Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa04722 |
|---|---|
| Name | Neurotrophin signaling pathway |
| Description | Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. |
| No. of Genes in ADHDgene | 24 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 24)
Literature-origin genes (count: 5)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| BDNF | brain-derived neurotrophic factor | 11p14.1 | 14(8/6/0) |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
| NTF3 | neurotrophin 3 | 12p13 | 3(1/2/0) |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 9q22.1 | 1(1/0/0) |
| NGF | nerve growth factor (beta polypeptide) | 1p13.1 | 2(2/0/0) |
Genes from other sources (count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RPS6KA4 | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 11q11-q13 | Mapped by significant region |
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 4q26 | Mapped by CNV |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 6q22.33 | Mapped by LD-proxy; Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 9q22.1 | Mapped by significant region |
| MAPK7 | mitogen-activated protein kinase 7 | 17p11.2 | Mapped by significant region |
| SH2B3 | SH2B adaptor protein 3 | 12q24.12 | Mapped by LD-proxy |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 2p25.2-p25.1 | Mapped by significant region |
| KIDINS220 | kinase D-interacting substrate, 220kDa | 2p24 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | 22q12.1-q13.1 | Mapped by PBA pathway |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 22q11.21 | Mapped by CNV |
| SORT1 | sortilin 1 | 1p13.3 | Mapped by CNV |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 16q24.1 | Mapped by significant region |