ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004842
Name	ubiquitin-protein ligase activity
Type	molecular function
No. of Genes in ADHDgene	60
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 60)

Literature-origin genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FANCL	Fanconi anemia, complementation group L	2p16.1	1(0/1/0)	IDA[19111657]; ISS; TAS
PARK2	parkin RBR E3 ubiquitin protein ligase	6q25.2-q27	1(1/0/0)	IDA[16227987]
TRIM32	tripartite motif containing 32	9q33.1	1(0/0/1)	IDA[16816390]

Genes from other sources (count: 57)

Approved Symbol	Approved Name	Source	Evidence[PMID]
MARCH6	membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase	Mapped by significant region	IDA[15673284]; IMP[19651899]
RFWD3	ring finger and WD repeat domain 3	Mapped by significant region	IDA
RNF31	ring finger protein 31	Mapped by significant region	IDA[17006537]
KCTD13	potassium channel tetramerization domain containing 13	Mapped by CNV	IDA[19782033]
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region	IDA[15125833]
ZFP91	ZFP91 zinc finger protein	Mapped by significant region	IDA
RNF20	ring finger protein 20, E3 ubiquitin protein ligase	Mapped by significant region	IDA[19037095]; IDA[16307923]
BARD1	BRCA1 associated RING domain 1	Mapped by significant region	IDA; NAS[15905410]
ERCC8	excision repair cross-complementing rodent repair deficiency, complementation group 8	Mapped by CNV	IDA[12732143]
FBXL7	F-box and leucine-rich repeat protein 7	Mapped by significant region	NAS[10531035]
RNF151	ring finger protein 151	Mapped by significant region	IEA
HERC6	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	Mapped by CNV	IBA
CBL	Cbl proto-oncogene, E3 ubiquitin protein ligase	Mapped by significant region	TAS
MIB1	mindbomb E3 ubiquitin protein ligase 1	Mapped by significant region	IEA
UBE3A	ubiquitin protein ligase E3A	Mapped by CNV; Mapped by significant region	IDA[12890688]
FBXO25	F-box protein 25	Mapped by CNV	NAS[10531035]
PRPF19	pre-mRNA processing factor 19	Mapped by significant region	IDA[11435423]
TRIM13	tripartite motif containing 13	Mapped by LD-proxy	IDA[17314412]
RNF146	ring finger protein 146	Mapped by significant region	IDA
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	Mapped by CNV	IBA
ZNRF1	zinc and ring finger 1, E3 ubiquitin protein ligase	Mapped by significant region	ISS
BIRC3	baculoviral IAP repeat containing 3	Mapped by significant region	IDA[16395405]
KLHL20	kelch-like family member 20	Mapped by significant region	IDA
ANAPC4	anaphase promoting complex subunit 4	Mapped by CNV	TAS[6180011]
UBE2H	ubiquitin-conjugating enzyme E2H	Mapped by LD-proxy	IDA
UBE2I	ubiquitin-conjugating enzyme E2I	Mapped by significant region	TAS[19955185]
TRIM5	tripartite motif containing 5	Mapped by CNV	IDA
TNFAIP3	tumor necrosis factor, alpha-induced protein 3	Mapped by significant region	IDA[15258597]
RC3H1	ring finger and CCCH-type domains 1	Mapped by significant region	TAS[19217324]
MGRN1	mahogunin ring finger 1, E3 ubiquitin protein ligase	Mapped by significant region	IDA[19737927]
HERC5	HECT and RLD domain containing E3 ubiquitin protein ligase 5	Mapped by CNV	IBA
RNF2	ring finger protein 2	Mapped by significant region	IDA[16714294]
RNF40	ring finger protein 40, E3 ubiquitin protein ligase	Mapped by CNV	IDA[16307923]
UBE2L6	ubiquitin-conjugating enzyme E2L 6	Mapped by significant region	IEA
RCHY1	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	Mapped by CNV	IDA[19483087]
FBXO4	F-box protein 4	Mapped by significant region	IDA[10531035]
HECTD1	HECT domain containing E3 ubiquitin protein ligase 1	Mapped by significant region	IBA
RNF144B	ring finger protein 144B	Mapped by LD-proxy	IDA[12853982]
HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Mapped by significant region	IDA
NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	Mapped by significant region	IBA; NAS[11244092]
TRAF7	TNF receptor-associated factor 7, E3 ubiquitin protein ligase	Mapped by significant region	IDA[14743216]
BIRC2	baculoviral IAP repeat containing 2	Mapped by significant region	IDA[11907583]
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	Mapped by significant region	IDA[15466472]; IMP[19713937]; TAS
RNF25	ring finger protein 25	Mapped by significant region	ISS
BRAP	BRCA1 associated protein	Mapped by LD-proxy	IDA[14724641]
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	Mapped by significant region	IDA[15256501]
TRIP12	thyroid hormone receptor interactor 12	Mapped by PBA pathway	IBA; IDA[18627766]; IMP[19028681]; NAS
FBXW2	F-box and WD repeat domain containing 2	Mapped by significant region	TAS[10531035]
BIRC6	baculoviral IAP repeat containing 6	Mapped by CNV	IDA[15200957]
RNF125	ring finger protein 125, E3 ubiquitin protein ligase	Mapped by significant region	IEA
UBE2QL1	ubiquitin-conjugating enzyme E2Q family-like 1	Mapped by significant region	IEA
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	Mapped by significant region	IEA
RNF217	ring finger protein 217	Mapped by significant region	ISS
RNF130	ring finger protein 130	Mapped by CNV	IDA[16549277]
FBXO7	F-box protein 7	Mapped by LD-proxy	TAS[10531035]
MARCH4	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	Mapped by significant region	IDA[14722266]
SKP2	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	Mapped by significant region	IEA