ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0004674
Name protein serine/threonine kinase activity
Type molecular function
No. of Genes in ADHDgene  65
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 65)

Literature-origin genes (count: 10)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
PRKD1 protein kinase D1 14q11 1(0/1/0) IDA[18440775]; TAS[8119958]
MAP2K3 mitogen-activated protein kinase kinase 3 17q11.2 1(0/1/0) IEA
BMPR1B bone morphogenetic protein receptor, type IB 4q23-q24 1(0/0/1) IDA[12065756]
TNNI3K TNNI3 interacting kinase 1p31.1 1(0/1/0) IEA
CSNK1E casein kinase 1, epsilon 22q13.1 2(1/1/0) TAS[7797465]
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IDA[11035810]; ISS
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) IEA
DCLK1 doublecortin-like kinase 1 13q13.3 1(1/0/0) IEA
DCLK2 doublecortin-like kinase 2 4q31.3 1(0/0/1) IEA
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) IEA

Genes from other sources Help (count: 55)

Approved Symbol Approved Name Source Evidence[PMID]
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region IDA[16574662]
ANKK1 ankyrin repeat and kinase domain containing 1 Mapped by Literature SNP; Mapped by significant region IEA
SIK3 SIK family kinase 3 Mapped by significant region IDA[14976552]
AATK apoptosis-associated tyrosine kinase Mapped by LD-proxy IEA
ULK2 unc-51 like autophagy activating kinase 2 Mapped by significant region IDA[18936157]
ERN2 endoplasmic reticulum to nucleus signaling 2 Mapped by significant region IDA[11175748]
NEK4 NIMA-related kinase 4 Mapped by LD-proxy IEA
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Mapped by CNV IEA
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV IEA
SQSTM1 sequestosome 1 Mapped by CNV NAS[8618896]
GAK cyclin G associated kinase Mapped by LD-proxy IEA
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Mapped by significant region IDA[16278681]; TAS
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region IDA[18625725]
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1 Mapped by significant region IEA
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase Mapped by significant region EXP; IDA[19417104]; NAS[11331269]
MAP3K11 mitogen-activated protein kinase kinase kinase 11 Mapped by significant region IDA[8195146]
STK32C serine/threonine kinase 32C Mapped by CNV IEA
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 Mapped by significant region IDA[9792677]; IMP[12773393]
MYLK4 myosin light chain kinase family, member 4 Mapped by CNV IEA
SGK1 serum/glucocorticoid regulated kinase 1 Mapped by significant region IEA
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy IDA[15850461]
LATS2 large tumor suppressor kinase 2 Mapped by significant region IDA[10871863]; TAS
WNK2 WNK lysine deficient protein kinase 2 Mapped by significant region ISS
STK11 serine/threonine kinase 11 Mapped by CNV IDA[19892943]; TAS
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) Mapped by significant region IDA[15194684]; NAS[9341881]
MARK4 MAP/microtubule affinity-regulating kinase 4 Mapped by PBA pathway IDA[15009667]
ILK integrin-linked kinase Mapped by CNV IDA[9366252]
KNDC1 kinase non-catalytic C-lobe domain (KIND) containing 1 Mapped by CNV IEA
PHKG2 phosphorylase kinase, gamma 2 (testis) Mapped by CNV NAS; TAS[10487978]
STK33 serine/threonine kinase 33 Mapped by Literature SNP ISS
RIPK3 receptor-interacting serine-threonine kinase 3 Mapped by significant region TAS[10339433]
ALPK2 alpha-kinase 2 Mapped by significant region IEA
STK31 serine/threonine kinase 31 Mapped by CNV; Mapped by significant region IEA
PLK1 polo-like kinase 1 Mapped by significant region IDA[19468302]; IMP
STK36 serine/threonine kinase 36 Mapped by significant region NAS; TAS[10806483]
PDPK1 3-phosphoinositide dependent protein kinase-1 Mapped by significant region IDA[9368760]
TSSK4 testis-specific serine kinase 4 Mapped by significant region IDA[15964553]; ISS
NEK6 NIMA-related kinase 6 Mapped by significant region IDA
STK16 serine/threonine kinase 16 Mapped by significant region IEA
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 Mapped by significant region IDA[11784851]
ATM ataxia telangiectasia mutated Mapped by CNV; Mapped by significant region IDA[9733515]
TTK TTK protein kinase Mapped by PBA pathway IEA
SIK2 salt-inducible kinase 2 Mapped by significant region IDA[18348280]
AURKC aurora kinase C Mapped by LD-proxy IEA
LATS1 large tumor suppressor kinase 1 Mapped by PBA pathway IDA; TAS
MARK2 MAP/microtubule affinity-regulating kinase 2 Mapped by significant region IDA; NAS[8274451]
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 Mapped by significant region TAS[9878560]
TSSK2 testis-specific serine kinase 2 Mapped by CNV IDA[18533145]; ISS
RABEP2 rabaptin, RAB GTPase binding effector protein 2 Mapped by LD-proxy IEA
TAOK2 TAO kinase 2 Mapped by CNV IDA[11279118]
FASTK Fas-activated serine/threonine kinase Mapped by Literature SNP IDA[7544399]
SPEG SPEG complex locus Mapped by significant region IEA
CHEK1 checkpoint kinase 1 Mapped by significant region IDA[16963448]
RIOK3 RIO kinase 3 Mapped by significant region IEA
BCKDK branched chain ketoacid dehydrogenase kinase Mapped by CNV ISS