ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol ASTN2
Symbol Alias KIAA0634
Approved Name astrotactin 2
Location 9q33
Position chr9:119187504-120177348, -
External Links HGNC: 17021
Entrez Gene: 23245
Ensembl: ENSG00000148219
UCSC: uc004bjs.1
No. of Studies 2 (significant: 0; non-significant: 0; trend: 2)
Source Literature-origin; Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 2)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Lesch KP, 2008 Trend associated SNP was mapped in this gene. Trend
Lionel, A. C., 2011 Rare inherited CNVs in ADHD probands which absent in controls overlapped with ASTN2, which indicate it a new candidate susceptibility gene for ADHD. De novo and/or rare inherited CNVs associated with this gene were detected for not only ADHD, but also other neurodevelopmental conditions including ASD. Tests in a newly collected cohort of 349 unrelated individuals with ASD showed that deletions of ASTN2 yielded the strongest association with ADHD and ASD. Trend

Gene related SNPs (count: 22)

Literature-origin SNPs (count: 1)

LD-proxies (count: 21)

Gene related CNVs (count: 2)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Gene related GO terms (count: 1)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 1)

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ASTN2 (count: 0)

Genes shared at least 2 KEGG pathways with ASTN2 (count: 0)

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Region: chr9:119187504..120177348 View in gBrowse
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