ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ETV5
Symbol Alias	ERM
Approved Name	ets variant 5
Previous Name	"ets variant gene 5 (ets-related molecule)"
Name Alias	"ets-related molecule"
Location	3q28
Position	chr3:185764097-185828107, -1
External Links	HGNC: 3494 Entrez Gene: 2119 Ensembl: ENSG00000244405 UCSC: uc003fpz.3
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Albayrak O., 2013	Association with an increased risk in this gene for ADHD for the obesity risk allele was detected before multiple correction.	Significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9816226	chr3:185834499(Fwd)	intron_variant; nc_transcript_variant	1(1/0/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003677	DNA binding	molecular function	TAS[8152800]	257
GO:0005634	nucleus	cellular component	IDA[19443906]	877
GO:0060762	regulation of branching involved in mammary gland duct morphogenesis	biological process	IEA	2
GO:0048133	male germ-line stem cell division	biological process	IEA	2
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IEA	89
GO:0050807	regulation of synapse organization	biological process	IEA	1
GO:0034599	cellular response to oxidative stress	biological process	IDA[19443906]	7
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[19443906]	28
GO:0071340	skeletal muscle acetylcholine-gated channel clustering	biological process	IEA	3
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IDA[19443906]	148
GO:0060252	positive regulation of glial cell proliferation	biological process	IEA	1
GO:0043565	sequence-specific DNA binding	molecular function	IEA	80
GO:0007610	behavior	biological process	IEA	12
GO:0007274	neuromuscular synaptic transmission	biological process	IEA	6
GO:0045666	positive regulation of neuron differentiation	biological process	IEA	13

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ETV5 (count: 11)

Gene Symbol	Pathway Count	Pathway List
HNF1B	6	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
RELA	6	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TBX1	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
TFAP2B	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXF1	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding;
HOXA13	5	DNA binding; nucleus; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HINFP	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity;
TFAP4	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding;
ETS1	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXE1	5	DNA binding; nucleus; positive regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
FOXC2	5	nucleus; positive regulation of transcription, DNA-dependent; transcription regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with ETV5 (count: 0)

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Region: chr3:185764097..185828107 View in gBrowse