ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0043410
Name positive regulation of MAPK cascade
Type biological process
No. of Genes in ADHDgene  19
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 19)

Literature-origin genes (count: 6)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) IDA[12804770]
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 9q22.1 1(1/0/0) ISS
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) IDA
ADRB3 adrenoceptor beta 3 8p12 2(0/2/0) IDA[15123695]
ADRA1B adrenoceptor alpha 1B 5q33.3 2(1/1/0) IDA
ADRB2 adrenoceptor beta 2, surface 5q31-q32 2(1/1/0) IDA[15123695]

Genes from other sources Help (count: 13)

Approved Symbol Approved Name Source Evidence[PMID]
SORBS3 sorbin and SH3 domain containing 3 Mapped by PBA pathway IEA
CDH2 cadherin 2, type 1, N-cadherin (neuronal) Mapped by significant region IEA
TBX1 T-box 1 Mapped by CNV ISS
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Mapped by significant region ISS
CDON cell adhesion associated, oncogene regulated Mapped by significant region IEA
TRIM5 tripartite motif containing 5 Mapped by CNV IMP
ZNF622 zinc finger protein 622 Mapped by significant region IDA
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IDA[12419823]
FLT4 fms-related tyrosine kinase 4 Mapped by CNV IMP[19779139]
FGF9 fibroblast growth factor 9 Mapped by significant region IEA
INS insulin Mapped by Literature SNP IDA[11500939]
IGF2 insulin-like growth factor 2 (somatomedin A) Mapped by LD-proxy IDA[11500939]
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase Mapped by significant region IDA[15001576]