ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0003700
Name	sequence-specific DNA binding transcription factor activity
Type	Molecular Function
No. of Genes in ADHDgene	132
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 132)

Literature-origin genes (count: 15)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
MYT1L	myelin transcription factor 1-like	2p25.3	1(0/0/1)
LMO4	LIM domain only 4	1p22.3	1(0/1/0)	TAS[10209267]
FOXP2	forkhead box P2	7q31	1(1/0/0)	IDA[18987363]
HES6	hairy and enhancer of split 6 (Drosophila)	2q37.3	1(0/1/0)
CREB5	cAMP responsive element binding protein 5	7p15	1(0/0/1)	IDA[8378084]
NFIL3	nuclear factor, interleukin 3 regulated	9q22	2(1/1/0)	TAS[7565758]
DMRT2	doublesex and mab-3 related transcription factor 2	9p24.3	1(0/0/1)	TAS[10332030]
HOXB1	homeobox B1	17q21.32	1(0/0/1)
CLOCK	clock homolog (mouse)	4q12	2(2/0/0)
MEIS2	Meis homeobox 2	15q14	1(0/0/1)
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	12q23	2(2/0/0)
NR3C2	nuclear receptor subfamily 3, group C, member 2	4q31	1(0/1/0)
TFEB	transcription factor EB	6p21	1(0/0/1)	IDA[19556463]; NAS[2115126]
ISL1	ISL LIM homeobox 1	5q11.2	1(0/1/0)
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)	IDA[17681138]

Genes from other sources (count: 117)

Approved Symbol	Approved Name	Source	Evidence[PMID]
HEY2	hairy/enhancer-of-split related with YRPW motif 2	Mapped by significant region	IDA[15485867]
BARX2	BARX homeobox 2	Mapped by significant region
BATF2	basic leucine zipper transcription factor, ATF-like 2	Mapped by significant region
ZNF75CP	zinc finger protein 75C, pseudogene	Mapped by significant region
HOXA3	homeobox A3	Mapped by significant region
ZNF263	zinc finger protein 263	Mapped by LD-proxy
PHF1	PHD finger protein 1	Mapped by LD-proxy	TAS[9545646]
MTA2	metastasis associated 1 family, member 2	Mapped by significant region
BARX1	BARX homeobox 1	Mapped by significant region	NAS[10995576]
LMX1B	LIM homeobox transcription factor 1, beta	Mapped by significant region	IDA[10767331]
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	Mapped by significant region	IDA[11909962]
ZNF367	zinc finger protein 367	Mapped by significant region	IDA[15344908]
TADA2A	transcriptional adaptor 2A	Mapped by CNV	TAS[8552087]
TRIM29	tripartite motif containing 29	Mapped by significant region	TAS[8188213]
LHX1	LIM homeobox 1	Mapped by CNV
TSHZ2	teashirt zinc finger homeobox 2	Mapped by LD-proxy; Mapped by literature SNP
HNF1B	HNF1 homeobox B	Mapped by CNV	IDA[15509593]
TARDBP	TAR DNA binding protein	Mapped by literature SNP	TAS[7745706]
ZNF287	zinc finger protein 287	Mapped by significant region
PHF5A	PHD finger protein 5A	Mapped by PBA pathway
TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	Mapped by CNV	IDA[9603525]
HOXA5	homeobox A5	Mapped by significant region	IDA[10879542]
PKNOX2	PBX/knotted 1 homeobox 2	Mapped by significant region
TRIM22	tripartite motif containing 22	Mapped by CNV	TAS[7797467]
AATF	apoptosis antagonizing transcription factor	Mapped by CNV	IDA[10580117]
TCF25	transcription factor 25 (basic helix-loop-helix)	Mapped by significant region	IDA[16574069]
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region	IDA[16407292]
HOXA4	homeobox A4	Mapped by significant region
FLI1	Friend leukemia virus integration 1	Mapped by significant region
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region	IDA[9697705]
NFE2L3	nuclear factor (erythroid-derived 2)-like 3	Mapped by CNV; Mapped by significant region
PTTG1	pituitary tumor-transforming 1	Mapped by significant region	TAS[9811450]
HOXA9	homeobox A9	Mapped by significant region
E2F5	E2F transcription factor 5, p130-binding	Mapped by CNV
ZNF169	zinc finger protein 169	Mapped by significant region
RAX	retina and anterior neural fold homeobox	Mapped by LD-proxy; Mapped by significant region
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	Mapped by significant region	TAS[8608938]
HOXA7	homeobox A7	Mapped by significant region
CREBZF	CREB/ATF bZIP transcription factor	Mapped by significant region
NPAT	nuclear protein, ataxia-telangiectasia locus	Mapped by CNV; Mapped by significant region	IDA[18850719]
TBX1	T-box 1	Mapped by CNV	IDA[11111039]
E2F6	E2F transcription factor 6	Mapped by significant region
FOXD4	forkhead box D4	Mapped by CNV	TAS[9325056]
BSX	brain-specific homeobox	Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[12048232]
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Mapped by LD-proxy	IDA[12833137]
PHOX2A	paired-like homeobox 2a	Mapped by significant region
HOXA6	homeobox A6	Mapped by significant region
MTA3	metastasis associated 1 family, member 3	Mapped by LD-proxy; Mapped by literature SNP
ZNF24	zinc finger protein 24	Mapped by significant region
EBF1	early B-cell factor 1	Mapped by significant region
NPAS2	neuronal PAS domain protein 2	Mapped by CNV
ZNF215	zinc finger protein 215	Mapped by CNV	NAS[10762538]
LHX2	LIM homeobox 2	Mapped by significant region
ZNF70	zinc finger protein 70	Mapped by CNV
ZNF202	zinc finger protein 202	Mapped by significant region
RCOR2	REST corepressor 2	Mapped by significant region
PRDM1	PR domain containing 1, with ZNF domain	Mapped by CNV	TAS[1851123]
EVX1	even-skipped homeobox 1	Mapped by significant region
RORA	RAR-related orphan receptor A	Mapped by LD-proxy; Mapped by literature SNP	IDA[17545671]
GSC2	goosecoid homeobox 2	Mapped by CNV	IDA[9700206]
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region	IDA[9169153]
ZNF189	zinc finger protein 189	Mapped by significant region	TAS[9653648]
STRN3	striatin, calmodulin binding protein 3	Mapped by significant region	IDA[11570823]
IRF9	interferon regulatory factor 9	Mapped by significant region
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Mapped by significant region	NAS[10821850]
FOSL1	FOS-like antigen 1	Mapped by significant region
TBX6	T-box 6	Mapped by CNV
GTF2H3	general transcription factor IIH, polypeptide 3, 34kDa	Mapped by CNV
IKZF1	IKAROS family zinc finger 1 (Ikaros)	Mapped by LD-proxy
IRX3	iroquois homeobox 3	Mapped by CNV
HOXB3	homeobox B3	Mapped by LD-proxy
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Mapped by significant region	TAS[2030914]
TBX10	T-box 10	Mapped by significant region
CBFA2T3	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	Mapped by significant region
HOXA1	homeobox A1	Mapped by significant region
ZSCAN30	zinc finger and SCAN domain containing 30	Mapped by significant region
LHX6	LIM homeobox 6	Mapped by significant region	NAS[10393337]
NEUROD2	neurogenic differentiation 2	Mapped by LD-proxy	TAS[8816493]
TMEM229A	transmembrane protein 229A	Mapped by CNV
HIRA	HIR histone cell cycle regulation defective homolog A (S. cerevisiae)	Mapped by CNV	TAS[9731536]
HINFP	histone H4 transcription factor	Mapped by significant region	IMP[9540062]
FEV	FEV (ETS oncogene family)	Mapped by significant region
ZSCAN29	zinc finger and SCAN domain containing 29	Mapped by LD-proxy
PBX3	pre-B-cell leukemia homeobox 3	Mapped by significant region
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	Mapped by significant region
HOXA10	homeobox A10	Mapped by significant region
TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	Mapped by CNV	NAS[9695952]
GATA6	GATA binding protein 6	Mapped by significant region	IDA[19666519]
ZNF396	zinc finger protein 396	Mapped by significant region
LZTR1	leucine-zipper-like transcription regulator 1	Mapped by CNV	TAS[7633402]
HMGA1	high mobility group AT-hook 1	Mapped by PBA pathway	IMP[10428834]
KDM1A	lysine (K)-specific demethylase 1A	Mapped by LD-proxy
ZNF397	zinc finger protein 397	Mapped by significant region
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	Mapped by significant region	NAS[7801123]
HOXA11	homeobox A11	Mapped by significant region
FOXL1	forkhead box L1	Mapped by significant region
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	Mapped by significant region
NKX6-2	NK6 homeobox 2	Mapped by CNV	NAS[11210186]
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	Mapped by CNV	TAS[9874765]
KLF11	Kruppel-like factor 11	Mapped by significant region	TAS[9748269]
NCOR1	nuclear receptor corepressor 1	Mapped by significant region
RREB1	ras responsive element binding protein 1	Mapped by CNV
SP4	Sp4 transcription factor	Mapped by significant region
ZFP37	zinc finger protein 37 homolog (mouse)	Mapped by significant region	NAS[9585434]
VENTX	VENT homeobox	Mapped by CNV
ONECUT2	one cut homeobox 2	Mapped by significant region
HOXA13	homeobox A13	Mapped by significant region
SCAND3	SCAN domain containing 3	Mapped by LD-proxy
ATF6	activating transcription factor 6	Mapped by CNV
POU2F3	POU class 2 homeobox 3	Mapped by significant region
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region	NAS[9422764]
HSF2	heat shock transcription factor 2	Mapped by significant region
ZNF483	zinc finger protein 483	Mapped by significant region
TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	Mapped by significant region
SNAI3	snail homolog 3 (Drosophila)	Mapped by significant region
HOXA2	homeobox A2	Mapped by significant region