ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADCY2
Symbol Alias	HBAC2, KIAA1060, AC2
Approved Name	adenylate cyclase 2 (brain)
Location	5p15.3
Position	chr5:7396321-7830194, 1
External Links	HGNC: 233 Entrez Gene: 108 Ensembl: ENSG00000078295 UCSC: uc003jdz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p	chr5:0-48400000	1 (1/0/0)

Gene related GO terms (count: 32)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 32)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071377	cellular response to glucagon stimulus	biological process	TAS	9
GO:0055085	transmembrane transport	biological process	TAS	95
GO:0035556	intracellular signal transduction	biological process	IEA	52
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS	51
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0006171	cAMP biosynthetic process	biological process	ISS; NAS	3
GO:0004016	adenylate cyclase activity	molecular function	ISS; NAS[1427768]	4
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	TAS	11
GO:0005886	plasma membrane	cellular component	IDA[11549699]; TAS	839
GO:0030425	dendrite	cellular component	ISS	51
GO:0031683	G-protein beta/gamma-subunit complex binding	molecular function	IEA	5
GO:0007165	signal transduction	biological process	TAS	189
GO:0005524	ATP binding	molecular function	IEA	265
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	molecular function	IEA	1
GO:0016020	membrane	cellular component	ISS	155
GO:0007202	activation of phospholipase C activity	biological process	TAS	15
GO:0005622	intracellular	cellular component	ISS	83
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway	biological process	ISS	14
GO:0016021	integral to membrane	cellular component	NAS	932
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	32
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	TAS	10
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	33
GO:0034199	activation of protein kinase A activity	biological process	TAS	5
GO:0043234	protein complex	cellular component	IEA	47
GO:0008179	adenylate cyclase binding	molecular function	ISS	2
GO:0046982	protein heterodimerization activity	molecular function	ISS	73
GO:0005737	cytoplasm	cellular component	IDA[11549699]	781
GO:0045121	membrane raft	cellular component	ISS	24
GO:0007268	synaptic transmission	biological process	TAS	103
GO:0006112	energy reserve metabolic process	biological process	TAS	31
GO:0006833	water transport	biological process	TAS	9

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	27
hsa04540	Gap junction	30
hsa04916	Melanogenesis	18
hsa04912	GnRH signaling pathway	30
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with ADCY2 (count: 58)

Gene Symbol	Pathway Count	Pathway List
ADCY4	25	cellular response to glucagon stimulus; transmembrane transport; intracellular signal transduction; nerve growth factor receptor signaling pathway; small molecule metabolic process; cAMP biosynthetic process; adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; dendrite; signal transduction; ATP binding; metal ion binding; membrane; activation of phospholipase C activity; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; integral to membrane; epidermal growth factor receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; fibroblast growth factor receptor signaling pathway; activation of protein kinase A activity; cytoplasm; synaptic transmission; energy reserve metabolic process; water transport;
ADCY3	20	cellular response to glucagon stimulus; transmembrane transport; intracellular signal transduction; nerve growth factor receptor signaling pathway; small molecule metabolic process; adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; signal transduction; ATP binding; metal ion binding; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; fibroblast growth factor receptor signaling pathway; activation of protein kinase A activity; cytoplasm; synaptic transmission; energy reserve metabolic process; water transport;
ADCY9	19	cellular response to glucagon stimulus; transmembrane transport; intracellular signal transduction; nerve growth factor receptor signaling pathway; small molecule metabolic process; adenylate cyclase activity; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; signal transduction; ATP binding; metal ion binding; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; fibroblast growth factor receptor signaling pathway; activation of protein kinase A activity; synaptic transmission; energy reserve metabolic process; water transport;
PRKAR2B	15	cellular response to glucagon stimulus; transmembrane transport; intracellular signal transduction; nerve growth factor receptor signaling pathway; small molecule metabolic process; plasma membrane; signal transduction; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; activation of protein kinase A activity; cytoplasm; membrane raft; energy reserve metabolic process; water transport;
ITPR2	9	nerve growth factor receptor signaling pathway; small molecule metabolic process; plasma membrane; signal transduction; activation of phospholipase C activity; integral to membrane; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; energy reserve metabolic process;
ADRBK1	9	nerve growth factor receptor signaling pathway; plasma membrane; signal transduction; ATP binding; membrane; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytoplasm;
PDPK1	8	intracellular signal transduction; nerve growth factor receptor signaling pathway; plasma membrane; ATP binding; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytoplasm; synaptic transmission;
GSK3B	8	intracellular signal transduction; nerve growth factor receptor signaling pathway; plasma membrane; ATP binding; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytoplasm; membrane raft;
MAPK1	8	nerve growth factor receptor signaling pathway; signal transduction; ATP binding; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; protein complex; cytoplasm; synaptic transmission;
ITPR1	8	nerve growth factor receptor signaling pathway; small molecule metabolic process; signal transduction; activation of phospholipase C activity; integral to membrane; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; energy reserve metabolic process;
ADORA2A	7	nerve growth factor receptor signaling pathway; cAMP biosynthetic process; adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; membrane; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; protein heterodimerization activity;
TSC2	7	nerve growth factor receptor signaling pathway; dendrite; membrane; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; protein heterodimerization activity; cytoplasm;
CACNA1A	7	small molecule metabolic process; plasma membrane; metal ion binding; integral to membrane; cytoplasm; synaptic transmission; energy reserve metabolic process;
CACNA1C	7	small molecule metabolic process; plasma membrane; metal ion binding; integral to membrane; cytoplasm; synaptic transmission; energy reserve metabolic process;
GNAL	7	adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; G-protein beta/gamma-subunit complex binding; signal transduction; metal ion binding; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; synaptic transmission;
GNG10	6	cellular response to glucagon stimulus; small molecule metabolic process; plasma membrane; signal transduction; synaptic transmission; energy reserve metabolic process;
RPS6KB2	6	nerve growth factor receptor signaling pathway; signal transduction; ATP binding; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; cytoplasm;
SNAP25	6	small molecule metabolic process; plasma membrane; membrane; cytoplasm; synaptic transmission; energy reserve metabolic process;
STX1A	6	small molecule metabolic process; plasma membrane; integral to membrane; protein heterodimerization activity; synaptic transmission; energy reserve metabolic process;
PRKD1	6	small molecule metabolic process; plasma membrane; signal transduction; ATP binding; metal ion binding; cytoplasm;
ADRA2A	6	small molecule metabolic process; plasma membrane; signal transduction; protein heterodimerization activity; cytoplasm; energy reserve metabolic process;
STK11	6	small molecule metabolic process; ATP binding; membrane; protein complex; cytoplasm; energy reserve metabolic process;
ERBB2	6	plasma membrane; signal transduction; ATP binding; integral to membrane; epidermal growth factor receptor signaling pathway; protein heterodimerization activity;
CHRNA4	6	plasma membrane; dendrite; signal transduction; membrane; integral to membrane; synaptic transmission;
GNG3	5	cellular response to glucagon stimulus; small molecule metabolic process; plasma membrane; synaptic transmission; energy reserve metabolic process;
SLC1A3	5	transmembrane transport; plasma membrane; membrane; integral to membrane; synaptic transmission;
ATP2B3	5	transmembrane transport; plasma membrane; ATP binding; metal ion binding; integral to membrane;
ABCG2	5	transmembrane transport; small molecule metabolic process; plasma membrane; ATP binding; integral to membrane;
ABCA3	5	transmembrane transport; plasma membrane; ATP binding; membrane; integral to membrane;
SLC6A1	5	transmembrane transport; plasma membrane; membrane; integral to membrane; synaptic transmission;
ABCG4	5	transmembrane transport; plasma membrane; ATP binding; integral to membrane; protein heterodimerization activity;
GABRA5	5	transmembrane transport; plasma membrane; dendrite; signal transduction; synaptic transmission;
SLC6A3	5	transmembrane transport; plasma membrane; integral to membrane; cytoplasm; synaptic transmission;
AQP4	5	transmembrane transport; plasma membrane; protein complex; cytoplasm; water transport;
UNC13C	5	intracellular signal transduction; plasma membrane; metal ion binding; cytoplasm; synaptic transmission;
DGKH	5	intracellular signal transduction; plasma membrane; ATP binding; metal ion binding; cytoplasm;
ITK	5	intracellular signal transduction; signal transduction; ATP binding; metal ion binding; activation of phospholipase C activity;
DGKG	5	intracellular signal transduction; plasma membrane; signal transduction; ATP binding; cytoplasm;
SORT1	5	nerve growth factor receptor signaling pathway; plasma membrane; dendrite; integral to membrane; cytoplasm;
ADAM17	5	nerve growth factor receptor signaling pathway; plasma membrane; epidermal growth factor receptor signaling pathway; cytoplasm; membrane raft;
FURIN	5	nerve growth factor receptor signaling pathway; plasma membrane; metal ion binding; integral to membrane; membrane raft;
PIK3R1	5	nerve growth factor receptor signaling pathway; small molecule metabolic process; plasma membrane; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
PNPLA8	5	small molecule metabolic process; ATP binding; membrane; intracellular; integral to membrane;
DBH	5	small molecule metabolic process; membrane; integral to membrane; cytoplasm; synaptic transmission;
CACNA1D	5	small molecule metabolic process; plasma membrane; metal ion binding; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; energy reserve metabolic process;
PIK3CG	5	small molecule metabolic process; plasma membrane; ATP binding; membrane; cytoplasm;
STS	5	small molecule metabolic process; plasma membrane; metal ion binding; membrane; integral to membrane;
ACHE	5	small molecule metabolic process; plasma membrane; dendrite; membrane; synaptic transmission;
CHRM3	5	small molecule metabolic process; plasma membrane; dendrite; signal transduction; energy reserve metabolic process;
ADRA2C	5	small molecule metabolic process; plasma membrane; protein heterodimerization activity; cytoplasm; energy reserve metabolic process;
ENPP1	5	small molecule metabolic process; plasma membrane; ATP binding; metal ion binding; integral to membrane;
CACNA1E	5	small molecule metabolic process; plasma membrane; metal ion binding; synaptic transmission; energy reserve metabolic process;
CHRNA3	5	plasma membrane; dendrite; signal transduction; integral to membrane; synaptic transmission;
KCNIP1	5	plasma membrane; dendrite; signal transduction; protein heterodimerization activity; synaptic transmission;
GNAZ	5	plasma membrane; G-protein beta/gamma-subunit complex binding; metal ion binding; adenylate cyclase-modulating G-protein coupled receptor signaling pathway; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway;
PAK1	5	plasma membrane; dendrite; ATP binding; protein complex; cytoplasm;
PANX1	5	plasma membrane; integral to membrane; protein complex; protein heterodimerization activity; synaptic transmission;
DTNA	5	plasma membrane; signal transduction; protein complex; cytoplasm; synaptic transmission;

Genes shared at least 2 KEGG pathways with ADCY2 (count: 22)

Gene Symbol	Pathway Count	Pathway List
ADCY9	5	Purine metabolism; Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ADCY4	5	Purine metabolism; Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ADCY3	5	Purine metabolism; Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
PLCB2	4	Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
PLCB3	4	Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ITPR1	3	Gap junction; GnRH signaling pathway; Calcium signaling pathway;
ITPR2	3	Gap junction; GnRH signaling pathway; Calcium signaling pathway;
MAPK3	3	Gap junction; Melanogenesis; GnRH signaling pathway;
MAPK1	3	Gap junction; Melanogenesis; GnRH signaling pathway;
CAMK2D	3	Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
GUCY1A2	2	Purine metabolism; Gap junction;
GRM5	2	Gap junction; Calcium signaling pathway;
ADRB1	2	Gap junction; Calcium signaling pathway;
DRD1	2	Gap junction; Calcium signaling pathway;
HTR2A	2	Gap junction; Calcium signaling pathway;
MAPK7	2	Gap junction; GnRH signaling pathway;
HTR2C	2	Gap junction; Calcium signaling pathway;
GRM1	2	Gap junction; Calcium signaling pathway;
CACNA1D	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1C	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1S	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1F	2	GnRH signaling pathway; Calcium signaling pathway;

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Region: chr5:7396321..7830194 View in gBrowse