ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MKL2
Symbol Alias	MRTF-B, FLJ31823
Approved Name	MKL/myocardin-like 2
Location	16p13.12
Position	chr16:14165178-14360630, 1
External Links	HGNC: 29819 Entrez Gene: 57496 Ensembl: ENSG00000186260 UCSC: uc002dcg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13	chr16:0-16800000	3 (2/1/0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001889	liver development	biological process	IEA	16
GO:0048514	blood vessel morphogenesis	biological process	IEA	5
GO:0003007	heart morphogenesis	biological process	IEA	6
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[14565952]	141
GO:0045844	positive regulation of striated muscle tissue development	biological process	IDA[14565952]	1
GO:0007517	muscle organ development	biological process	IEA	17
GO:0003676	nucleic acid binding	molecular function	IEA	46
GO:0006351	transcription, DNA-dependent	biological process	IEA	281
GO:0051145	smooth muscle cell differentiation	biological process	IEA	8
GO:0003779	actin binding	molecular function	IEA	48
GO:0005737	cytoplasm	cellular component	IEA	781
GO:0048738	cardiac muscle tissue development	biological process	IEA	2
GO:0005515	protein binding	molecular function	IPI[14565952]	1015
GO:0005634	nucleus	cellular component	IC[14565952]	877
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	148
GO:0003713	transcription coactivator activity	molecular function	IDA[14565952]	58
GO:0048568	embryonic organ development	biological process	IEA	3
GO:0001701	in utero embryonic development	biological process	IEA	39

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MKL2 (count: 53)

Gene Symbol	Pathway Count	Pathway List
GATA6	7	liver development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; in utero embryonic development;
TBX1	7	blood vessel morphogenesis; heart morphogenesis; positive regulation of transcription from RNA polymerase II promoter; muscle organ development; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
RELA	6	liver development; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
HES1	6	liver development; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
SOX8	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; in utero embryonic development;
HEY2	6	positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
POU2F3	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
KDM1A	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; in utero embryonic development;
HINFP	6	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity; in utero embryonic development;
PHF2	5	liver development; transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
ONECUT2	5	liver development; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MED1	5	liver development; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; transcription coactivator activity;
VEGFA	5	heart morphogenesis; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; in utero embryonic development;
HOXB1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
LPIN1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; transcription coactivator activity;
ETS1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
RBPJ	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; protein binding; nucleus;
YAP1	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; transcription coactivator activity;
FLCN	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; in utero embryonic development;
MEN1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; protein binding; nucleus;
STRN3	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
IKZF1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
UTF1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
HOXA1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
SREBF1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
UBE3A	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; transcription coactivator activity;
SMARCB1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
HSF2	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
BCL11A	5	positive regulation of transcription from RNA polymerase II promoter; nucleic acid binding; transcription, DNA-dependent; cytoplasm; nucleus;
VGLL2	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; transcription coactivator activity;
PKD1	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; in utero embryonic development;
AATF	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
TFAP2B	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
MYB	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; sequence-specific DNA binding transcription factor activity; in utero embryonic development;
NRIP1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; transcription coactivator activity;
HOXA5	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
TFEB	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
NR4A2	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; cytoplasm; protein binding; nucleus;
SMARCD3	5	transcription, DNA-dependent; cytoplasm; protein binding; nucleus; transcription coactivator activity;
LMX1B	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; in utero embryonic development;
GATAD2A	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; in utero embryonic development;
FLII	5	transcription, DNA-dependent; actin binding; cytoplasm; protein binding; nucleus;
MMS19	5	transcription, DNA-dependent; cytoplasm; protein binding; nucleus; transcription coactivator activity;
NPAT	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
ATF6	5	transcription, DNA-dependent; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
HOXA9	5	transcription, DNA-dependent; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
TCF25	5	transcription, DNA-dependent; cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity;
E4F1	5	transcription, DNA-dependent; cytoplasm; protein binding; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
TAF10	5	cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;
CREBBP	5	cytoplasm; protein binding; nucleus; sequence-specific DNA binding transcription factor activity; transcription coactivator activity;

Genes shared at least 2 KEGG pathways with MKL2 (count: 0)

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Region: chr16:14165178..14360630 View in gBrowse