ADHDgene Database

SNP Report

Basic Info

Name	rs11727760 dbSNP Ensembl
Location	chr4:6352060(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000314348; ENST00000335585; ENST00000382599; ENST00000506140; ENST00000507294; ENST00000513943; ENST00000515571) nc_transcript_variant(ENST00000314348; ENST00000513943)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Jacob, C., 2012		A	P-value=0.8003, OR=1.0295% CI=(0.85-1.23) in the adult case-...... P-value=0.8003, OR=1.0295% CI=(0.85-1.23) in the adult case-control sample; FBAT P-value=0.0105 in the families with ADHD children More...	It reached nominal significance, however not surviving corre...... It reached nominal significance, however not surviving correction for multiple testing in the children sample. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	4p16.1	1(1/0/0)

SNPs in LD with rs11727760 (count: 4) View in gBrowse (chr4:6351958..6364311 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs11730177	intron_variant; nc_transcript_variant	0.926[ASW]; 0.828[MEX]
rs11727834	intron_variant; nc_transcript_variant	1.0[CEU]; 0.971[TSI]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 0.97[GIH]; 1.0[MEX]
rs4386675	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[TSI]; 1.0[ASW]; 1.0[CHB]; 0.946[CHD]; 0.951[JPT]; 0.97[GIH]; 0.852[LWK]; 0.915[MEX]; 0.938[MKK]; 0.907[YRI]
rs13124487	intron_variant; nc_transcript_variant	0.828[MEX]