ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CREBBP
Previous Symbol	RSTS
Symbol Alias	RTS, CBP, KAT3A
Approved Name	CREB binding protein
Previous Name	"Rubinstein-Taybi syndrome"
Location	16p13.3
Position	chr16:3775055-3930727, -1
External Links	HGNC: 2348 Entrez Gene: 1387 Ensembl: ENSG00000005339 UCSC: uc002cvv.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13	chr16:0-16800000	3 (2/1/0)
16p13.3	chr16:0-7900000	1 (1/0/0)

Gene related GO terms (count: 47)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 47)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	44
GO:0005737	cytoplasm	cellular component	IDA[12929931]	781
GO:0005515	protein binding	molecular function	IPI[16043483]	1015
GO:0002039	p53 binding	molecular function	IPI[9194565]	15
GO:0001105	RNA polymerase II transcription coactivator activity	molecular function	TAS[11001584]	3
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA	90
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0019048	virus-host interaction	biological process	IEA	61
GO:0003713	transcription coactivator activity	molecular function	IDA[12169688]; IDA[12929931]; IPI[8684459]	58
GO:0001666	response to hypoxia	biological process	TAS[15261140]	41
GO:0016604	nuclear body	cellular component	IDA[15488321]	5
GO:0000123	histone acetyltransferase complex	cellular component	IEA	3
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA	7
GO:0001085	RNA polymerase II transcription factor binding	molecular function	IPI	11
GO:0010467	gene expression	biological process	TAS	154
GO:0045893	positive regulation of transcription, DNA-dependent	biological process	IDA[11742995]; ISS	89
GO:0001102	RNA polymerase II activating transcription factor binding	molecular function	TAS[11001584]	6
GO:0006355	regulation of transcription, DNA-dependent	biological process	IDA[12169688]; TAS[15261140]	182
GO:0000987	core promoter proximal region sequence-specific DNA binding	molecular function	IDA	2
GO:0008589	regulation of smoothened signaling pathway	biological process	TAS[11001584]	4
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription	molecular function	IDA	2
GO:0071456	cellular response to hypoxia	biological process	TAS	14
GO:0008134	transcription factor binding	molecular function	IPI[15509593]	44
GO:0033554	cellular response to stress	biological process	TAS	14
GO:0000940	condensed chromosome outer kinetochore	cellular component	IEA	3
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	biological process	TAS	7
GO:0005667	transcription factor complex	cellular component	IEA	52
GO:0006461	protein complex assembly	biological process	TAS[7913207]	32
GO:0003682	chromatin binding	molecular function	IEA	50
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0030718	germ-line stem cell maintenance	biological process	IEA	1
GO:0018076	N-terminal peptidyl-lysine acetylation	biological process	IDA[12435739]	1
GO:0005634	nucleus	cellular component	IC[12169688]; IDA[12929931]	877
GO:0007219	Notch signaling pathway	biological process	TAS	23
GO:0000790	nuclear chromatin	cellular component	IDA	12
GO:0042733	embryonic digit morphogenesis	biological process	TAS[11001584]	4
GO:0016573	histone acetylation	biological process	IDA[11742995]	4
GO:0045087	innate immune response	biological process	TAS	57
GO:0043426	MRF binding	molecular function	IDA[8621548]	2
GO:0004871	signal transducer activity	molecular function	TAS[8028671]	56
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	TAS[7913207]	148
GO:0007165	signal transduction	biological process	NAS[15261140]	189
GO:0016407	acetyltransferase activity	molecular function	IDA[11742995]	3
GO:0042592	homeostatic process	biological process	NAS[15261140]	1
GO:0044255	cellular lipid metabolic process	biological process	TAS	33
GO:0004402	histone acetyltransferase activity	molecular function	IDA[11742995]	11
GO:0008270	zinc ion binding	molecular function	IEA	367

Gene related KEGG pathways (count: 12)

ID	Name	No. of Genes in ADHDgene
hsa05040	Huntington's disease	5
hsa04720	Long-term potentiation	16
hsa04520	Adherens junction	15
hsa04916	Melanogenesis	18
hsa05211	Renal cell carcinoma	15
hsa04110	Cell cycle	19
hsa04630	Jak-STAT signaling pathway	25
hsa04330	Notch signaling pathway	9
hsa05215	Prostate cancer	16
hsa04310	Wnt signaling pathway	25
hsa04350	TGF-beta signaling pathway	11
hsa01510	Neurodegenerative Diseases	8

Genes shared at least 5 GO terms with CREBBP (count: 197)

Gene Symbol	Pathway Count	Pathway List
MED1	12	transcription initiation from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; transcription factor binding; chromatin binding; small molecule metabolic process; nucleus; cellular lipid metabolic process;
KDM1A	12	protein binding; p53 binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; RNA polymerase II transcription factor binding; transcription factor binding; transcription factor complex; chromatin binding; nucleus; nuclear chromatin; MRF binding; sequence-specific DNA binding transcription factor activity;
NCOR2	11	transcription initiation from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nuclear body; gene expression; chromatin binding; small molecule metabolic process; nucleus; Notch signaling pathway; cellular lipid metabolic process;
RELA	11	cytoplasm; protein binding; nucleoplasm; virus-host interaction; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; chromatin binding; nucleus; innate immune response; sequence-specific DNA binding transcription factor activity;
UBC	10	transcription initiation from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; cellular response to hypoxia; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; Notch signaling pathway; innate immune response;
NR4A2	10	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; nucleoplasm; response to hypoxia; gene expression; cellular response to stress; nucleus; signal transduction; zinc ion binding;
NCOA6	10	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; transcription coactivator activity; positive regulation of transcription, DNA-dependent; transcription factor complex; chromatin binding; small molecule metabolic process; nucleus; cellular lipid metabolic process;
UBB	10	transcription initiation from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; cellular response to hypoxia; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; Notch signaling pathway; innate immune response;
SMARCD3	10	cytoplasm; protein binding; nucleoplasm; transcription coactivator activity; positive regulation of transcription, DNA-dependent; transcription factor binding; small molecule metabolic process; nucleus; nuclear chromatin; cellular lipid metabolic process;
GATA6	10	protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; cellular response to hypoxia; transcription factor binding; transcription factor complex; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
HMGA1	10	protein binding; nucleoplasm; virus-host interaction; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; protein complex assembly; nucleus; sequence-specific DNA binding transcription factor activity;
SNW1	9	transcription initiation from RNA polymerase II promoter; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; virus-host interaction; transcription coactivator activity; gene expression; nucleus; Notch signaling pathway;
RBPJ	9	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; nucleus; Notch signaling pathway; sequence-specific DNA binding transcription factor activity;
TAF10	9	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; nucleoplasm; transcription coactivator activity; gene expression; nucleus; sequence-specific DNA binding transcription factor activity; histone acetyltransferase activity;
YAP1	9	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; nucleoplasm; transcription coactivator activity; gene expression; transcription factor complex; chromatin binding; nucleus;
ZFPM1	9	cytoplasm; protein binding; nucleoplasm; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; RNA polymerase II transcription factor binding; RNA polymerase II activating transcription factor binding; transcription factor binding; transcription factor complex; zinc ion binding;
HES1	9	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; transcription factor binding; protein complex assembly; nucleus; Notch signaling pathway; sequence-specific DNA binding transcription factor activity;
RAN	9	cytoplasm; protein binding; nucleoplasm; virus-host interaction; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; chromatin binding; signal transduction;
MAPK1	9	cytoplasm; protein binding; nucleoplasm; virus-host interaction; positive regulation of transcription, DNA-dependent; transcription factor binding; nucleus; innate immune response; signal transduction;
HINFP	9	protein binding; nucleoplasm; transcription coactivator activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
KAT5	9	protein binding; negative regulation of transcription from RNA polymerase II promoter; virus-host interaction; transcription coactivator activity; positive regulation of transcription, DNA-dependent; transcription factor complex; nucleus; histone acetylation; histone acetyltransferase activity;
PGR	8	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; nucleoplasm; gene expression; nucleus; signal transduction; zinc ion binding;
NEDD4L	8	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; virus-host interaction; gene expression; nucleus;
MEN1	8	transcription initiation from RNA polymerase II promoter; cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; chromatin binding; nucleus;
NR5A1	8	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; transcription coactivator activity; gene expression; chromatin binding; nucleus; zinc ion binding;
EGLN3	8	cytoplasm; protein binding; nucleoplasm; response to hypoxia; cellular response to hypoxia; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; nucleus;
E4F1	8	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; virus-host interaction; transcription coactivator activity; sequence-specific DNA binding transcription factor activity; zinc ion binding;
HEY2	8	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II activating transcription factor binding; transcription factor binding; nucleus; Notch signaling pathway; sequence-specific DNA binding transcription factor activity;
LPIN1	8	cytoplasm; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; RNA polymerase II transcription factor binding; transcription factor complex; small molecule metabolic process; nucleus; cellular lipid metabolic process;
APBB1	8	cytoplasm; protein binding; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription factor binding; chromatin binding; nucleus; signal transduction;
ISL1	8	cytoplasm; RNA polymerase II transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II activating transcription factor binding; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
PSMC3	8	cytoplasm; protein binding; nucleoplasm; virus-host interaction; transcription coactivator activity; gene expression; small molecule metabolic process; nucleus;
MTA2	8	protein binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; transcription factor complex; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
TFAP2B	8	protein binding; RNA polymerase II transcription coactivator activity; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
TLE1	8	protein binding; nucleoplasm; transcription factor binding; transcription factor complex; chromatin binding; nucleus; Notch signaling pathway; signal transduction;
KAT8	8	protein binding; histone acetyltransferase complex; positive regulation of transcription, DNA-dependent; transcription factor binding; nucleus; histone acetylation; acetyltransferase activity; histone acetyltransferase activity;
RNF20	8	protein binding; p53 binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin binding; nucleus; zinc ion binding;
KLF4	8	negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; positive regulation of transcription, DNA-dependent; core promoter proximal region sequence-specific DNA binding; transcription factor complex; nuclear chromatin; sequence-specific DNA binding transcription factor activity; zinc ion binding;
MED12	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; chromatin binding; nucleus;
MED17	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; transcription factor complex; nucleus;
MED24	7	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; histone acetyltransferase activity;
MED27	7	transcription initiation from RNA polymerase II promoter; cytoplasm; nucleoplasm; transcription coactivator activity; gene expression; transcription factor complex; nucleus;
MAML1	7	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; transcription coactivator activity; gene expression; nucleus; Notch signaling pathway;
NR3C2	7	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; sequence-specific DNA binding transcription factor activity; signal transduction; zinc ion binding;
TAF4B	7	transcription initiation from RNA polymerase II promoter; cytoplasm; nucleoplasm; gene expression; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MED23	7	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; transcription coactivator activity; gene expression; regulation of transcription, DNA-dependent; transcription factor complex;
RORA	7	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; sequence-specific DNA binding transcription factor activity; signal transduction; zinc ion binding;
CBL	7	cytoplasm; protein binding; regulation of transcription, DNA-dependent; nucleus; signal transducer activity; sequence-specific DNA binding transcription factor activity; zinc ion binding;
VEGFA	7	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; response to hypoxia; cellular response to hypoxia; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia;
SSRP1	7	cytoplasm; protein binding; nucleoplasm; gene expression; regulation of transcription, DNA-dependent; chromatin binding; nucleus;
IRF7	7	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; positive regulation of transcription, DNA-dependent; nucleus; innate immune response;
LPXN	7	cytoplasm; protein binding; regulation of transcription, DNA-dependent; protein complex assembly; nucleus; signal transduction; zinc ion binding;
BNIP3	7	cytoplasm; protein binding; nucleoplasm; virus-host interaction; response to hypoxia; cellular response to hypoxia; nucleus;
DAXX	7	cytoplasm; protein binding; p53 binding; virus-host interaction; regulation of transcription, DNA-dependent; transcription factor binding; nucleus;
RREB1	7	cytoplasm; nuclear body; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
AIP	7	cytoplasm; protein binding; transcription coactivator activity; transcription factor binding; nucleus; signal transducer activity; signal transduction;
TP53BP1	7	cytoplasm; protein binding; p53 binding; nucleoplasm; positive regulation of transcription, DNA-dependent; RNA polymerase II activating transcription factor binding; nucleus;
ETS1	7	protein binding; response to hypoxia; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
TCEB1	7	protein binding; nucleoplasm; virus-host interaction; gene expression; cellular response to hypoxia; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia;
TCEB2	7	protein binding; nucleoplasm; gene expression; cellular response to hypoxia; cellular response to stress; regulation of transcription from RNA polymerase II promoter in response to hypoxia; protein complex assembly;
PRKAA1	7	protein binding; response to hypoxia; regulation of transcription, DNA-dependent; cellular response to hypoxia; chromatin binding; nucleus; signal transduction;
FOXC2	7	negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus; Notch signaling pathway; sequence-specific DNA binding transcription factor activity;
CLOCK	7	regulation of transcription, DNA-dependent; transcription factor complex; nucleus; signal transducer activity; sequence-specific DNA binding transcription factor activity; signal transduction; histone acetyltransferase activity;
MED16	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; nucleus;
TAF13	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; nucleus; sequence-specific DNA binding transcription factor activity;
MED14	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; nucleus;
MED30	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; positive regulation of transcription, DNA-dependent; nucleus;
MAML2	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; nucleus; Notch signaling pathway;
ESRRA	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; nucleus; zinc ion binding;
MED7	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; transcription coactivator activity; gene expression; transcription factor complex;
MED13	6	transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; gene expression; positive regulation of transcription, DNA-dependent; nucleus;
MED4	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; positive regulation of transcription, DNA-dependent; nucleus;
NR6A1	6	transcription initiation from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; gene expression; transcription factor complex; zinc ion binding;
SMC1A	6	cytoplasm; protein binding; nucleoplasm; gene expression; chromatin binding; nucleus;
DHX9	6	cytoplasm; protein binding; nucleoplasm; RNA polymerase II transcription factor binding; gene expression; nucleus;
TRIM22	6	cytoplasm; virus-host interaction; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
UBE2I	6	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; virus-host interaction; transcription factor binding; nucleus;
FOXP2	6	cytoplasm; transcription factor binding; transcription factor complex; chromatin binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;
PRKD1	6	cytoplasm; protein binding; small molecule metabolic process; nucleus; innate immune response; signal transduction;
FUS	6	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus; zinc ion binding;
FOXP1	6	cytoplasm; transcription factor binding; transcription factor complex; chromatin binding; nucleus; zinc ion binding;
TRIM29	6	cytoplasm; protein binding; p53 binding; negative regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding transcription factor activity; zinc ion binding;
RBM4	6	cytoplasm; protein binding; nucleoplasm; cellular response to stress; nucleus; zinc ion binding;
ARRB1	6	cytoplasm; protein binding; transcription factor binding; nucleus; Notch signaling pathway; histone acetyltransferase activity;
STRN3	6	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
XPO1	6	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; virus-host interaction; gene expression;
IGHMBP2	6	cytoplasm; protein binding; regulation of transcription, DNA-dependent; transcription factor binding; nucleus; zinc ion binding;
GRHL1	6	cytoplasm; nucleoplasm; regulation of transcription, DNA-dependent; small molecule metabolic process; nucleus; cellular lipid metabolic process;
TRIM32	6	cytoplasm; protein binding; transcription coactivator activity; nucleus; innate immune response; zinc ion binding;
TRIM5	6	cytoplasm; protein binding; virus-host interaction; nucleus; innate immune response; zinc ion binding;
RCC1	6	cytoplasm; protein binding; nucleoplasm; chromatin binding; nucleus; nuclear chromatin;
SOX8	6	cytoplasm; positive regulation of transcription, DNA-dependent; transcription factor binding; nucleus; sequence-specific DNA binding transcription factor activity; signal transduction;
AXIN1	6	cytoplasm; protein binding; p53 binding; positive regulation of transcription, DNA-dependent; nucleus; signal transducer activity;
SMC3	6	cytoplasm; protein binding; nucleoplasm; chromatin binding; nucleus; signal transduction;
TXN	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; small molecule metabolic process; innate immune response; signal transduction;
MYB	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; chromatin binding; sequence-specific DNA binding transcription factor activity;
KMT2A	6	protein binding; positive regulation of transcription, DNA-dependent; protein complex assembly; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
GFI1B	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; transcription factor complex; nucleus; zinc ion binding;
SMARCB1	6	protein binding; p53 binding; nucleoplasm; virus-host interaction; transcription coactivator activity; nucleus;
MAPK3	6	protein binding; nucleoplasm; virus-host interaction; gene expression; nucleus; innate immune response;
HNF1B	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
SPI1	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; positive regulation of transcription, DNA-dependent; nuclear chromatin; sequence-specific DNA binding transcription factor activity;
ATF6	6	protein binding; nucleoplasm; transcription coactivator activity; nucleus; sequence-specific DNA binding transcription factor activity; signal transduction;
RNF2	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; nuclear body; chromatin binding; nucleus; zinc ion binding;
EEF1D	6	protein binding; gene expression; regulation of transcription, DNA-dependent; nucleus; signal transducer activity; signal transduction;
FOXE1	6	negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
TBX6	6	negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription factor binding; RNA polymerase II activating transcription factor binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription; nucleus; sequence-specific DNA binding transcription factor activity;
THRAP3	5	transcription initiation from RNA polymerase II promoter; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; nucleus;
MED15	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; nucleus;
MAZ	5	transcription initiation from RNA polymerase II promoter; protein binding; regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
GTF2H3	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; regulation of transcription, DNA-dependent; sequence-specific DNA binding transcription factor activity;
CD2BP2	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
FANCC	5	cytoplasm; protein binding; nucleoplasm; protein complex assembly; nucleus;
STK11	5	cytoplasm; protein binding; p53 binding; small molecule metabolic process; nucleus;
HOXA11	5	cytoplasm; positive regulation of transcription, DNA-dependent; transcription factor complex; embryonic digit morphogenesis; sequence-specific DNA binding transcription factor activity;
TH	5	cytoplasm; protein binding; response to hypoxia; small molecule metabolic process; nucleus;
IKBKAP	5	cytoplasm; protein binding; protein complex assembly; signal transducer activity; signal transduction;
MMS19	5	cytoplasm; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; nucleus;
NUP62	5	cytoplasm; protein binding; positive regulation of transcription, DNA-dependent; chromatin binding; small molecule metabolic process;
DEAF1	5	cytoplasm; protein binding; transcription factor complex; nucleus; zinc ion binding;
GEMIN2	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
ZNF263	5	cytoplasm; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
POU2F3	5	cytoplasm; protein binding; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
MTA3	5	cytoplasm; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
SKOR1	5	cytoplasm; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription factor complex; nucleus;
PRDM1	5	cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
TCF25	5	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
TNFAIP3	5	cytoplasm; protein binding; nucleus; innate immune response; zinc ion binding;
EFTUD2	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
TRAF1	5	cytoplasm; protein binding; protein complex assembly; signal transduction; zinc ion binding;
TFEB	5	cytoplasm; regulation of transcription, DNA-dependent; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
FANCA	5	cytoplasm; protein binding; nucleoplasm; protein complex assembly; nucleus;
UBE3A	5	cytoplasm; protein binding; virus-host interaction; transcription coactivator activity; nucleus;
RNPS1	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
IRF9	5	cytoplasm; protein binding; nucleoplasm; nucleus; sequence-specific DNA binding transcription factor activity;
PYCARD	5	cytoplasm; protein binding; nucleus; innate immune response; signal transduction;
MKL2	5	cytoplasm; protein binding; transcription coactivator activity; nucleus; sequence-specific DNA binding transcription factor activity;
PTTG1	5	cytoplasm; protein binding; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
TGFB1I1	5	cytoplasm; protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; zinc ion binding;
ADAM17	5	cytoplasm; protein binding; response to hypoxia; Notch signaling pathway; zinc ion binding;
ZNF174	5	cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
MALT1	5	cytoplasm; protein binding; nucleus; innate immune response; signal transducer activity;
GLIS2	5	cytoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
HNRNPH1	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
DGCR8	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
NEK6	5	cytoplasm; protein binding; nucleus; signal transducer activity; signal transduction;
RCHY1	5	cytoplasm; protein binding; p53 binding; nucleus; zinc ion binding;
ID2	5	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; nucleus;
HNRNPA1	5	cytoplasm; nucleoplasm; virus-host interaction; gene expression; nucleus;
TRIM13	5	cytoplasm; protein binding; signal transducer activity; signal transduction; zinc ion binding;
IKZF1	5	cytoplasm; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
DDB1	5	cytoplasm; protein binding; nucleoplasm; virus-host interaction; nucleus;
GSK3B	5	cytoplasm; protein binding; p53 binding; RNA polymerase II transcription factor binding; nucleus;
HOXA9	5	cytoplasm; protein binding; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
CDCA5	5	cytoplasm; protein binding; chromatin binding; nucleus; nuclear chromatin;
UXT	5	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus;
HNRNPA2B1	5	cytoplasm; protein binding; nucleoplasm; gene expression; nucleus;
DNAJA3	5	cytoplasm; protein binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; nucleus;
TERF2IP	5	cytoplasm; protein binding; nucleoplasm; regulation of transcription, DNA-dependent; nucleus;
CTNND2	5	cytoplasm; protein binding; regulation of transcription, DNA-dependent; nucleus; signal transduction;
MAPK7	5	protein binding; nucleoplasm; nucleus; innate immune response; signal transduction;
TFAP4	5	protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; protein complex assembly; nucleus;
U2AF1	5	protein binding; nucleoplasm; gene expression; nucleus; zinc ion binding;
LMX1B	5	protein binding; regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
PSMB7	5	protein binding; nucleoplasm; virus-host interaction; gene expression; small molecule metabolic process;
PRPF6	5	protein binding; nucleoplasm; transcription coactivator activity; gene expression; nucleus;
CREB5	5	protein binding; positive regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; zinc ion binding;
CBFA2T3	5	protein binding; nucleoplasm; chromatin binding; sequence-specific DNA binding transcription factor activity; zinc ion binding;
PRKAB2	5	protein binding; nucleoplasm; small molecule metabolic process; signal transduction; cellular lipid metabolic process;
ZBTB16	5	protein binding; nuclear body; positive regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
MEIS2	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; transcription factor binding; nucleus; sequence-specific DNA binding transcription factor activity;
CIITA	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription coactivator activity; positive regulation of transcription, DNA-dependent;
MAVS	5	protein binding; virus-host interaction; innate immune response; signal transducer activity; signal transduction;
ZNF423	5	protein binding; positive regulation of transcription, DNA-dependent; nucleus; Notch signaling pathway; zinc ion binding;
FOXG1	5	protein binding; regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus;
BIRC2	5	protein binding; transcription coactivator activity; regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
RSF1	5	protein binding; nucleoplasm; positive regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
HIRA	5	protein binding; chromatin binding; nucleus; nuclear chromatin; sequence-specific DNA binding transcription factor activity;
WASL	5	protein binding; regulation of transcription, DNA-dependent; protein complex assembly; small molecule metabolic process; nucleus;
NRIP1	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; positive regulation of transcription, DNA-dependent; nucleus;
ZNF205	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
SF3A3	5	protein binding; nucleoplasm; gene expression; nucleus; zinc ion binding;
SREBF1	5	protein binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity;
USP7	5	protein binding; p53 binding; virus-host interaction; transcription factor binding; nucleus;
NPAT	5	protein binding; transcription coactivator activity; positive regulation of transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MAP2K3	5	protein binding; nucleoplasm; positive regulation of transcription, DNA-dependent; innate immune response; signal transduction;
MAPK9	5	protein binding; nucleoplasm; positive regulation of transcription, DNA-dependent; transcription factor binding; innate immune response;
NSD1	5	negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; chromatin binding; nucleus; zinc ion binding;
FOXF1	5	negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus;
TLE4	5	negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; chromatin binding; nucleus; Notch signaling pathway;
GTF3A	5	nucleoplasm; gene expression; regulation of transcription, DNA-dependent; nucleus; zinc ion binding;
SRCAP	5	virus-host interaction; transcription coactivator activity; nucleus; histone acetylation; histone acetyltransferase activity;
SUPT3H	5	transcription coactivator activity; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleus; histone acetyltransferase activity;
FOXD4	5	regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
FOXL1	5	regulation of transcription, DNA-dependent; transcription factor binding; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
NPAS2	5	transcription factor complex; small molecule metabolic process; signal transducer activity; sequence-specific DNA binding transcription factor activity; cellular lipid metabolic process;
TADA2A	5	chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; histone acetyltransferase activity; zinc ion binding;

Genes shared at least 2 KEGG pathways with CREBBP (count: 23)

Gene Symbol	Pathway Count	Pathway List
MAPK3	6	Long-term potentiation; Adherens junction; Melanogenesis; Renal cell carcinoma; Prostate cancer; TGF-beta signaling pathway;
MAPK1	6	Long-term potentiation; Adherens junction; Melanogenesis; Renal cell carcinoma; Prostate cancer; TGF-beta signaling pathway;
GSK3B	4	Melanogenesis; Cell cycle; Prostate cancer; Wnt signaling pathway;
CCND1	4	Cell cycle; Jak-STAT signaling pathway; Prostate cancer; Wnt signaling pathway;
PLCB2	3	Long-term potentiation; Melanogenesis; Wnt signaling pathway;
CAMK2D	3	Long-term potentiation; Melanogenesis; Wnt signaling pathway;
PLCB3	3	Long-term potentiation; Melanogenesis; Wnt signaling pathway;
PIK3CG	3	Renal cell carcinoma; Jak-STAT signaling pathway; Prostate cancer;
PIK3R1	3	Renal cell carcinoma; Jak-STAT signaling pathway; Prostate cancer;
CCND3	3	Cell cycle; Jak-STAT signaling pathway; Wnt signaling pathway;
CASP1	2	Huntington's disease; Neurodegenerative Diseases;
ADCY3	2	Long-term potentiation; Melanogenesis;
PPP3R2	2	Long-term potentiation; Wnt signaling pathway;
ERBB2	2	Adherens junction; Prostate cancer;
TGFBR1	2	Adherens junction; TGF-beta signaling pathway;
WNT10A	2	Melanogenesis; Wnt signaling pathway;
WNT11	2	Melanogenesis; Wnt signaling pathway;
WNT6	2	Melanogenesis; Wnt signaling pathway;
FZD4	2	Melanogenesis; Wnt signaling pathway;
BAD	2	Prostate cancer; Neurodegenerative Diseases;
ROCK2	2	Wnt signaling pathway; TGF-beta signaling pathway;
PPP2R2C	2	Wnt signaling pathway; TGF-beta signaling pathway;
PPP2R1B	2	Wnt signaling pathway; TGF-beta signaling pathway;

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Region: chr16:3775055..3930727 View in gBrowse