ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DSCC1
Symbol Alias	DCC1, hDCC1, MGC5528
Approved Name	DNA replication and sister chromatid cohesion 1
Previous Name	"defective in sister chromatid cohesion 1 homolog (S. cerevisiae)"
Name Alias	"defective in sister chromatid cohesion homolog 1 (S. cerevisiae)"
Location	8q24.12
Position	chr8:120846216-120868250, -1
External Links	HGNC: 24453 Entrez Gene: 79075 Ensembl: ENSG00000136982 UCSC: uc003yov.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Yang L, 2013	Gene with smallest SNP P-value=0.0000738, no significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 19)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6469852	chr8:120860735(Fwd)	downstream_gene_variant; intron_variant	1(0/1/0)
rs3812463	chr8:120852100(Fwd)	intron_variant	1(0/1/0)
rs6469849	chr8:120857169(Fwd)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs12707880	chr8:120841291(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs10108071	chr8:120841323(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs1055130	chr8:120847188(Fwd)	missense_variant; upstream_gene_variant
rs6983932	chr8:120862080(Fwd)	downstream_gene_variant; intron_variant
rs6469853	chr8:120861813(Fwd)	downstream_gene_variant; intron_variant
rs1828238	chr8:120860345(Fwd)	downstream_gene_variant; intron_variant
rs13272214	chr8:120859539(Fwd)	intron_variant
rs7813680	chr8:120851405(Fwd)	intron_variant
rs1055131	chr8:120847123(Fwd)	3_prime_UTR_variant; upstream_gene_variant
rs1055133	chr8:120847078(Fwd)	3_prime_UTR_variant; upstream_gene_variant
rs7017279	chr8:120859820(Fwd)	intron_variant
rs12542706	chr8:120843779(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs14027	chr8:120846589(Fwd)	3_prime_UTR_variant; upstream_gene_variant
rs10505374	chr8:120844590(Fwd)	downstream_gene_variant; intron_variant; NMD_transcript_variant
rs7813651	chr8:120851359(Fwd)	intron_variant
rs7833112	chr8:120848082(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003677	DNA binding	molecular function	IEA	257
GO:0005515	protein binding	molecular function	IPI[16682347]	1015
GO:0006275	regulation of DNA replication	biological process	IMP[19907496]	4
GO:0000775	chromosome, centromeric region	cellular component	IDA[16682347]	10
GO:0005654	nucleoplasm	cellular component	IDA[16682347]	210
GO:0034088	maintenance of mitotic sister chromatid cohesion	biological process	IMP[19907496]	3
GO:0000785	chromatin	cellular component	IDA[19907496]	16
GO:0006260	DNA replication	biological process	IEA	31
GO:0034421	post-translational protein acetylation	biological process	IMP[19907496]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DSCC1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
SMC3	5	protein binding; regulation of DNA replication; chromosome, centromeric region; nucleoplasm; chromatin;

Genes shared at least 2 KEGG pathways with DSCC1 (count: 0)

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Region: chr8:120846216..120868250 View in gBrowse