ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007264
Name small GTPase mediated signal transduction
Type biological process
No. of Genes in ADHDgene  65
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 65)

Literature-origin genes (count: 8)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) TAS
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1) TAS
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 12q13.13 1(0/0/1) TAS
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2p23.3 1(1/0/0) IEA
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) TAS
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) TAS
DOCK10 dedicator of cytokinesis 10 2q36.3 1(0/0/1) IEA
DIRAS2 DIRAS family, GTP-binding RAS-like 2 9q22.32 1(1/0/0) IEA

Genes from other sources Help (count: 57)

Approved Symbol Approved Name Source Evidence[PMID]
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 Mapped by significant region IEA
RAN RAN, member RAS oncogene family Mapped by PBA pathway IEA
RASD1 RAS, dexamethasone-induced 1 Mapped by significant region IEA
ARFIP2 ADP-ribosylation factor interacting protein 2 Mapped by CNV TAS[8670882]
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 Mapped by significant region TAS
CHN2 chimerin 2 Mapped by CNV TAS
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma Mapped by significant region TAS
RAB6C RAB6C, member RAS oncogene family Mapped by significant region TAS[10455022]
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 Mapped by CNV IEA
MCF2L MCF.2 cell line derived transforming sequence-like Mapped by CNV TAS
RASGEF1C RasGEF domain family, member 1C Mapped by CNV IEA
RHOT2 ras homolog family member T2 Mapped by significant region TAS
RAB2A RAB2A, member RAS oncogene family Mapped by PBA pathway IEA
ARHGAP18 Rho GTPase activating protein 18 Mapped by CNV; Mapped by significant region TAS
ARF6 ADP-ribosylation factor 6 Mapped by PBA pathway IEA
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Mapped by significant region TAS
RAB40C RAB40C, member RAS oncogene family Mapped by significant region IEA
PLD1 phospholipase D1, phosphatidylcholine-specific Mapped by PBA pathway TAS[8530346]
RAB1B RAB1B, member RAS oncogene family Mapped by significant region IEA
RAB27B RAB27B, member RAS oncogene family Mapped by Literature SNP IEA
IQGAP2 IQ motif containing GTPase activating protein 2 Mapped by CNV IEA
DOCK8 dedicator of cytokinesis 8 Mapped by CNV IEA
RAB30 RAB30, member RAS oncogene family Mapped by significant region IEA
DIRAS1 DIRAS family, GTP-binding RAS-like 1 Mapped by LD-proxy IEA
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 Mapped by significant region NAS[10486569]
RIT2 Ras-like without CAAX 2 Mapped by significant region NAS[8824319]; TAS
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Mapped by LD-proxy IEA
ARHGAP11B Rho GTPase activating protein 11B Mapped by CNV; Mapped by significant region TAS
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS
RAB14 RAB14, member RAS oncogene family Mapped by significant region; Mapped by PBA pathway NAS
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 Mapped by significant region IEA
RGL1 ral guanine nucleotide dissociation stimulator-like 1 Mapped by significant region NAS[10760592]
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Mapped by PBA pathway TAS
RAB27A RAB27A, member RAS oncogene family Mapped by LD-proxy IEA
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta Mapped by significant region IEA
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region TAS
RAB38 RAB38, member RAS oncogene family Mapped by significant region NAS[10910072]
ARL2 ADP-ribosylation factor-like 2 Mapped by significant region IEA
ARL17B ADP-ribosylation factor-like 17B Mapped by LD-proxy IEA
RAB26 RAB26, member RAS oncogene family Mapped by significant region IEA
RGL4 ral guanine nucleotide dissociation stimulator-like 4 Mapped by CNV IEA
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region TAS
ARHGAP32 Rho GTPase activating protein 32 Mapped by significant region TAS
PLD2 phospholipase D2 Mapped by PBA pathway TAS[9582313]
RAB39A RAB39A, member RAS oncogene family Mapped by significant region IEA
FAM13A family with sequence similarity 13, member A Mapped by CNV TAS
ARHGAP20 Rho GTPase activating protein 20 Mapped by significant region TAS
RAB6A RAB6A, member RAS oncogene family Mapped by CNV; Mapped by significant region IEA
ARHGAP11A Rho GTPase activating protein 11A Mapped by CNV; Mapped by significant region TAS
RASL11B RAS-like, family 11, member B Mapped by CNV IEA
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 Mapped by CNV TAS
RAB37 RAB37, member RAS oncogene family Mapped by CNV IEA
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region TAS
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
ARHGAP5 Rho GTPase activating protein 5 Mapped by significant region TAS
ARHGAP8 Rho GTPase activating protein 8 Mapped by CNV TAS
RHOD ras homolog family member D Mapped by significant region TAS