ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAD1L1
Symbol Alias	HsMAD1, TXBP181, MAD1, PIG9, TP53I9
Approved Name	MAD1 mitotic arrest deficient-like 1 (yeast)
Previous Name	"MAD1 (mitotic arrest deficient, yeast, homolog)-like 1"
Location	7p22
Position	chr7:1855429-2272878, -1
External Links	HGNC: 6762 Entrez Gene: 8379 Ensembl: ENSG00000002822 UCSC: uc003slg.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Schimmelmann, B. G.,2013	We found no significant association of childhood ADHD with this gene.	Non-significant

Gene related SNPs (count: 30)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11764590	chr7:2032803(Fwd)	intron_variant	1(0/1/0)
rs10278591	chr7:1921362(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 28)

rs_ID	Location	Functional Annotation
rs9639201	chr7:2087262(Fwd)	intron_variant
rs3996329	chr7:2018870(Fwd)	downstream_gene_variant; intron_variant
rs1403175	chr7:1964357(Fwd)	intron_variant
rs10267593	chr7:1937261(Fwd)	downstream_gene_variant; intron_variant
rs6951956	chr7:1934131(Fwd)	downstream_gene_variant; intron_variant
rs11770148	chr7:1899447(Fwd)	intron_variant; nc_transcript_variant
rs11764337	chr7:1892309(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs10268609	chr7:1962163(Fwd)	intron_variant
rs6461009	chr7:1952139(Fwd)	intron_variant
rs4332037	chr7:1950809(Fwd)	intron_variant
rs6947019	chr7:1950337(Fwd)	intron_variant
rs3823624	chr7:2110346(Fwd)	intron_variant; nc_transcript_variant
rs3996325	chr7:2053747(Fwd)	downstream_gene_variant; intron_variant
rs1533827	chr7:2074290(Fwd)	intron_variant
rs11772627	chr7:2109821(Fwd)	intron_variant; nc_transcript_variant
rs4721098	chr7:1881527(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs11766944	chr7:1888051(Fwd)	3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs1533829	chr7:2082841(Fwd)	intron_variant
rs10276536	chr7:2086960(Fwd)	intron_variant
rs868754	chr7:2033780(Fwd)	intron_variant
rs11762636	chr7:2061111(Fwd)	intron_variant
rs11773627	chr7:2002733(Fwd)	intron_variant
rs12699476	chr7:1968245(Fwd)	intron_variant
rs11765459	chr7:1858475(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs11765458	chr7:1858467(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs7788921	chr7:1915282(Fwd)	intron_variant; upstream_gene_variant
rs4719331	chr7:1914679(Fwd)	intron_variant; upstream_gene_variant
rs11764124	chr7:1891723(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000093	mitotic telophase	biological process	NAS[9546394]	1
GO:0005739	mitochondrion	cellular component	IDA	221
GO:0000075	cell cycle checkpoint	biological process	TAS	21
GO:0007093	mitotic cell cycle checkpoint	biological process	NAS[9546394]	2
GO:0005829	cytosol	cellular component	TAS	485
GO:0000777	condensed chromosome kinetochore	cellular component	IEA	14
GO:0000087	M phase of mitotic cell cycle	biological process	TAS	21
GO:0007094	mitotic cell cycle spindle assembly checkpoint	biological process	TAS	7
GO:0005634	nucleus	cellular component	IDA	877
GO:0000090	mitotic anaphase	biological process	NAS[9546394]	4
GO:0000236	mitotic prometaphase	biological process	TAS	19
GO:0000089	mitotic metaphase	biological process	NAS[9546394]	1
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0005813	centrosome	cellular component	NAS[9546394]	78
GO:0051301	cell division	biological process	IEA	68
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0005819	spindle	cellular component	NAS[9546394]	34
GO:0015629	actin cytoskeleton	cellular component	IDA	30
GO:0005515	protein binding	molecular function	IPI	1015
GO:0005643	nuclear pore	cellular component	IDA[18981471]	11
GO:0000776	kinetochore	cellular component	IDA[18981471]	19

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19

Genes shared at least 5 GO terms with MAD1L1 (count: 55)

Gene Symbol	Pathway Count	Pathway List
SMC1A	10	cell cycle checkpoint; condensed chromosome kinetochore; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; cytoplasm; cell division; mitotic cell cycle; protein binding; kinetochore;
ZW10	10	mitotic cell cycle checkpoint; cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; cell division; mitotic cell cycle; protein binding; kinetochore;
PAFAH1B1	9	cytosol; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; cytoplasm; centrosome; mitotic cell cycle; protein binding; kinetochore;
CENPC	9	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; cytoplasm; cell division; mitotic cell cycle; kinetochore;
MAPRE1	9	cytosol; M phase of mitotic cell cycle; mitotic prometaphase; cytoplasm; centrosome; cell division; mitotic cell cycle; spindle; protein binding;
CLASP1	9	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase; centrosome; cell division; mitotic cell cycle; protein binding; kinetochore;
NDE1	9	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase; centrosome; cell division; mitotic cell cycle; protein binding; kinetochore;
PLK1	9	cytosol; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; centrosome; mitotic cell cycle; spindle; protein binding; kinetochore;
KIF2C	9	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; cell division; mitotic cell cycle; protein binding; kinetochore;
NUMA1	8	cytosol; nucleus; mitotic anaphase; cytoplasm; cell division; mitotic cell cycle; spindle; protein binding;
CLASP2	8	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase; cytoplasm; cell division; mitotic cell cycle; protein binding;
XPO1	8	cytosol; M phase of mitotic cell cycle; mitotic prometaphase; cytoplasm; mitotic cell cycle; protein binding; nuclear pore; kinetochore;
INCENP	8	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle; spindle; protein binding; kinetochore;
ANAPC4	7	cell cycle checkpoint; cytosol; mitotic cell cycle spindle assembly checkpoint; nucleus; mitotic anaphase; cell division; mitotic cell cycle;
APC	7	cytosol; mitotic cell cycle spindle assembly checkpoint; nucleus; cytoplasm; centrosome; protein binding; kinetochore;
CKAP5	7	cytosol; M phase of mitotic cell cycle; mitotic prometaphase; centrosome; cell division; mitotic cell cycle; protein binding;
KIF23	7	cytosol; M phase of mitotic cell cycle; nucleus; centrosome; mitotic cell cycle; spindle; protein binding;
NUP160	7	cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle; protein binding; nuclear pore; kinetochore;
CEP164	7	cytosol; nucleus; cytoplasm; centrosome; cell division; mitotic cell cycle; protein binding;
SMC3	7	M phase of mitotic cell cycle; nucleus; mitotic prometaphase; cytoplasm; cell division; mitotic cell cycle; protein binding;
SNCA	6	mitochondrion; cytosol; nucleus; cytoplasm; actin cytoskeleton; protein binding;
MAPK1	6	mitochondrion; cytosol; nucleus; cytoplasm; spindle; protein binding;
CDC26	6	cell cycle checkpoint; cytosol; mitotic cell cycle spindle assembly checkpoint; cell division; mitotic cell cycle; protein binding;
PSMC3	6	cell cycle checkpoint; cytosol; nucleus; cytoplasm; mitotic cell cycle; protein binding;
CDC45	6	cell cycle checkpoint; nucleus; cytoplasm; centrosome; mitotic cell cycle; protein binding;
DCTN3	6	cytosol; condensed chromosome kinetochore; centrosome; mitotic cell cycle; spindle; protein binding;
PTTG1	6	cytosol; nucleus; cytoplasm; cell division; mitotic cell cycle; protein binding;
CEP57	6	cytosol; nucleus; cytoplasm; centrosome; mitotic cell cycle; protein binding;
WWOX	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
GSTP1	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
PARK2	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
CRYAB	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
PYCARD	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
TH	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
DCPS	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
STK11	5	mitochondrion; cytosol; nucleus; cytoplasm; protein binding;
CHEK1	5	cell cycle checkpoint; cytosol; nucleus; centrosome; protein binding;
TUBGCP2	5	cytosol; nucleus; centrosome; mitotic cell cycle; protein binding;
CDK5RAP2	5	cytosol; cytoplasm; centrosome; mitotic cell cycle; protein binding;
CENPN	5	cytosol; condensed chromosome kinetochore; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
PSRC1	5	cytosol; cytoplasm; cell division; spindle; protein binding;
CNTRL	5	cytosol; centrosome; cell division; mitotic cell cycle; protein binding;
TNFAIP3	5	cytosol; nucleus; cytoplasm; centrosome; protein binding;
RAN	5	cytosol; cytoplasm; cell division; protein binding; nuclear pore;
KIF22	5	cytosol; nucleus; cytoplasm; spindle; kinetochore;
PPP1CA	5	cytosol; nucleus; cytoplasm; cell division; protein binding;
CENPL	5	cytosol; M phase of mitotic cell cycle; nucleus; mitotic prometaphase; mitotic cell cycle;
TUBG1	5	cytosol; cytoplasm; centrosome; mitotic cell cycle; protein binding;
CCND1	5	cytosol; nucleus; cell division; mitotic cell cycle; protein binding;
CENPJ	5	cytosol; centrosome; cell division; mitotic cell cycle; protein binding;
BAIAP2	5	cytosol; nucleus; cytoplasm; actin cytoskeleton; protein binding;
GSK3B	5	cytosol; nucleus; cytoplasm; centrosome; protein binding;
CENPV	5	condensed chromosome kinetochore; nucleus; cytoplasm; cell division; kinetochore;
CENPW	5	condensed chromosome kinetochore; cell division; mitotic cell cycle; protein binding; kinetochore;
SAC3D1	5	cytoplasm; centrosome; cell division; spindle; protein binding;

Genes shared at least 2 KEGG pathways with MAD1L1 (count: 0)

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Region: chr7:1855429..2272878 View in gBrowse