding; protein binding;
SMG1	7	protein kinase activity; nucleus; protein serine/threonine kinase activity; metal ion binding; cytoplasm; ATP binding; protein binding;
AURKC	6	protein kinase activity; nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding;
PAK1	6	protein kinase activity; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
TGFBR1	6	protein kinase activity; protein phosphorylation; protein serine/threonine kinase activity; metal ion binding; ATP binding; protein binding;
MAP2K5	6	protein kinase activity; nucleus; protein serine/threonine kinase activity; metal ion binding; ATP binding; protein binding;
PLK1	6	protein kinase activity; nucleus; protein phosphorylation; protein serine/threonine kinase activity; ATP binding; protein binding;
CSNK1E	6	protein kinase activity; nucleus; protein phosphorylation; protein serine/threonine kinase activity; ATP binding; protein binding;
MAP3K11	6	protein kinase activity; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
GSK3B	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
LATS2	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; metal ion binding; ATP binding; protein binding;
NEK6	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
SIK2	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
STK36	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
PRKD1	6	nucleus; protein serine/threonine kinase activity; metal ion binding; cytoplasm; ATP binding; protein binding;
STK11	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
ROCK2	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; metal ion binding; ATP binding; protein binding;
RPS6KA4	6	nucleus; protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
ERBB2	5	protein C-terminus binding; nucleus; protein phosphorylation; ATP binding; protein binding;
XRCC5	5	protein C-terminus binding; nucleus; cytoplasm; ATP binding; protein binding;
UBE2I	5	protein C-terminus binding; nucleus; cytoplasm; ATP binding; protein binding;
PICK1	5	protein C-terminus binding; protein phosphorylation; metal ion binding; cytoplasm; protein binding;
PKMYT1	5	protein kinase activity; protein serine/threonine kinase activity; metal ion binding; ATP binding; protein binding;
PIK3CG	5	protein kinase activity; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
NUBP2	5	nucleus; metal ion binding; cytoplasm; ATP binding; protein binding;
MARK2	5	nucleus; protein phosphorylation; protein serine/threonine kinase activity; ATP binding; protein binding;
DNAJA3	5	nucleus; metal ion binding; cytoplasm; ATP binding; protein binding;
NEK4	5	nucleus; protein phosphorylation; protein serine/threonine kinase activity; metal ion binding; ATP binding;
FRK	5	nucleus; protein phosphorylation; cytoplasm; ATP binding; protein binding;
MAPK1	5	nucleus; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
ILK	5	protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
PDPK1	5	protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
CDC42BPG	5	protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
SIK3	5	protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;
BMPR1B	5	protein phosphorylation; protein serine/threonine kinase activity; metal ion binding; ATP binding; protein binding;
TSSK2	5	protein phosphorylation; protein serine/threonine kinase activity; cytoplasm; ATP binding; protein binding;

Genes shared at least 2 KEGG pathways with TNNI3K (count: 0)

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Region: chr1:74663947..75010112 View in gBrowse