ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs2535629 dbSNP Ensembl
Location	chr3:52833219(Fwd)
Variant Alleles	G/A
Ancestral Allele	A
Functional Annotation	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000467268) intron_variant(ENST00000416872; ENST00000449956; ENST00000463893; ENST00000465243) nc_transcript_variant(ENST00000463893; ENST00000465243) upstream_gene_variant(ENST00000464804; ENST00000465314; ENST00000475931; ENST00000495622)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
PGC, 2013	G/A		Five disorder meta-analysis, P-value=2.54E-12, OR (95% CI)=1...... Five disorder meta-analysis, P-value=2.54E-12, OR (95% CI)=1.10 (1.07-1.12), Heterogeneity P-value=0.27; for ADHD only, P-value=0.201 More...	Significant association was observed in cross-disorder analy...... Significant association was observed in cross-disorder analysis. More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
ITIH3	inter-alpha-trypsin inhibitor heavy chain 3	3p21.1	1(1/0/0)

Genes from other sources (count: 0)

SNPs in LD with rs2535629 (count: 101) View in gBrowse (chr3:52637486..52847601 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 101)

rs_ID	Functional Annotation	r²[population]
rs1108842	5_prime_UTR_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.83[CHB]
rs11716747	intron_variant	0.83[CHB]; 0.825[JPT]
rs1029871	downstream_gene_variant; missense_variant	0.83[CHB]; 0.825[JPT]
rs6445535	downstream_gene_variant; intron_variant	0.83[CHB]; 0.825[JPT]
rs3617	downstream_gene_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.911[CHB]; 0.838[CHD]; 0.953[JPT]; 0.912[GIH]; 0.878[LWK]; 0.889[YRI]
rs3733039	intron_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs11130310	intron_variant; NMD_transcript_variant	0.83[CHB]
rs3774366	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs35526119	intron_variant	0.83[CHB]; 0.825[JPT]
rs6804145	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2268023	downstream_gene_variant; intron_variant; upstream_gene_variant	0.862[CHB]; 0.865[JPT]
rs6762813	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs2268026	downstream_gene_variant; intron_variant; nc_transcript_variant	0.83[CHB]; 0.825[JPT]
rs3774354	downstream_gene_variant; intron_variant; upstream_gene_variant	0.862[CHB]; 0.82[CHD]; 0.865[JPT]
rs11177	downstream_gene_variant; missense_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.83[CHB]
rs2289250	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2230535	downstream_gene_variant; synonymous_variant	0.83[CHB]; 0.825[JPT]
rs1014969	upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs2071044	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant	0.866[CHB]; 0.822[JPT]; 0.867[GIH]; 0.828[LWK]; 0.826[MKK]; 0.946[YRI]
rs7624716	intron_variant	0.83[CHB]; 0.825[JPT]
rs2028216	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2286798	downstream_gene_variant; intron_variant; NMD_transcript_variant; upstream_gene_variant	0.91[CHB]; 0.872[CHD]; 0.908[JPT]
rs1866268	intron_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs33967311	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs3733041	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs4687550	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.862[CHB]; 0.865[JPT]
rs2289247	downstream_gene_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant	0.83[CHB]; 0.825[JPT]
rs9324	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant	0.82[TSI]; 0.859[CHB]; 0.848[CHD]; 0.865[JPT]; 0.831[MEX]
rs11130315	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2079929	intron_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs2710323	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.954[CHB]; 0.88[CHD]
rs11130312	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2336149	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs4687638	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs10865974	intron_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs3774355	downstream_gene_variant; intron_variant; upstream_gene_variant	0.862[CHB]; 0.825[JPT]
rs6778329	downstream_gene_variant; intron_variant; upstream_gene_variant	0.903[CHB]; 0.899[JPT]
rs1561337	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2336545	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs3755799	upstream_gene_variant	0.802[CHD]
rs2535627	downstream_gene_variant	0.826[CHB]; 0.825[JPT]; 0.891[GIH]
rs1042779	downstream_gene_variant; missense_variant; NMD_transcript_variant; upstream_gene_variant	0.81[CEU]; 1.0[CHB]; 0.923[CHD]; 0.865[JPT]
rs2083180	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2239551	downstream_gene_variant; intron_variant; upstream_gene_variant	0.859[CHB]; 0.847[CHD]; 0.865[JPT]
rs2072390	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.82[JPT]
rs2240919	downstream_gene_variant; intron_variant; upstream_gene_variant	0.91[CHB]; 0.861[JPT]
rs13085895	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs1075653	downstream_gene_variant; intron_variant; nc_transcript_variant; splice_region_variant; upstream_gene_variant	0.82[TSI]; 0.862[CHB]; 0.848[CHD]; 0.865[JPT]; 0.872[MEX]
rs2239549	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.819[CHB]; 0.848[CHD]; 0.865[JPT]
rs2071507	downstream_gene_variant; upstream_gene_variant	0.91[CHB]; 0.908[JPT]
rs12496634	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs8906	5_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs11130317	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs13068293	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2071506	downstream_gene_variant; upstream_gene_variant	0.822[TSI]; 0.817[CHB]; 0.848[CHD]; 0.865[JPT]; 0.872[MEX]
rs2071508	downstream_gene_variant; upstream_gene_variant	0.822[TSI]; 0.856[CHB]; 0.848[CHD]; 0.865[JPT]; 0.913[MEX]
rs3755806	nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs13083798	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.826[CHB]
rs2164885	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.822[CHB]; 0.862[JPT]
rs6617	5_prime_UTR_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs9881468	downstream_gene_variant; upstream_gene_variant	0.82[TSI]; 0.862[CHB]; 0.823[CHD]; 0.865[JPT]; 0.833[MEX]
rs12488461	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.811[JPT]
rs2268025	intron_variant	0.866[CHB]; 0.825[JPT]
rs2240920	downstream_gene_variant; intron_variant; upstream_gene_variant	0.803[CEU]; 0.866[TSI]; 0.91[CHB]; 0.872[CHD]; 0.908[JPT]; 0.913[MEX]
rs13064064	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs4687548	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs767418	downstream_gene_variant; intron_variant; upstream_gene_variant	0.83[CHB]; 0.817[JPT]
rs11130323	downstream_gene_variant; intron_variant	0.83[CHB]; 0.825[JPT]
rs13082208	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.856[CHB]; 0.946[JPT]
rs2268027	downstream_gene_variant; intron_variant; upstream_gene_variant	0.813[CHB]; 0.813[JPT]
rs3774365	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs12497998	downstream_gene_variant; intron_variant	0.83[CHB]; 0.825[JPT]
rs736408	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.904[CEU]; 0.954[CHB]; 0.953[JPT]; 0.944[YRI]
rs11717836	upstream_gene_variant	0.813[CHB]; 0.81[JPT]
rs1076425	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.822[TSI]; 0.862[CHB]; 0.848[CHD]; 0.865[JPT]; 0.831[MEX]
rs13082960	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.82[JPT]
rs6445534	downstream_gene_variant; upstream_gene_variant	0.83[CHB]
rs7611731	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs10510760	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs3755798	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.825[JPT]
rs12635140	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs3733045	intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant	0.83[CHB]; 0.825[JPT]
rs2239699	downstream_gene_variant; upstream_gene_variant	0.803[CEU]; 0.893[CHB]; 0.841[JPT]
rs2276824	intron_variant; nc_transcript_variant; NMD_transcript_variant	0.83[CHB]
rs13071584	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs7622694	intron_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs6976	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs2270197	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.862[CHB]; 0.865[JPT]
rs9879090	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.822[CHB]
rs13079063	downstream_gene_variant; upstream_gene_variant	0.821[CHB]; 0.861[JPT]
rs2159644	downstream_gene_variant; intron_variant	0.83[CHB]; 0.825[JPT]
rs2019065	upstream_gene_variant	1.0[CHB]; 0.948[CHD]; 0.908[JPT]
rs998909	upstream_gene_variant	0.823[CHB]; 0.857[JPT]
rs10865973	intron_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs2300149	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.862[CHB]; 0.848[CHD]; 0.865[JPT]
rs10780035	intron_variant; upstream_gene_variant	0.83[CHB]; 0.825[JPT]
rs34017441	downstream_gene_variant; upstream_gene_variant	0.83[CHB]; 0.865[JPT]
rs4481150	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.807[CHB]; 0.855[JPT]; 0.908[GIH]
rs4687551	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.844[TSI]; 0.862[CHB]; 0.848[CHD]; 0.825[JPT]; 0.872[MEX]
rs12487591	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant	0.83[CHB]; 0.825[JPT]
rs678	downstream_gene_variant; missense_variant; NMD_transcript_variant; upstream_gene_variant	0.91[CHB]; 0.908[JPT]