ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0045944
Name positive regulation of transcription from RNA polymerase II promoter
Type biological process
No. of Genes in ADHDgene  141
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 141)

Literature-origin genes (count: 25)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
PRKD1 protein kinase D1 14q11 1(0/1/0) IMP[18059339]
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa 8q24 1(0/1/0) IMP[10409744]
CLOCK clock circadian regulator 4q12 2(2/0/0) IGI[9576906]
HES1 hes family bHLH transcription factor 1 3q28-q29 1(1/0/0) ISS
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IEA
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) ISS
LMO4 LIM domain only 4 1p22.3 1(0/1/0) IEA
NR4A2 nuclear receptor subfamily 4, group A, member 2 2q22-q23 2(0/2/0) IEA
MEIS2 Meis homeobox 2 15q14 1(0/0/1) IEA
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) IEA
ARRB1 arrestin, beta 1 11q13 2(1/1/0) IMP[16325578]
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0) IEA
HOXB1 homeobox B1 17q21.32 1(0/0/1) IEA
DRD3 dopamine receptor D3 3q13.3 8(1/7/0) IEA
ISL1 ISL LIM homeobox 1 5q11.2 1(0/1/0) ISS
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0) IEA
TFEB transcription factor EB 6p21 1(0/0/1) IDA[19556463]
FOXP1 forkhead box P1 3p14.1 1(0/0/1) IEA
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) IDA[12358785]
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) IDA[18093989]; IMP[18093989]
NTF3 neurotrophin 3 12p13 4(1/3/0) IEA
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IDA[12169688]
ATXN1 ataxin 1 6p23 1(0/0/1) IEA
CDH13 cadherin 13 16q23.3 4(1/2/1) IMP[16099944]
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 2p16.1 1(0/0/1) ISS[19616629]

Genes from other sources Help (count: 116)

Approved Symbol Approved Name Source Evidence[PMID]
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 Mapped by significant region ISS
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) Mapped by significant region IBA; ISS
FADD Fas (TNFRSF6)-associated via death domain Mapped by significant region IDA[16127453]
RBM14 RNA binding motif protein 14 Mapped by significant region IDA[15919756]
BSX brain-specific homeobox Mapped by significant region IEA
PRDM9 PR domain containing 9 Mapped by significant region IEA
ARID3C AT rich interactive domain 3C (BRIGHT-like) Mapped by LD-proxy IEA
KLF4 Kruppel-like factor 4 (gut) Mapped by significant region IGI; ISS
MAML2 mastermind-like 2 (Drosophila) Mapped by significant region IDA[12370315]
TLR9 toll-like receptor 9 Mapped by LD-proxy ISS
MAML1 mastermind-like 1 (Drosophila) Mapped by CNV IDA[16510869]
AATF apoptosis antagonizing transcription factor Mapped by CNV IDA[18049476]
NCK2 NCK adaptor protein 2 Mapped by PBA pathway IDA[10026169]
HOXA13 homeobox A13 Mapped by significant region IEA
UBC ubiquitin C Mapped by CNV TAS
IKZF1 IKAROS family zinc finger 1 (Ikaros) Mapped by LD-proxy IEA
FLCN folliculin Mapped by significant region IDA; IMP
MED10 mediator complex subunit 10 Mapped by significant region IEA
PHOX2A paired-like homeobox 2a Mapped by significant region IDA[16280598]; IMP[19573018]
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta Mapped by PBA pathway IDA[11854298]
MED12 mediator complex subunit 12 Mapped by PBA pathway IDA[12037571]
VGLL2 vestigial like 2 (Drosophila) Mapped by significant region IEA
TLR4 toll-like receptor 4 Mapped by significant region ISS
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Mapped by significant region IDA[19245366]
RORA RAR-related orphan receptor A Mapped by Literature SNP IDA[17545671]
HOXA1 homeobox A1 Mapped by significant region IEA
NCOA6 nuclear receptor coactivator 6 Mapped by PBA pathway IDA[11443112]
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Mapped by significant region IEA
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IDA[17324931]
KLF13 Kruppel-like factor 13 Mapped by CNV; Mapped by significant region IEA
IHH indian hedgehog Mapped by significant region IEA
BCL9L B-cell CLL/lymphoma 9-like Mapped by significant region IMP[19328798]
PKD1 polycystic kidney disease 1 (autosomal dominant) Mapped by significant region IDA[16311606]
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 Mapped by significant region IDA[15247905]
AHI1 Abelson helper integration site 1 Mapped by significant region ISS
MED14 mediator complex subunit 14 Mapped by PBA pathway IDA[12037571]
NR5A1 nuclear receptor subfamily 5, group A, member 1 Mapped by significant region IMP[17664281]
HSF2 heat shock transcription factor 2 Mapped by significant region IDA[10561509]
IRF7 interferon regulatory factor 7 Mapped by LD-proxy IDA[16127453]
TBX1 T-box 1 Mapped by CNV ISS
ESRRA estrogen-related receptor alpha Mapped by significant region ISS
SS18 synovial sarcoma translocation, chromosome 18 Mapped by significant region IDA[15919756]
MAVS mitochondrial antiviral signaling protein Mapped by CNV IDA[18818105]
PYGO1 pygopus family PHD finger 1 Mapped by Literature SNP IEA
UTF1 undifferentiated embryonic cell transcription factor 1 Mapped by CNV IDA[9748258]
SREBF1 sterol regulatory element binding transcription factor 1 Mapped by significant region IDA[12242332]
MED1 mediator complex subunit 1 Mapped by LD-proxy; Mapped by PBA pathway IDA[12037571]; IMP[17641689]
STRN3 striatin, calmodulin binding protein 3 Mapped by significant region IDA[11570823]
FOXE1 forkhead box E1 (thyroid transcription factor 2) Mapped by significant region IBA
UBB ubiquitin B Mapped by significant region TAS
NCOA7 nuclear receptor coactivator 7 Mapped by significant region IDA[11971969]
LRP5 low density lipoprotein receptor-related protein 5 Mapped by CNV; Mapped by significant region IDA[12857724]
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway ISS[15528384]
MED13 mediator complex subunit 13 Mapped by PBA pathway IDA[12037571]
DAB2IP DAB2 interacting protein Mapped by significant region IDA[15310755]
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV IMP
FOXG1 forkhead box G1 Mapped by significant region IBA
BARX2 BARX homeobox 2 Mapped by significant region IEA
THRAP3 thyroid hormone receptor associated protein 3 Mapped by PBA pathway IDA[12037571]
MKL2 MKL/myocardin-like 2 Mapped by significant region IDA[14565952]
SOX8 SRY (sex determining region Y)-box 8 Mapped by significant region IDA[10662550]
KDM1A lysine (K)-specific demethylase 1A Mapped by LD-proxy IDA
PRPF6 pre-mRNA processing factor 6 Mapped by PBA pathway IDA[16414017]
GLIS2 GLIS family zinc finger 2 Mapped by significant region ISS
KAT5 K(lysine) acetyltransferase 5 Mapped by significant region IEA
FGF4 fibroblast growth factor 4 Mapped by significant region IEA
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 Mapped by significant region IEA
HOXA7 homeobox A7 Mapped by significant region IEA
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Mapped by significant region IEA
CHP2 calcineurin-like EF-hand protein 2 Mapped by significant region IDA[18815128]
HOXA5 homeobox A5 Mapped by significant region IDA[10879542]
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region IGI
HOXA2 homeobox A2 Mapped by significant region IEA
CIITA class II, major histocompatibility complex, transactivator Mapped by significant region IDA; IMP[9171108]
FOXD4 forkhead box D4 Mapped by CNV IBA
RBPJ recombination signal binding protein for immunoglobulin kappa J region Mapped by CNV IMP[18663143]
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 Mapped by CNV IDA[11950834]
MTA2 metastasis associated 1 family, member 2 Mapped by significant region IEA
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 Mapped by significant region IMP
BCL9 B-cell CLL/lymphoma 9 Mapped by CNV IEA
SQSTM1 sequestosome 1 Mapped by CNV TAS[12857745]
MCF2L MCF.2 cell line derived transforming sequence-like Mapped by CNV IEA
MEN1 multiple endocrine neoplasia I Mapped by significant region TAS
WWOX WW domain containing oxidoreductase Mapped by significant region ISS
MURC muscle-related coiled-coil protein Mapped by significant region IEA
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IDA[17350185]; IMP
CDON cell adhesion associated, oncogene regulated Mapped by significant region IEA
NCK1 NCK adaptor protein 1 Mapped by PBA pathway IDA[10026169]
CD3D CD3d molecule, delta (CD3-TCR complex) Mapped by significant region IDA[2017177]
NRIP1 nuclear receptor interacting protein 1 Mapped by PBA pathway IDA[10364267]
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Mapped by significant region IEA
HNF1B HNF1 homeobox B Mapped by CNV IEA
SPI1 spleen focus forming virus (SFFV) proviral integration oncogene Mapped by LD-proxy ISS
POU2F3 POU class 2 homeobox 3 Mapped by significant region IEA
FOXF1 forkhead box F1 Mapped by significant region IEA
TP53BP1 tumor protein p53 binding protein 1 Mapped by Literature SNP IMP[17805299]
LHX2 LIM homeobox 2 Mapped by significant region IEA
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 Mapped by significant region IEA
GATA6 GATA binding protein 6 Mapped by significant region IDA[19497978]; IEA
GREM1 gremlin 1, DAN family BMP antagonist Mapped by CNV; Mapped by significant region ISS[9660951]
YAP1 Yes-associated protein 1 Mapped by significant region IEA
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 Mapped by significant region ISS
SNW1 SNW domain containing 1 Mapped by PBA pathway IDA[14985122]
KMT2A lysine (K)-specific methyltransferase 2A Mapped by significant region IDA
NPAS2 neuronal PAS domain protein 2 Mapped by CNV IGI[9576906]
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) Mapped by significant region ISS[18292087]
TCF21 transcription factor 21 Mapped by CNV; Mapped by significant region ISS
UBE3A ubiquitin protein ligase E3A Mapped by CNV; Mapped by significant region IEA
MYB v-myb avian myeloblastosis viral oncogene homolog Mapped by significant region IDA; IMP
EVX1 even-skipped homeobox 1 Mapped by significant region IEA
MED17 mediator complex subunit 17 Mapped by significant region; Mapped by PBA pathway IDA[12037571]
ZNF462 zinc finger protein 462 Mapped by significant region IEA
LPIN1 lipin 1 Mapped by significant region IEA
NPAS4 neuronal PAS domain protein 4 Mapped by significant region IEA
CRLF3 cytokine receptor-like factor 3 Mapped by CNV IDA[19427400]
ONECUT2 one cut homeobox 2 Mapped by significant region IEA