ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name DRD5_5'-flanking_(CT/GT/GA)n
Type microsatellite
Location 5' flanking, 18.5 kb from the 5' end of the gene DRD5
Related Gene DRD5
No. of Study 18 (significant: 13; non-significant 5; trend: 0)

Variant related studies (count: 18)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Li D, 2006 136-, 146-, 148-bp allele allele 136-bp: overall P(Z) P-value=0.0223, heterogeneity P(...... allele 136-bp: overall P(Z) P-value=0.0223, heterogeneity P(Q) P-value=0.6247, publication bias P(T) P-value=0.202, overall OR=0.57; allele 146-bp: overall P(Z) P-value=0.2252, heterogeneity P(Q) P-value=0.2118, publication bias P(T) P-value=0.593, overall OR=0.84; allele 148-bp: overall P(Z) P-value=8E-8, heterogeneity P(Q) P-value=0.0008, publication bias P(T) P-value=0.011, overall OR=1.34. More... allele 136-bp showed weak significant association; allele 14...... allele 136-bp showed weak significant association; allele 146-bp showed no significant association; allele 148-bp showed a significant association. More... Significant
Kirley A, 2002 148bp HHRR: P-value=0.000052 (RR=1.57, OR=2.52); TDT: P-value=0.00...... HHRR: P-value=0.000052 (RR=1.57, OR=2.52); TDT: P-value=0.0088 (OR=1.79); TDT by presence of family history: P-value=1 (OR[95%CI]=1.14[0.35-3.78]); TDT of Paternal and Maternal transmissions: P-value=0.62 (OR[95%CI]=1.24[0.53-2.92]) More... Significant preferential transmission Significant preferential transmission Significant
Payton A, 2001 156-132bp 148bp allelic TDT P-value=0.12 allelic TDT P-value=0.12 there was no evidence of preferential transmission of any ma...... there was no evidence of preferential transmission of any marker allele More... Non-significant
Barr CL, 2000 (c) 134-156bp TDT P-value=0.016 for allele 146 bp; TDT P-value=0.035 for a...... TDT P-value=0.016 for allele 146 bp; TDT P-value=0.035 for allele 136bp; TDT P-value=0.058 for allele 134bp; TDT P-value=0.281 for allele 148bp More... no observe significant evidence for the biased transmission ...... no observe significant evidence for the biased transmission of the 148-bp allele was observed. Significant evidence for biased transmission of two alleles, the 136-bp allele and the 146-bp allele, were observed. More... Significant
Maher BS, 2002 P-value=8.28E-5, pooled OR=1.57; test of homogeneity P-value...... P-value=8.28E-5, pooled OR=1.57; test of homogeneity P-value=0.28, Q=5.11, df=4 More... positive association was demostrated with ADHD in the meta-a...... positive association was demostrated with ADHD in the meta-analysis More... Significant
Bakker SC, 2005 9R allelic TDT P-value=0.32 allelic TDT P-value=0.32 no signs of a distorted transmissions of any of the single p...... no signs of a distorted transmissions of any of the single polymorphisms, or of single alleles More... Non-significant
Squassina A, 2008 136-152bp allele 136-bp: FBAT P-value=0.275, Z=1.09; allele 138-bp: FB...... allele 136-bp: FBAT P-value=0.275, Z=1.09; allele 138-bp: FBAT P-value=0.371, Z=0.89; allele 146-bp: FBAT P-value=0.201, Z=1.28; allele 148-bp: FBAT P-value=0.055, Z=1.91; allele 150-bp: FBAT P-value=0.023, Z=-2.26; allele 152-bp: FBAT P-value=0.028, Z=-2.20. More... non-significant trend of associations were found for allele ...... non-significant trend of associations were found for allele 136-, 138-, 146-, 148-bp, but allele 150-, 152-bp showed possible protective effect against ADHD. More... Significant
Kustanovich V, 2004 136, 146, 148-bp 148bp GRR=2.84, TDT P-value=0.178 for 136-bp allele; GRR=1.68, TDT...... GRR=2.84, TDT P-value=0.178 for 136-bp allele; GRR=1.68, TDT P-value=0.02 for 146-bp allele; GRR=1.35, TDT P-value=0.053 for 148-bp allele More... 136-bp allele is not significantly associated with ADHD; bia...... 136-bp allele is not significantly associated with ADHD; biased nontransmission of the 146-bp allele was found; trend toward excess transmission of the 148-bp allele was found. More... Significant
Manor I, 2004 148bp TDT P-value=0.008, RR=1.54, CI of RR = [1.11-2.12] TDT P-value=0.008, RR=1.54, CI of RR = [1.11-2.12] preferential transmission of the 148bp repeat was observed preferential transmission of the 148bp repeat was observed Significant
Johansson S, 2008 Overall P-value=0.04; allelic P-value=0.09, OR=1.20; overall...... Overall P-value=0.04; allelic P-value=0.09, OR=1.20; overall P-value=0.02, OR=1.27 in the inattentive or combined inattentive/hyperactive subtypes; overall P-value=0.04 for male patients More... nominally significant association nominally significant association Significant
Lowe N, 2004 (b) 148bp ETDT P-value=0.44, OR=1.5 in group 1; ETDT P-value=0.88, OR=...... ETDT P-value=0.44, OR=1.5 in group 1; ETDT P-value=0.88, OR=1.05 in group 2; ETDT P-value=0.29, OR=0.72 in group 3; ETDT P-value=1, OR=1 in group 4; ETDT P-value=0.77, OR=1.09 in group 5; ETDT P-value=0.21, OR=1.34 in group 6; ETDT P-value=0.28, OR=1.35 in group 7; ETDT P-value=0.42, OR=1.25 in group 8; ETDT P-value=0.05, OR=1.45 in group 9; ETDT P-value=0.02, OR=1.57 in group 10; ETDT P-value=0.004, OR=1.6 in group 11; ETDT P-value=0.38, OR=1.15 in group 12; ETDT P-value=0.75, OR=0.95 in group 13; ETDT P-value=0.05, OR=1.24 in group 14; ETDT P-value=0.00005, OR=1.24, X2=16.45, df=1 in the joint analysis. P-value=0.00007, OR=1.24 in sensitivity analysis for group 1; P-value=0.00004, OR=1.25 in sensitivity analysis for group 2; P-value=0.00002, OR=1.26 in sensitivity analysis for group 3; P-value=0.00004, OR=1.25 in sensitivity analysis for group 4; P-value=0.00007, OR=1.24 in sensitivity analysis for group 5; P-value=0.00011, OR=1.24 in sensitivity analysis for group 6; P-value=0.00009, OR=1.24 in sensitivity analysis for group 7; P-value=0.00007, OR=1.24 in sensitivity analysis for group 8; P-value=0.00027, OR=1.22 in sensitivity analysis for group 9; P-value=0.00041, OR=1.22 in sensitivity analysis for group 10; P-value=0.00103, OR=1.2 in sensitivity analysis for group 11; P-value=0.00007, OR=1.25 in sensitivity analysis for group 12; P-value=0.00001, OR=1.28 in sensitivity analysis for group 13; P-value=0.00039, OR=1.24 in sensitivity analysis for group 14; P-value=0.00005, OR=1.24 in joint analysis of all groups. P-value=0.257, X2=1.287 of predominantly inattentive vs. combined; P-value=0.103, X2=2.654 of predominantly hyperactive/impulsive vs. combined; P-value=0.035, X2=4.468 of predominantly inattentive vs. predominantly hyperactive/impulsive. More... TDT analyses on the individual samples tested showed a signi...... TDT analyses on the individual samples tested showed a significant association with two of the ADHD samples; a strongly significant association of small effect between ADHD and the 148-bp allele of the microsatellite marker was detected in the joint analysis; sensitivity analysis showed strong significance, regardless of the data set removed; comparison between the individual ORs indicated a significant difference between the inattentive and hyperactive/impulsive subtypes. More... Significant
Hawi Z, 2005 TDT P-value=0.0034, X2=9.1, OR=2 for paternel tra...... TDT P-value=0.0034, X2=9.1, OR=2 for paternel transmission; TDT P-value=0.07, X2=3.6, OR=1.5 for maternal transmission More... nominal significant overtransmission of paternal alleles was...... nominal significant overtransmission of paternal alleles was seen, no significant association was observed for maternal transmission More... Significant
Mill J, 2004 (a) 148bp TRANSMIT multi-locus P-value=0.63, single locus P-value=0.69...... TRANSMIT multi-locus P-value=0.63, single locus P-value=0.69 for allele 148bp More... no overall evidence for biased transmission no overall evidence for biased transmission Non-significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.23, 95% CI=1.06-1.43, P-va...... Meta-analysis model: Random: OR=1.23, 95% CI=1.06-1.43, P-value=0.0027; Q-statistic: P-value=0.063, I2=46 More... significant but modest association significant but modest association Significant
Tahir E, 2000 (b) 136-161bp 151bp TDT one-tailed P-value=0.061 TDT one-tailed P-value=0.061 trend evidence for DRD5*151 was found trend evidence for DRD5*151 was found Non-significant
Langley K, 2009 Case-control analysis: P-value=0.02, OR=1.62 (95%CI: 1.06-2....... Case-control analysis: P-value=0.02, OR=1.62 (95%CI: 1.06-2.47) for baseline ADHD; P-value=0.02, OR=1.75, (95%CI=1.11-2.77) for persistent ADHD More... significantly predicted baseline persistent ADHD diagnosis significantly predicted baseline persistent ADHD diagnosis Significant
Bobb AJ, 2005 allelic TDT P-value=0.91, OR=0.93 in case-control analysis; ...... allelic TDT P-value=0.91, OR=0.93 in case-control analysis; allelic TDT P-value=0.89 in family-based analysis More... non-significant association non-significant association Non-significant
Hawi Z, 2003 Global X2=0.009; HHRR P-value=0.73, X2...... Global X2=0.009; HHRR P-value=0.73, X2=0.11, RR=1.25 for allele3; HHRR P-value=1, X2=0.11, RR=1 for allele4; HHRR P-value=0.22, X2=1.46, RR=0.68 for allele5; HHRR P-value=0.00005, X2=16.36, RR=1.6 for allele6; HHRR P-value=0.48, X2=0.5, RR=1.38 for allele7; HHRR P-value=0.18, X2=1.75, RR=0.5 for allele8; HHRR P-value=0.36, X2=0.85, RR=0.57 for allele9; HHRR P-value=0.028, X2=4.78, RR=0.27 for allele10; HHRR P-value=0.14, X2=2.2, RR=0.6 for allele11; HHRR P-value=0.018, X2=5.6, RR=0.13 for allele12; HHRR P-value=0.35, X2=1.01, RR=0.33 for allele13 More... associations of 148 bp allele (allele 6 of the DRD5-PCR1) an...... associations of 148 bp allele (allele 6 of the DRD5-PCR1) and allele 12 to ADHD cases were reported More... Significant