ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0043066
Name negative regulation of apoptotic process
Type biological process
No. of Genes in ADHDgene  85
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 85)

Literature-origin genes (count: 10)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) IMP[10066377]
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IDA[14744935]
MAP2K5 mitogen-activated protein kinase kinase 5 15q22.31 1(1/0/0) ISS
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0) IMP[10818098]
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) IEA
IL1RN interleukin 1 receptor antagonist 2q14.2 2(1/1/0) IEA
FAIM2 Fas apoptotic inhibitory molecule 2 12q13 1(0/1/0) NAS[10535980]
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6p12 1(1/0/0) IDA[17525748]; ISS
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) TAS[7830769]
TRIM32 tripartite motif containing 32 9q33.1 1(0/0/1) IDA[18632609]

Genes from other sources Help (count: 75)

Approved Symbol Approved Name Source Evidence[PMID]
TERT telomerase reverse transcriptase Mapped by significant region IMP[10449030]
MED1 mediator complex subunit 1 Mapped by LD-proxy; Mapped by PBA pathway ISS
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit Mapped by significant region ISS
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase Mapped by significant region IMP[18070883]
GSTP1 glutathione S-transferase pi 1 Mapped by significant region IDA[16636664]; TAS[16130169]
PRAMENP PRAME N-terminal-like, pseudogene Mapped by LD-proxy IEA
AHI1 Abelson helper integration site 1 Mapped by significant region ISS
YAP1 Yes-associated protein 1 Mapped by significant region IEA
DPEP1 dipeptidase 1 (renal) Mapped by significant region IMP
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region IMP[18625725]
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mapped by CNV IDA[17045821]
AATF apoptosis antagonizing transcription factor Mapped by CNV IMP[15207272]
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV TAS[7954800]
CLCF1 cardiotrophin-like cytokine factor 1 Mapped by significant region TAS[14632778]
CXCL12 chemokine (C-X-C motif) ligand 12 Mapped by PBA pathway IDA
BIRC2 baculoviral IAP repeat containing 2 Mapped by significant region IDA; TAS
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV IEA
APC adenomatous polyposis coli Mapped by LD-proxy; Mapped by PBA pathway IEA
SYVN1 synovial apoptosis inhibitor 1, synoviolin Mapped by significant region IEA
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Mapped by significant region IMP[12665508]; TAS[16130169]
PLK1 polo-like kinase 1 Mapped by significant region IMP[18174154]
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 Mapped by significant region TAS[10074428]
F7 coagulation factor VII (serum prothrombin conversion accelerator) Mapped by CNV TAS[18612547]
BTC betacellulin Mapped by CNV IEA
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 Mapped by significant region IDA[10411904]
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Mapped by significant region IEA
VEGFB vascular endothelial growth factor B Mapped by significant region IDA[18259607]
AAMDC adipogenesis associated, Mth938 domain containing Mapped by significant region IEA
ATG5 autophagy related 5 Mapped by CNV IEA
PRLR prolactin receptor Mapped by significant region NAS[10585417]
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) Mapped by significant region IDA[15734730]
SORT1 sortilin 1 Mapped by CNV IDA[14985763]
AVEN apoptosis, caspase activation inhibitor Mapped by CNV IDA[10949025]
PRDX5 peroxiredoxin 5 Mapped by significant region IMP[18262354]
BIRC3 baculoviral IAP repeat containing 3 Mapped by significant region TAS[8552191]
API5 apoptosis inhibitor 5 Mapped by PBA pathway IMP[11075807]; ISS[9307294]; NAS[10780674]
CFDP1 craniofacial development protein 1 Mapped by significant region IEA
CRYAB crystallin, alpha B Mapped by significant region IDA[14752512]
FGF4 fibroblast growth factor 4 Mapped by significant region IEA
G2E3 G2/M-phase specific E3 ubiquitin protein ligase Mapped by significant region IEA
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) Mapped by significant region IEA
PDCD10 programmed cell death 10 Mapped by CNV IDA[17360971]
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) Mapped by significant region IEA
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) Mapped by significant region IEA
VNN1 vanin 1 Mapped by significant region ISS[15282320]
KLHL20 kelch-like family member 20 Mapped by significant region IMP
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Mapped by PBA pathway ISS
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Mapped by CNV IEA
EDNRA endothelin receptor type A Mapped by PBA pathway IEA
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 Mapped by significant region IDA[12167698]; NAS
ATM ataxia telangiectasia mutated Mapped by CNV; Mapped by significant region IEA
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IDA[7595060]; IMP[18719127]
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) Mapped by CNV; Mapped by significant region IEA
WNT11 wingless-type MMTV integration site family, member 11 Mapped by significant region IMP
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region IC; IGI
BFAR bifunctional apoptosis regulator Mapped by significant region IDA[10716992]
MIEN1 migration and invasion enhancer 1 Mapped by LD-proxy IDA
GATA6 GATA binding protein 6 Mapped by significant region IMP
SYNGAP1 synaptic Ras GTPase activating protein 1 Mapped by Literature SNP IEA
HNF1B HNF1 homeobox B Mapped by CNV IEA
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IDA[10747850]; IMP
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 Mapped by significant region IEA
CFL1 cofilin 1 (non-muscle) Mapped by significant region TAS[16130169]
KRT18 keratin 18 Mapped by PBA pathway IDA[11684708]
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mapped by significant region TAS[8876214]
BIRC6 baculoviral IAP repeat containing 6 Mapped by CNV IMP[15200957]; TAS[10544019]
PALB2 partner and localizer of BRCA2 Mapped by significant region IEA
BARD1 BRCA1 associated RING domain 1 Mapped by significant region IMP[15265711]
FLT4 fms-related tyrosine kinase 4 Mapped by CNV IMP[11532940]
KDM1A lysine (K)-specific demethylase 1A Mapped by LD-proxy IMP[17805299]
SOX8 SRY (sex determining region Y)-box 8 Mapped by significant region ISS
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Mapped by significant region NAS[11090634]
BDKRB2 bradykinin receptor B2 Mapped by PBA pathway IEA
INS insulin Mapped by Literature SNP NAS[16604263]
NUP62 nucleoporin 62kDa Mapped by PBA pathway IDA[11755531]; ISS