ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NCAN
Previous Symbol	CSPG3
Approved Name	neurocan
Previous Name	"chondroitin sulfate proteoglycan 3"
Name Alias	"neurocan proteoglycan"
Location	19p12
Position	chr19:19322782-19363042, 1
External Links	HGNC: 2465 Entrez Gene: 1463 Ensembl: ENSG00000130287 UCSC: uc002nlz.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Schimmelmann, B. G.,2013	We found no significant association of childhood ADHD with single BD risk alleles surviving adjustment for multiple testing. Only for the two coding SNPs in NCAN and BRE, we observed a consistent risk allele pattern across both control group comparisons.	Non-significant

Gene related SNPs (count: 8)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1064395	chr19:19361735(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs17216041	chr19:19366643(Fwd)	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant
rs10417330	chr19:19358737(Fwd)	intron_variant; nc_transcript_variant
rs4563151	chr19:19357685(Fwd)	intron_variant; nc_transcript_variant
rs10401714	chr19:19363630(Fwd)	downstream_gene_variant
rs10423874	chr19:19359500(Fwd)	intron_variant; nc_transcript_variant
rs10407933	chr19:19364319(Fwd)	downstream_gene_variant
rs4808933	chr19:19363812(Fwd)	downstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007155	cell adhesion	biological process	IEA	99
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS	9
GO:0030246	carbohydrate binding	molecular function	IEA	31
GO:0030206	chondroitin sulfate biosynthetic process	biological process	TAS	5
GO:0043202	lysosomal lumen	cellular component	TAS	12
GO:0030208	dermatan sulfate biosynthetic process	biological process	TAS	2
GO:0005975	carbohydrate metabolic process	biological process	TAS	59
GO:0005796	Golgi lumen	cellular component	TAS	14
GO:0005576	extracellular region	cellular component	TAS	267
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	23
GO:0005509	calcium ion binding	molecular function	IEA	140
GO:0007411	axon guidance	biological process	TAS	71
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0030207	chondroitin sulfate catabolic process	biological process	TAS	2
GO:0051823	regulation of synapse structural plasticity	biological process	IEA	2
GO:0005540	hyaluronic acid binding	molecular function	IEA	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NCAN (count: 9)

Gene Symbol	Pathway Count	Pathway List
OMD	7	cell adhesion; lysosomal lumen; carbohydrate metabolic process; Golgi lumen; extracellular region; glycosaminoglycan metabolic process; small molecule metabolic process;
CHST9	6	chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; carbohydrate metabolic process; extracellular region; glycosaminoglycan metabolic process; small molecule metabolic process;
GPC6	6	chondroitin sulfate metabolic process; lysosomal lumen; carbohydrate metabolic process; Golgi lumen; glycosaminoglycan metabolic process; small molecule metabolic process;
DSE	6	chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; dermatan sulfate biosynthetic process; carbohydrate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process;
GPC5	6	chondroitin sulfate metabolic process; lysosomal lumen; carbohydrate metabolic process; Golgi lumen; glycosaminoglycan metabolic process; small molecule metabolic process;
ARSB	6	chondroitin sulfate metabolic process; lysosomal lumen; carbohydrate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate catabolic process;
OGN	6	lysosomal lumen; carbohydrate metabolic process; Golgi lumen; extracellular region; glycosaminoglycan metabolic process; small molecule metabolic process;
STAB2	5	cell adhesion; carbohydrate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; hyaluronic acid binding;
CHPF	5	chondroitin sulfate metabolic process; chondroitin sulfate biosynthetic process; carbohydrate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with NCAN (count: 0)

View in gBrowse

Region: chr19:19322782..19363042 View in gBrowse