ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0031625
Name	ubiquitin protein ligase binding
Type	molecular function
No. of Genes in ADHDgene	30
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 30)

Literature-origin genes (count: 6)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FANCL	Fanconi anemia, complementation group L	2p16.1	1(0/1/0)	IPI[19111657]
ARRB2	arrestin, beta 2	17p13	1(1/0/0)	IPI[19372219]
PARK2	parkin RBR E3 ubiquitin protein ligase	6q25.2-q27	1(1/0/0)	IPI
ARRB1	arrestin, beta 1	11q13	2(1/1/0)	IPI[15878855]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IPI
MC4R	melanocortin 4 receptor	18q22	1(0/1/0)	IPI[19737927]

Genes from other sources (count: 24)

Approved Symbol	Approved Name	Source	Evidence[PMID]
AXIN1	axin 1	Mapped by significant region	IPI[16601693]
TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	Mapped by significant region	IDA[17636018]
CUL5	cullin 5	Mapped by significant region; Mapped by PBA pathway	IDA[17636018]
RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	Mapped by significant region	IPI[12748188]
RNF20	ring finger protein 20, E3 ubiquitin protein ligase	Mapped by significant region	IPI[16307923]
PDE4D	phosphodiesterase 4D, cAMP-specific	Mapped by CNV	IPI[19372219]
TRAF1	TNF receptor-associated factor 1	Mapped by significant region	IPI[11279055]
FZD4	frizzled class receptor 4	Mapped by significant region	IPI
UBXN1	UBX domain protein 1	Mapped by significant region	IDA[18775313]
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	Mapped by significant region	IPI[11279055]
USP2	ubiquitin specific peptidase 2	Mapped by significant region	IPI[17290220]
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Mapped by significant region	IPI
STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	Mapped by significant region	IEA
HERC2	HECT and RLD domain containing E3 ubiquitin protein ligase 2	Mapped by significant region	IPI
MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	Mapped by significant region	IPI[19737927]
ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	Mapped by significant region	IPI[18298843]
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	Mapped by significant region	IPI[15694336]
OTUB1	OTU deubiquitinase, ubiquitin aldehyde binding 1	Mapped by significant region	IPI
NKD2	naked cuticle homolog 2 (Drosophila)	Mapped by significant region	IPI[18757723]
RNF40	ring finger protein 40, E3 ubiquitin protein ligase	Mapped by CNV	IPI[16307923]
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	IPI[8666824]
MID1	midline 1 (Opitz/BBB syndrome)	Mapped by PBA pathway	IPI[17438131]
DAXX	death-domain associated protein	Mapped by PBA pathway	IPI[16845383]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV	IDA