ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0004674
Name	protein serine/threonine kinase activity
Type	molecular function
No. of Genes in ADHDgene	65
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 65)

Literature-origin genes (count: 10)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
PRKD1	protein kinase D1	14q11	1(0/1/0)	IDA[18440775]; TAS[8119958]
MAP2K3	mitogen-activated protein kinase kinase 3	17q11.2	1(0/1/0)	IEA
BMPR1B	bone morphogenetic protein receptor, type IB	4q23-q24	1(0/0/1)	IDA[12065756]
TNNI3K	TNNI3 interacting kinase	1p31.1	1(0/1/0)	IEA
CSNK1E	casein kinase 1, epsilon	22q13.1	2(1/1/0)	TAS[7797465]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IDA[11035810]; ISS
TRIO	trio Rho guanine nucleotide exchange factor	5p14-p15.1	1(0/0/1)	IEA
DCLK1	doublecortin-like kinase 1	13q13.3	1(1/0/0)	IEA
DCLK2	doublecortin-like kinase 2	4q31.3	1(0/0/1)	IEA
MAP2K5	mitogen-activated protein kinase kinase 5	15q22.31	1(1/0/0)	IEA

Genes from other sources (count: 55)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ROCK2	Rho-associated, coiled-coil containing protein kinase 2	Mapped by significant region	IDA[16574662]
ANKK1	ankyrin repeat and kinase domain containing 1	Mapped by Literature SNP; Mapped by significant region	IEA
SIK3	SIK family kinase 3	Mapped by significant region	IDA[14976552]
AATK	apoptosis-associated tyrosine kinase	Mapped by LD-proxy	IEA
ULK2	unc-51 like autophagy activating kinase 2	Mapped by significant region	IDA[18936157]
ERN2	endoplasmic reticulum to nucleus signaling 2	Mapped by significant region	IDA[11175748]
NEK4	NIMA-related kinase 4	Mapped by LD-proxy	IEA
PIK3CG	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Mapped by CNV	IEA
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	Mapped by CNV	IEA
SQSTM1	sequestosome 1	Mapped by CNV	NAS[8618896]
GAK	cyclin G associated kinase	Mapped by LD-proxy	IEA
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region	IDA[16278681]; TAS
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region	IDA[18625725]
PKMYT1	protein kinase, membrane associated tyrosine/threonine 1	Mapped by significant region	IEA
SMG1	SMG1 phosphatidylinositol 3-kinase-related kinase	Mapped by significant region	EXP; IDA[19417104]; NAS[11331269]
MAP3K11	mitogen-activated protein kinase kinase kinase 11	Mapped by significant region	IDA[8195146]
STK32C	serine/threonine kinase 32C	Mapped by CNV	IEA
RPS6KA4	ribosomal protein S6 kinase, 90kDa, polypeptide 4	Mapped by significant region	IDA[9792677]; IMP[12773393]
MYLK4	myosin light chain kinase family, member 4	Mapped by CNV	IEA
SGK1	serum/glucocorticoid regulated kinase 1	Mapped by significant region	IEA
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy	IDA[15850461]
LATS2	large tumor suppressor kinase 2	Mapped by significant region	IDA[10871863]; TAS
WNK2	WNK lysine deficient protein kinase 2	Mapped by significant region	ISS
STK11	serine/threonine kinase 11	Mapped by CNV	IDA[19892943]; TAS
CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	Mapped by significant region	IDA[15194684]; NAS[9341881]
MARK4	MAP/microtubule affinity-regulating kinase 4	Mapped by PBA pathway	IDA[15009667]
ILK	integrin-linked kinase	Mapped by CNV	IDA[9366252]
KNDC1	kinase non-catalytic C-lobe domain (KIND) containing 1	Mapped by CNV	IEA
PHKG2	phosphorylase kinase, gamma 2 (testis)	Mapped by CNV	NAS; TAS[10487978]
STK33	serine/threonine kinase 33	Mapped by Literature SNP	ISS
RIPK3	receptor-interacting serine-threonine kinase 3	Mapped by significant region	TAS[10339433]
ALPK2	alpha-kinase 2	Mapped by significant region	IEA
STK31	serine/threonine kinase 31	Mapped by CNV; Mapped by significant region	IEA
PLK1	polo-like kinase 1	Mapped by significant region	IDA[19468302]; IMP
STK36	serine/threonine kinase 36	Mapped by significant region	NAS; TAS[10806483]
PDPK1	3-phosphoinositide dependent protein kinase-1	Mapped by significant region	IDA[9368760]
TSSK4	testis-specific serine kinase 4	Mapped by significant region	IDA[15964553]; ISS
NEK6	NIMA-related kinase 6	Mapped by significant region	IDA
STK16	serine/threonine kinase 16	Mapped by significant region	IEA
MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2	Mapped by significant region	IDA[11784851]
ATM	ataxia telangiectasia mutated	Mapped by CNV; Mapped by significant region	IDA[9733515]
TTK	TTK protein kinase	Mapped by PBA pathway	IEA
SIK2	salt-inducible kinase 2	Mapped by significant region	IDA[18348280]
AURKC	aurora kinase C	Mapped by LD-proxy	IEA
LATS1	large tumor suppressor kinase 1	Mapped by PBA pathway	IDA; TAS
MARK2	MAP/microtubule affinity-regulating kinase 2	Mapped by significant region	IDA; NAS[8274451]
RPS6KB2	ribosomal protein S6 kinase, 70kDa, polypeptide 2	Mapped by significant region	TAS[9878560]
TSSK2	testis-specific serine kinase 2	Mapped by CNV	IDA[18533145]; ISS
RABEP2	rabaptin, RAB GTPase binding effector protein 2	Mapped by LD-proxy	IEA
TAOK2	TAO kinase 2	Mapped by CNV	IDA[11279118]
FASTK	Fas-activated serine/threonine kinase	Mapped by Literature SNP	IDA[7544399]
SPEG	SPEG complex locus	Mapped by significant region	IEA
CHEK1	checkpoint kinase 1	Mapped by significant region	IDA[16963448]
RIOK3	RIO kinase 3	Mapped by significant region	IEA
BCKDK	branched chain ketoacid dehydrogenase kinase	Mapped by CNV	ISS