ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0031625
Name ubiquitin protein ligase binding
Type molecular function
No. of Genes in ADHDgene  30
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 30)

Literature-origin genes (count: 6)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
FANCL Fanconi anemia, complementation group L 2p16.1 1(0/1/0) IPI[19111657]
ARRB2 arrestin, beta 2 17p13 1(1/0/0) IPI[19372219]
PARK2 parkin RBR E3 ubiquitin protein ligase 6q25.2-q27 1(1/0/0) IPI
ARRB1 arrestin, beta 1 11q13 2(1/1/0) IPI[15878855]
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IPI
MC4R melanocortin 4 receptor 18q22 1(0/1/0) IPI[19737927]

Genes from other sources Help (count: 24)

Approved Symbol Approved Name Source Evidence[PMID]
AXIN1 axin 1 Mapped by significant region IPI[16601693]
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B) Mapped by significant region IDA[17636018]
CUL5 cullin 5 Mapped by significant region; Mapped by PBA pathway IDA[17636018]
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IPI[12748188]
RNF20 ring finger protein 20, E3 ubiquitin protein ligase Mapped by significant region IPI[16307923]
PDE4D phosphodiesterase 4D, cAMP-specific Mapped by CNV IPI[19372219]
TRAF1 TNF receptor-associated factor 1 Mapped by significant region IPI[11279055]
FZD4 frizzled class receptor 4 Mapped by significant region IPI
UBXN1 UBX domain protein 1 Mapped by significant region IDA[18775313]
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) Mapped by significant region IPI[11279055]
USP2 ubiquitin specific peptidase 2 Mapped by significant region IPI[17290220]
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Mapped by significant region IPI
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase Mapped by significant region IEA
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 Mapped by significant region IPI
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Mapped by significant region IPI[19737927]
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c Mapped by significant region IPI[18298843]
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 Mapped by significant region IPI[15694336]
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 Mapped by significant region IPI
NKD2 naked cuticle homolog 2 (Drosophila) Mapped by significant region IPI[18757723]
RNF40 ring finger protein 40, E3 ubiquitin protein ligase Mapped by CNV IPI[16307923]
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Mapped by significant region IPI[8666824]
MID1 midline 1 (Opitz/BBB syndrome) Mapped by PBA pathway IPI[17438131]
DAXX death-domain associated protein Mapped by PBA pathway IPI[16845383]
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Mapped by CNV IDA