ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STUB1
Symbol Alias	UBOX1, CHIP, SDCCAG7, HSPABP2, NY-CO-7
Approved Name	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
Previous Name	"STIP1 homology and U-box containing protein 1"
Location	16p13.3
Position	chr16:730224-732870, 1
External Links	HGNC: 11427 Entrez Gene: 10273 Ensembl: ENSG00000103266 UCSC: uc002cit.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13	chr16:0-16800000	3 (2/1/0)
16p13.3	chr16:0-7900000	1 (1/0/0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000209	protein polyubiquitination	biological process	IDA[15781469]; IMP[19713937]	26
GO:0031398	positive regulation of protein ubiquitination	biological process	IDA[16831871]	11
GO:0031371	ubiquitin conjugating enzyme complex	cellular component	TAS[16307917]	1
GO:0019900	kinase binding	molecular function	IPI[17512523]	8
GO:0000151	ubiquitin ligase complex	cellular component	IDA[16307917]	17
GO:0005829	cytosol	cellular component	TAS	485
GO:0006515	misfolded or incompletely synthesized protein catabolic process	biological process	IDA[16831871]	1
GO:0031943	regulation of glucocorticoid metabolic process	biological process	IDA[11146632]	2
GO:0071218	cellular response to misfolded protein	biological process	IDA[16831871]	1
GO:0042803	protein homodimerization activity	molecular function	ISS	128
GO:0090035	positive regulation of chaperone-mediated protein complex assembly	biological process	IDA[16831871]	1
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA[15466472]; IMP[19713937]; TAS	60
GO:0051787	misfolded protein binding	molecular function	IDA[16831871]	2
GO:0005515	protein binding	molecular function	IPI	1015
GO:0019899	enzyme binding	molecular function	IPI[16280320]	54
GO:0006281	DNA repair	biological process	IEA	70
GO:0005737	cytoplasm	cellular component	IDA[16831871]	781
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	biological process	IDA[15781469]	17
GO:0070534	protein K63-linked ubiquitination	biological process	IDA[16307917]	4
GO:0031625	ubiquitin protein ligase binding	molecular function	IEA	30
GO:0030544	Hsp70 protein binding	molecular function	IDA[10330192]	7
GO:0030911	TPR domain binding	molecular function	IDA[11146632]	2
GO:0006511	ubiquitin-dependent protein catabolic process	biological process	IMP[19713937]	31
GO:0051865	protein autoubiquitination	biological process	IDA[16307917]	7
GO:0051879	Hsp90 protein binding	molecular function	IDA[11146632]	5
GO:0030674	protein binding, bridging	molecular function	TAS[16307917]	13
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	biological process	TAS	16
GO:0034450	ubiquitin-ubiquitin ligase activity	molecular function	ISS	4
GO:0046332	SMAD binding	molecular function	IDA[15781469]	9
GO:0030579	ubiquitin-dependent SMAD protein catabolic process	biological process	IDA[15781469]	2
GO:0051604	protein maturation	biological process	TAS[16307917]	3
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological process	IDA[11146632]	8
GO:0042405	nuclear inclusion body	cellular component	IDA[16831871]	3
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	TAS	13

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34

Genes shared at least 5 GO terms with STUB1 (count: 32)

Gene Symbol	Pathway Count	Pathway List
AXIN1	10	protein polyubiquitination; positive regulation of protein ubiquitination; cytosol; protein homodimerization activity; protein binding; enzyme binding; cytoplasm; ubiquitin protein ligase binding; SMAD binding; positive regulation of proteasomal ubiquitin-dependent protein catabolic process;
PARK2	10	protein polyubiquitination; kinase binding; cytosol; ubiquitin-protein ligase activity; protein binding; cytoplasm; protein K63-linked ubiquitination; ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process; protein autoubiquitination;
FBXO4	8	protein polyubiquitination; positive regulation of protein ubiquitination; ubiquitin ligase complex; protein homodimerization activity; ubiquitin-protein ligase activity; protein binding; cytoplasm; ubiquitin-dependent protein catabolic process;
RCHY1	8	positive regulation of protein ubiquitination; ubiquitin ligase complex; protein homodimerization activity; ubiquitin-protein ligase activity; protein binding; cytoplasm; protein autoubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process;
PRPF19	7	protein polyubiquitination; ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; DNA repair; cytoplasm; ubiquitin-ubiquitin ligase activity;
ARRB2	7	positive regulation of protein ubiquitination; cytosol; protein binding; cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin protein ligase binding; transforming growth factor beta receptor signaling pathway;
BARD1	7	kinase binding; ubiquitin ligase complex; protein homodimerization activity; ubiquitin-protein ligase activity; protein binding; DNA repair; cytoplasm;
RNF40	7	ubiquitin ligase complex; protein homodimerization activity; ubiquitin-protein ligase activity; protein binding; cytoplasm; ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process;
ERCC8	6	protein polyubiquitination; ubiquitin-protein ligase activity; protein binding; DNA repair; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination;
UBC	6	protein polyubiquitination; cytosol; protein binding; DNA repair; negative regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway;
RNF20	6	protein polyubiquitination; ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; ubiquitin protein ligase binding; ubiquitin-dependent protein catabolic process;
UBB	6	protein polyubiquitination; cytosol; protein binding; DNA repair; negative regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway;
UBE4A	6	protein polyubiquitination; ubiquitin ligase complex; protein binding; cytoplasm; ubiquitin-dependent protein catabolic process; ubiquitin-ubiquitin ligase activity;
HSPA5	6	positive regulation of protein ubiquitination; misfolded protein binding; protein binding; ubiquitin protein ligase binding; protein binding, bridging; negative regulation of transforming growth factor beta receptor signaling pathway;
DAXX	6	cytosol; protein homodimerization activity; protein binding; enzyme binding; cytoplasm; ubiquitin protein ligase binding;
MEN1	6	cytosol; protein binding; DNA repair; cytoplasm; protein binding, bridging; transforming growth factor beta receptor signaling pathway;
NEDD4L	6	cytosol; ubiquitin-protein ligase activity; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway;
UBE2I	6	ubiquitin-protein ligase activity; protein binding; enzyme binding; cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process;
BIRC2	5	protein polyubiquitination; cytosol; ubiquitin-protein ligase activity; protein binding; proteasomal ubiquitin-dependent protein catabolic process;
MGRN1	5	protein polyubiquitination; cytosol; ubiquitin-protein ligase activity; protein binding; cytoplasm;
LRSAM1	5	protein polyubiquitination; ubiquitin-protein ligase activity; protein binding; cytoplasm; protein autoubiquitination;
MALT1	5	positive regulation of protein ubiquitination; cytosol; ubiquitin-protein ligase activity; protein binding; cytoplasm;
TNFAIP3	5	kinase binding; cytosol; ubiquitin-protein ligase activity; protein binding; cytoplasm;
FBXO7	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; protein binding; cytoplasm; ubiquitin-dependent protein catabolic process;
ARRB1	5	cytosol; protein binding; cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; ubiquitin protein ligase binding;
XPO1	5	cytosol; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway;
PPP1CA	5	cytosol; protein binding; cytoplasm; negative regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway;
PDE2A	5	cytosol; protein homodimerization activity; protein binding; cytoplasm; TPR domain binding;
UBE3A	5	cytosol; ubiquitin-protein ligase activity; protein binding; cytoplasm; ubiquitin-dependent protein catabolic process;
TRIM5	5	protein homodimerization activity; ubiquitin-protein ligase activity; protein binding; cytoplasm; protein K63-linked ubiquitination;
TRIM13	5	ubiquitin-protein ligase activity; protein binding; cytoplasm; proteasomal ubiquitin-dependent protein catabolic process; protein autoubiquitination;
HERC2	5	ubiquitin-protein ligase activity; protein binding; DNA repair; cytoplasm; ubiquitin protein ligase binding;

Genes shared at least 2 KEGG pathways with STUB1 (count: 0)

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Region: chr16:730224..732870 View in gBrowse