ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0004842
Name ubiquitin-protein ligase activity
Type molecular function
No. of Genes in ADHDgene  60
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 60)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
FANCL Fanconi anemia, complementation group L 2p16.1 1(0/1/0) IDA[19111657]; ISS; TAS
PARK2 parkin RBR E3 ubiquitin protein ligase 6q25.2-q27 1(1/0/0) IDA[16227987]
TRIM32 tripartite motif containing 32 9q33.1 1(0/0/1) IDA[16816390]

Genes from other sources Help (count: 57)

Approved Symbol Approved Name Source Evidence[PMID]
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase Mapped by significant region IDA[15673284]; IMP[19651899]
RFWD3 ring finger and WD repeat domain 3 Mapped by significant region IDA
RNF31 ring finger protein 31 Mapped by significant region IDA[17006537]
KCTD13 potassium channel tetramerization domain containing 13 Mapped by CNV IDA[19782033]
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Mapped by significant region IDA[15125833]
ZFP91 ZFP91 zinc finger protein Mapped by significant region IDA
RNF20 ring finger protein 20, E3 ubiquitin protein ligase Mapped by significant region IDA[19037095]; IDA[16307923]
BARD1 BRCA1 associated RING domain 1 Mapped by significant region IDA; NAS[15905410]
ERCC8 excision repair cross-complementing rodent repair deficiency, complementation group 8 Mapped by CNV IDA[12732143]
FBXL7 F-box and leucine-rich repeat protein 7 Mapped by significant region NAS[10531035]
RNF151 ring finger protein 151 Mapped by significant region IEA
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Mapped by CNV IBA
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase Mapped by significant region TAS
MIB1 mindbomb E3 ubiquitin protein ligase 1 Mapped by significant region IEA
UBE3A ubiquitin protein ligase E3A Mapped by CNV; Mapped by significant region IDA[12890688]
FBXO25 F-box protein 25 Mapped by CNV NAS[10531035]
PRPF19 pre-mRNA processing factor 19 Mapped by significant region IDA[11435423]
TRIM13 tripartite motif containing 13 Mapped by LD-proxy IDA[17314412]
RNF146 ring finger protein 146 Mapped by significant region IDA
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 Mapped by CNV IBA
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase Mapped by significant region ISS
BIRC3 baculoviral IAP repeat containing 3 Mapped by significant region IDA[16395405]
KLHL20 kelch-like family member 20 Mapped by significant region IDA
ANAPC4 anaphase promoting complex subunit 4 Mapped by CNV TAS[6180011]
UBE2H ubiquitin-conjugating enzyme E2H Mapped by LD-proxy IDA
UBE2I ubiquitin-conjugating enzyme E2I Mapped by significant region TAS[19955185]
TRIM5 tripartite motif containing 5 Mapped by CNV IDA
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 Mapped by significant region IDA[15258597]
RC3H1 ring finger and CCCH-type domains 1 Mapped by significant region TAS[19217324]
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase Mapped by significant region IDA[19737927]
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 Mapped by CNV IBA
RNF2 ring finger protein 2 Mapped by significant region IDA[16714294]
RNF40 ring finger protein 40, E3 ubiquitin protein ligase Mapped by CNV IDA[16307923]
UBE2L6 ubiquitin-conjugating enzyme E2L 6 Mapped by significant region IEA
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase Mapped by CNV IDA[19483087]
FBXO4 F-box protein 4 Mapped by significant region IDA[10531035]
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 Mapped by significant region IBA
RNF144B ring finger protein 144B Mapped by LD-proxy IDA[12853982]
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 Mapped by significant region IDA
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase Mapped by significant region IBA; NAS[11244092]
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase Mapped by significant region IDA[14743216]
BIRC2 baculoviral IAP repeat containing 2 Mapped by significant region IDA[11907583]
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Mapped by significant region IDA[15466472]; IMP[19713937]; TAS
RNF25 ring finger protein 25 Mapped by significant region ISS
BRAP BRCA1 associated protein Mapped by LD-proxy IDA[14724641]
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 Mapped by significant region IDA[15256501]
TRIP12 thyroid hormone receptor interactor 12 Mapped by PBA pathway IBA; IDA[18627766]; IMP[19028681]; NAS
FBXW2 F-box and WD repeat domain containing 2 Mapped by significant region TAS[10531035]
BIRC6 baculoviral IAP repeat containing 6 Mapped by CNV IDA[15200957]
RNF125 ring finger protein 125, E3 ubiquitin protein ligase Mapped by significant region IEA
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 Mapped by significant region IEA
G2E3 G2/M-phase specific E3 ubiquitin protein ligase Mapped by significant region IEA
RNF217 ring finger protein 217 Mapped by significant region ISS
RNF130 ring finger protein 130 Mapped by CNV IDA[16549277]
FBXO7 F-box protein 7 Mapped by LD-proxy TAS[10531035]
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase Mapped by significant region IDA[14722266]
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase Mapped by significant region IEA