ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARSB
Approved Name	arylsulfatase B
Location	5q14.1
Position	chr5:78073032-78281910, -1
External Links	HGNC: 714 Entrez Gene: 411 Ensembl: ENSG00000113273 UCSC: uc003kfq.3
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Yang L, 2013	Gene with smallest SNP P-value=0.00000994, indecated a trend association with ADHD.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs6453417	chr5:78110532(Fwd)	downstream_gene_variant; intron_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 27)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007041	lysosomal transport	biological process	TAS[2303452]	3
GO:0043627	response to estrogen stimulus	biological process	IEA	11
GO:0043687	post-translational protein modification	biological process	TAS	42
GO:0030203	glycosaminoglycan metabolic process	biological process	TAS	23
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005739	mitochondrion	cellular component	IEA	221
GO:0051597	response to methylmercury	biological process	IEA	3
GO:0006644	phospholipid metabolic process	biological process	TAS	61
GO:0030204	chondroitin sulfate metabolic process	biological process	TAS	9
GO:0005791	rough endoplasmic reticulum	cellular component	IEA	8
GO:0007040	lysosome organization	biological process	TAS[1718978]	9
GO:0006665	sphingolipid metabolic process	biological process	TAS	17
GO:0006687	glycosphingolipid metabolic process	biological process	TAS	10
GO:0009268	response to pH	biological process	IEA	3
GO:0005788	endoplasmic reticulum lumen	cellular component	TAS	35
GO:0004065	arylsulfatase activity	molecular function	IEA	2
GO:0006914	autophagy	biological process	IEA	16
GO:0005794	Golgi apparatus	cellular component	IEA	174
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0007584	response to nutrient	biological process	IEA	18
GO:0007417	central nervous system development	biological process	IEA	22
GO:0005975	carbohydrate metabolic process	biological process	TAS	59
GO:0003943	N-acetylgalactosamine-4-sulfatase activity	molecular function	TAS	2
GO:0030207	chondroitin sulfate catabolic process	biological process	TAS	2
GO:0043202	lysosomal lumen	cellular component	TAS	12
GO:0005764	lysosome	cellular component	TAS[2303452]	34
GO:0044267	cellular protein metabolic process	biological process	TAS	78

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01032	Glycan structures - degradation	4
hsa00531	Glycosaminoglycan degradation	3

Genes shared at least 5 GO terms with ARSB (count: 21)

Gene Symbol	Pathway Count	Pathway List
STS	10	post-translational protein modification; small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; endoplasmic reticulum lumen; Golgi apparatus; metal ion binding; lysosome; cellular protein metabolic process;
ARSJ	9	post-translational protein modification; small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; endoplasmic reticulum lumen; arylsulfatase activity; metal ion binding; cellular protein metabolic process;
SUMF1	8	post-translational protein modification; small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; endoplasmic reticulum lumen; metal ion binding; cellular protein metabolic process;
B4GALT4	6	post-translational protein modification; glycosaminoglycan metabolic process; small molecule metabolic process; metal ion binding; carbohydrate metabolic process; cellular protein metabolic process;
B4GALT6	6	post-translational protein modification; glycosaminoglycan metabolic process; small molecule metabolic process; metal ion binding; carbohydrate metabolic process; cellular protein metabolic process;
GALNS	6	glycosaminoglycan metabolic process; small molecule metabolic process; metal ion binding; carbohydrate metabolic process; N-acetylgalactosamine-4-sulfatase activity; lysosomal lumen;
NCAN	6	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; lysosomal lumen;
SMPD4	6	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; Golgi apparatus; metal ion binding;
ST3GAL4	5	post-translational protein modification; glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; cellular protein metabolic process;
B3GAT3	5	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; Golgi apparatus; carbohydrate metabolic process;
B3GAT1	5	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; metal ion binding; carbohydrate metabolic process;
DSE	5	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; Golgi apparatus; carbohydrate metabolic process;
GPC6	5	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; lysosomal lumen;
GPC5	5	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; carbohydrate metabolic process; lysosomal lumen;
CHPF	5	glycosaminoglycan metabolic process; small molecule metabolic process; chondroitin sulfate metabolic process; metal ion binding; carbohydrate metabolic process;
ENPP7	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; Golgi apparatus;
SMPD2	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; metal ion binding;
PRKD1	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; Golgi apparatus; metal ion binding;
NEU3	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; carbohydrate metabolic process;
SMPD1	5	small molecule metabolic process; phospholipid metabolic process; sphingolipid metabolic process; glycosphingolipid metabolic process; lysosomal lumen;
TPP1	5	mitochondrion; lysosome organization; metal ion binding; lysosomal lumen; lysosome;

Genes shared at least 2 KEGG pathways with ARSB (count: 2)

Gene Symbol	Pathway Count	Pathway List
GALNS	2	Glycan structures - degradation; Glycosaminoglycan degradation;
SPAM1	2	Glycan structures - degradation; Glycosaminoglycan degradation;

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Region: chr5:78073032..78281910 View in gBrowse