ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0070374
Name positive regulation of ERK1 and ERK2 cascade
Type biological process
No. of Genes in ADHDgene  23
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 23)

Literature-origin genes (count: 6)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
ARRB2 arrestin, beta 2 17p13 1(1/0/0) IDA[10644702]; IMP[12582207]
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) IDA[14975937]
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) ISS
OPRM1 opioid receptor, mu 1 6q24-q25 1(1/0/0) ISS
ARRB1 arrestin, beta 1 11q13 2(1/1/0) IDA[10644702]
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0) IEA

Genes from other sources Help (count: 17)

Approved Symbol Approved Name Source Evidence[PMID]
VEGFB vascular endothelial growth factor B Mapped by significant region IDA[18259607]
FGF4 fibroblast growth factor 4 Mapped by significant region IDA[17167778]
ARHGAP8 Rho GTPase activating protein 8 Mapped by CNV IDA
FGF19 fibroblast growth factor 19 Mapped by significant region IDA[17623664]
CCL19 chemokine (C-C motif) ligand 19 Mapped by LD-proxy IDA[15778365]
GAREM GRB2 associated, regulator of MAPK1 Mapped by significant region IMP[19509291]
FLT4 fms-related tyrosine kinase 4 Mapped by CNV IMP[11532940]
CTGF connective tissue growth factor Mapped by significant region IDA
C1QTNF3 C1q and tumor necrosis factor related protein 3 Mapped by significant region IEA
NOX4 NADPH oxidase 4 Mapped by significant region IEA
PYCARD PYD and CARD domain containing Mapped by CNV IMP
TLR4 toll-like receptor 4 Mapped by significant region IEA
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein Mapped by significant region IMP[11544529]
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV IMP[19664780]
EDNRA endothelin receptor type A Mapped by PBA pathway IEA
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mapped by CNV IDA[17045821]
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IEA