ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TFAP2B
Symbol Alias	AP2-B
Approved Name	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Previous Name	"transcription factor AP-2 beta (activating enhancer-binding protein 2 beta)"
Location	6p12
Position	chr6:50786436-50815326, 1
External Links	HGNC: 11743 Entrez Gene: 7021 Ensembl: ENSG00000008196 UCSC: uc003pag.3
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Albayrak O., 2013	The BMI SNP risk alleles of this gene were associated with the quantitative trait inattention with uncorrected P-values below 0.05.	Significant

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs987237	chr6:50803050(Fwd)	intron_variant	1(1/0/0)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs2206277	chr6:50798526(Fwd)	downstream_gene_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 55)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 55)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0050796	regulation of insulin secretion	biological process	IMP[19325541]	25
GO:0097070	ductus arteriosus closure	biological process	ISS	1
GO:0042593	glucose homeostasis	biological process	ISS	21
GO:0035909	aorta morphogenesis	biological process	ISS	2
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA	77
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity	molecular function	ISS	2
GO:0045595	regulation of cell differentiation	biological process	IDA	7
GO:0005515	protein binding	molecular function	IPI[19115315]	1015
GO:0045444	fat cell differentiation	biological process	IEP[16373396]	12
GO:0035810	positive regulation of urine volume	biological process	ISS	4
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	molecular function	IDA[7555706]	6
GO:0003677	DNA binding	molecular function	TAS[12072434]	257
GO:0008284	positive regulation of cell proliferation	biological process	IDA[17525748]	75
GO:0072017	distal tubule development	biological process	ISS	1
GO:0055062	phosphate ion homeostasis	biological process	ISS	1
GO:0001105	RNA polymerase II transcription coactivator activity	molecular function	ISS	3
GO:0003714	transcription corepressor activity	molecular function	IDA[7559606]	33
GO:0035137	hindlimb morphogenesis	biological process	ISS	3
GO:0003713	transcription coactivator activity	molecular function	IDA[7555706]	58
GO:0055075	potassium ion homeostasis	biological process	ISS	1
GO:0055078	sodium ion homeostasis	biological process	ISS	1
GO:0043588	skin development	biological process	IEA	8
GO:0006006	glucose metabolic process	biological process	IMP[19325541]	20
GO:0048485	sympathetic nervous system development	biological process	ISS	5
GO:0097275	cellular ammonia homeostasis	biological process	ISS	1
GO:0001158	enhancer sequence-specific DNA binding	molecular function	IDA[16373396]	3
GO:0046983	protein dimerization activity	molecular function	IDA[12072434]	28
GO:0010960	magnesium ion homeostasis	biological process	ISS	2
GO:0072044	collecting duct development	biological process	ISS	1
GO:0035136	forelimb morphogenesis	biological process	ISS	5
GO:0072210	metanephric nephron development	biological process	IEA	1
GO:0097276	cellular creatinine homeostasis	biological process	ISS	1
GO:0030510	regulation of BMP signaling pathway	biological process	ISS	3
GO:0001822	kidney development	biological process	ISS	17
GO:0003091	renal water homeostasis	biological process	ISS	1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[12169688]	141
GO:0005634	nucleus	cellular component	IC[12169688]; IDA	877
GO:0097277	cellular urea homeostasis	biological process	ISS	1
GO:0046982	protein heterodimerization activity	molecular function	IPI[11505339]	73
GO:0006355	regulation of transcription, DNA-dependent	biological process	IDA[12169688]	182
GO:0001106	RNA polymerase II transcription corepressor activity	molecular function	ISS	4
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[7559606]	90
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[12169688]	148
GO:0042803	protein homodimerization activity	molecular function	IPI[11505339]	128
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	biological process	ISS	12
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[11505339]; IMP[16373396]	89
GO:0043066	negative regulation of apoptotic process	biological process	IDA[17525748]; ISS	85
GO:0043525	positive regulation of neuron apoptotic process	biological process	IDA	10
GO:0008285	negative regulation of cell proliferation	biological process	IDA	65
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process	molecular function	ISS	7
GO:0055074	calcium ion homeostasis	biological process	ISS	2
GO:0010842	retina layer formation	biological process	IEP	3
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	molecular function	IEA	8
GO:0043565	sequence-specific DNA binding	molecular function	IDA[12169688]	80
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	molecular function	IDA[7555706]	7

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TFAP2B (count: 125)

Gene Symbol	Pathway Count	Pathway List
HNF1B	12	protein binding; DNA binding; kidney development; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein heterodimerization activity; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein homodimerization activity; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; sequence-specific DNA binding;
TFAP4	11	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; transcription coactivator activity; nucleus; protein heterodimerization activity; protein homodimerization activity; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; negative regulation of cell proliferation; sequence-specific DNA binding;
TBX1	10	aorta morphogenesis; DNA binding; positive regulation of cell proliferation; protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein homodimerization activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
KLF4	10	negative regulation of transcription, DNA-dependent; regulation of cell differentiation; fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription, DNA-dependent; negative regulation of cell proliferation; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription;
HES1	10	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein homodimerization activity; sequence-specific DNA binding;
RELA	10	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; sequence-specific DNA binding;
GATA6	9	negative regulation of transcription, DNA-dependent; protein binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of apoptotic process; RNA polymerase II core promoter sequence-specific DNA binding;
FOXE1	9	negative regulation of transcription, DNA-dependent; DNA binding; sympathetic nervous system development; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
SOX8	9	negative regulation of transcription, DNA-dependent; fat cell differentiation; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; RNA polymerase II core promoter sequence-specific DNA binding;
HEY2	9	negative regulation of transcription, DNA-dependent; RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity; protein binding; protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
ETS1	9	protein binding; DNA binding; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of cell proliferation; sequence-specific DNA binding;
VEGFA	9	protein binding; positive regulation of cell proliferation; kidney development; positive regulation of transcription from RNA polymerase II promoter; protein heterodimerization activity; negative regulation of transcription from RNA polymerase II promoter; protein homodimerization activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process;
MED1	9	protein binding; fat cell differentiation; sequence-specific DNA binding RNA polymerase II transcription factor activity; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process;
HINFP	8	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; transcription coactivator activity; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
MYB	8	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
HMGA1	8	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of cell proliferation;
RBPJ	8	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription;
ZBTB16	8	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; forelimb morphogenesis; nucleus; protein homodimerization activity; positive regulation of transcription, DNA-dependent; negative regulation of cell proliferation;
LHX1	8	negative regulation of transcription, DNA-dependent; transcription corepressor activity; kidney development; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; retina layer formation; sequence-specific DNA binding;
CREBBP	8	protein binding; RNA polymerase II transcription coactivator activity; transcription coactivator activity; nucleus; regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
SREBF1	8	protein binding; DNA binding; protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXC2	8	positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding;
INS	7	regulation of insulin secretion; glucose homeostasis; protein binding; positive regulation of cell proliferation; glucose metabolic process; regulation of transcription, DNA-dependent; negative regulation of apoptotic process;
PRKAA1	7	glucose homeostasis; protein binding; positive regulation of cell proliferation; glucose metabolic process; nucleus; regulation of transcription, DNA-dependent; negative regulation of apoptotic process;
FOXG1	7	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding;
KDM1A	7	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of apoptotic process;
KAT5	7	negative regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
CIITA	7	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
SNW1	7	negative regulation of transcription, DNA-dependent; protein binding; transcription corepressor activity; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MEN1	7	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; sequence-specific DNA binding;
IRF7	7	protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; RNA polymerase II core promoter sequence-specific DNA binding;
CREB5	7	protein binding; fat cell differentiation; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding;
MEIS2	7	protein binding; transcription corepressor activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
NRIP1	7	protein binding; transcription corepressor activity; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
YAP1	7	protein binding; positive regulation of cell proliferation; transcription corepressor activity; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of apoptotic process;
DRAP1	7	DNA binding; transcription corepressor activity; nucleus; protein heterodimerization activity; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
IKZF1	7	DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein heterodimerization activity; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
ISL1	7	positive regulation of cell proliferation; RNA polymerase II transcription coactivator activity; enhancer sequence-specific DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
ADRA2A	6	regulation of insulin secretion; glucose homeostasis; protein binding; positive regulation of cell proliferation; protein heterodimerization activity; protein homodimerization activity;
GLIS2	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription;
RREB1	6	negative regulation of transcription, DNA-dependent; DNA binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
ZNF24	6	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HOXA7	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
SPI1	6	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
FOXP2	6	negative regulation of transcription, DNA-dependent; DNA binding; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity; protein homodimerization activity; sequence-specific DNA binding;
CREBZF	6	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
STRN3	6	negative regulation of transcription, DNA-dependent; protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
NIPBL	6	negative regulation of transcription, DNA-dependent; protein binding; fat cell differentiation; forelimb morphogenesis; nucleus; negative regulation of transcription from RNA polymerase II promoter;
ID2	6	negative regulation of transcription, DNA-dependent; protein binding; protein dimerization activity; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent;
GSK3B	6	negative regulation of transcription, DNA-dependent; protein binding; fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of apoptotic process;
FOXP1	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein heterodimerization activity; protein homodimerization activity; sequence-specific DNA binding;
BIRC2	6	regulation of cell differentiation; protein binding; transcription coactivator activity; nucleus; regulation of transcription, DNA-dependent; negative regulation of apoptotic process;
HOXA5	6	protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
KMT2A	6	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein homodimerization activity; positive regulation of transcription, DNA-dependent;
MTA2	6	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
POU2F3	6	protein binding; protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TNFAIP3	6	protein binding; DNA binding; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; cysteine-type endopeptidase inhibitor activity involved in apoptotic process;
MAP2K5	6	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process;
DNAJA3	6	protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; negative regulation of cell proliferation;
SNCA	6	protein binding; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; calcium ion homeostasis;
E4F1	6	protein binding; DNA binding; transcription corepressor activity; transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
NR5A1	6	protein binding; DNA binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding;
CRYAB	6	protein binding; glucose metabolic process; nucleus; protein homodimerization activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process;
NPAT	6	protein binding; transcription corepressor activity; transcription coactivator activity; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
ADORA2A	6	protein binding; positive regulation of urine volume; protein heterodimerization activity; regulation of transcription, DNA-dependent; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cell proliferation;
APC	6	protein binding; skin development; kidney development; nucleus; negative regulation of apoptotic process; negative regulation of cell proliferation;
TGFBR1	6	protein binding; positive regulation of cell proliferation; kidney development; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process;
HOXB1	6	DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXF1	6	DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
HOXA13	6	DNA binding; regulation of BMP signaling pathway; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXL1	6	DNA binding; forelimb morphogenesis; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
NFIL3	6	DNA binding; transcription corepressor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; RNA polymerase II core promoter sequence-specific DNA binding;
IL6	6	positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; negative regulation of cell proliferation;
BCL11A	6	transcription corepressor activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein heterodimerization activity; regulation of transcription, DNA-dependent; protein homodimerization activity;
FOXD4	6	sympathetic nervous system development; positive regulation of transcription from RNA polymerase II promoter; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TCF21	6	protein dimerization activity; kidney development; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription;
RFX6	5	regulation of insulin secretion; glucose homeostasis; protein binding; nucleus; positive regulation of transcription, DNA-dependent;
GATAD2A	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
DAB2	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process;
ZNF263	5	negative regulation of transcription, DNA-dependent; DNA binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
ZNF423	5	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; nucleus; positive regulation of transcription, DNA-dependent;
ZNF174	5	negative regulation of transcription, DNA-dependent; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; protein homodimerization activity;
DAXX	5	negative regulation of transcription, DNA-dependent; protein binding; nucleus; regulation of transcription, DNA-dependent; protein homodimerization activity;
XRCC5	5	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; nucleus; negative regulation of apoptotic process;
ATXN1	5	negative regulation of transcription, DNA-dependent; protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus;
ELK3	5	negative regulation of transcription, DNA-dependent; protein binding; transcription corepressor activity; nucleus; sequence-specific DNA binding transcription factor activity;
THRAP3	5	protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent;
LMX1B	5	protein binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
AATF	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of apoptotic process;
NR4A2	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein heterodimerization activity; sequence-specific DNA binding;
ESRRA	5	protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding;
MAPK1	5	protein binding; DNA binding; positive regulation of cell proliferation; nucleus; positive regulation of transcription, DNA-dependent;
MKL2	5	protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
SMARCB1	5	protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of cell proliferation;
TRIM32	5	protein binding; fat cell differentiation; transcription coactivator activity; nucleus; negative regulation of apoptotic process;
TSC2	5	protein binding; nucleus; protein heterodimerization activity; protein homodimerization activity; negative regulation of cell proliferation;
TCF25	5	protein binding; DNA binding; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity;
KLF13	5	protein binding; DNA binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of cell proliferation;
PKD1	5	protein binding; skin development; kidney development; positive regulation of transcription from RNA polymerase II promoter; nucleus;
TAF13	5	protein binding; DNA binding; nucleus; protein heterodimerization activity; sequence-specific DNA binding transcription factor activity;
HOXA1	5	protein binding; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
BNIP3	5	protein binding; nucleus; protein heterodimerization activity; protein homodimerization activity; negative regulation of apoptotic process;
ZNF205	5	protein binding; DNA binding; nucleus; regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter;
CBL	5	protein binding; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; negative regulation of apoptotic process;
ATF6	5	protein binding; transcription coactivator activity; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
BARD1	5	protein binding; nucleus; protein heterodimerization activity; protein homodimerization activity; negative regulation of apoptotic process;
RNF20	5	protein binding; transcription coactivator activity; nucleus; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
FOSL1	5	protein binding; positive regulation of cell proliferation; nucleus; sequence-specific DNA binding transcription factor activity; negative regulation of cell proliferation;
ATM	5	protein binding; DNA binding; protein dimerization activity; negative regulation of apoptotic process; positive regulation of neuron apoptotic process;
NCOA6	5	protein binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent;
NCOR2	5	protein binding; DNA binding; transcription corepressor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter;
KLF11	5	sequence-specific DNA binding RNA polymerase II transcription factor activity; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; negative regulation of cell proliferation;
ETV5	5	DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
TAF4B	5	DNA binding; nucleus; protein heterodimerization activity; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
EBF1	5	DNA binding; protein dimerization activity; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent;
FEV	5	transcription corepressor activity; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
HSF2	5	transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein homodimerization activity;
SUPT3H	5	transcription coactivator activity; nucleus; protein heterodimerization activity; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent;
CLOCK	5	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; nucleus; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
PRDX5	5	protein dimerization activity; nucleus; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of apoptotic process; cysteine-type endopeptidase inhibitor activity involved in apoptotic process;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
LHX2	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding;
FGF10	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of transcription, DNA-dependent; negative regulation of apoptotic process; negative regulation of cell proliferation;
HOXA2	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TFEB	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein heterodimerization activity; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with TFAP2B (count: 0)

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Region: chr6:50786436..50815326 View in gBrowse