ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005615
Name extracellular space
Type cellular component
No. of Genes in ADHDgene  133
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 133)

Literature-origin genes (count: 20)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
GPC6 glypican 6 13q32 1(0/0/1) IEA
FURIN furin (paired basic amino acid cleaving enzyme) 15q26.1 1(0/0/1) IDA[10567353]
BCHE butyrylcholinesterase 3q26.1-q26.2 1(1/0/0) IBA
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 4q32.3 1(1/0/0) IDA[11751414]
IL16 interleukin 16 15q26.3 1(0/0/1) IEA
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1) TAS[1497627]
NPPC natriuretic peptide C 2q37.1 1(0/1/0) IEA
FGF12 fibroblast growth factor 12 3q28 1(0/1/0) TAS[10049777]
EREG epiregulin 4q21.21 1(0/0/1) IDA[14581411]
CDH13 cadherin 13 16q23.3 4(1/2/1) IDA[16873731]
SLIT1 slit homolog 1 (Drosophila) 10q23.3-q24 1(0/0/1) NAS[9813312]
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0) IDA[9202027]; ISS
NUCB1 nucleobindin 1 19q13.33 1(0/0/1) TAS[1520323]
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) IEA
GPC5 glypican 5 13q32 1(0/0/1) IEA
CMTM8 CKLF-like MARVEL transmembrane domain containing 8 3p22.2 1(1/0/0) IEA
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0) IDA[16597614]
IL1RN interleukin 1 receptor antagonist 2q14.2 2(1/1/0) IDA[12483741]
LPL lipoprotein lipase 8p22 1(0/0/1) IDA[12573449]
CNTF ciliary neurotrophic factor 11q12 1(1/0/0) IC[12643274]

Genes from other sources Help (count: 113)

Approved Symbol Approved Name Source Evidence[PMID]
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 Mapped by significant region IEA
JAM3 junctional adhesion molecule 3 Mapped by significant region IDA
WNT11 wingless-type MMTV integration site family, member 11 Mapped by significant region IBA
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway IDA[7060561]
IL5RA interleukin 5 receptor, alpha Mapped by CNV TAS[1495999]
GHR growth hormone receptor Mapped by CNV; Mapped by significant region IDA[9360546]; IMP[2825030]
PNLIPRP2 pancreatic lipase-related protein 2 Mapped by PBA pathway IDA[18702514]
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 Mapped by significant region IDA[17166734]
SORD sorbitol dehydrogenase Mapped by CNV TAS[6177277]
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) Mapped by PBA pathway IDA[17069818]
CTRB2 chymotrypsinogen B2 Mapped by significant region IEA
C1QTNF3 C1q and tumor necrosis factor related protein 3 Mapped by significant region ISS
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Mapped by significant region IBA
MEP1B meprin A, beta Mapped by significant region TAS[9288916]
FGF9 fibroblast growth factor 9 Mapped by significant region IDA[8321227]
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) Mapped by significant region TAS[3360803]
IL18 interleukin 18 (interferon-gamma-inducing factor) Mapped by significant region IEA
IL22RA2 interleukin 22 receptor, alpha 2 Mapped by significant region NAS[11390453]
METRN meteorin, glial cell differentiation regulator Mapped by significant region IEA
IL18BP interleukin 18 binding protein Mapped by significant region IEA
CTF1 cardiotrophin 1 Mapped by CNV IEA
UMOD uromodulin Mapped by significant region IEA
HPX hemopexin Mapped by CNV IDA[19433579]
ORM2 orosomucoid 2 Mapped by significant region IEA
IGFALS insulin-like growth factor binding protein, acid labile subunit Mapped by significant region IEA
ARG1 arginase 1 Mapped by significant region IEA
DPEP1 dipeptidase 1 (renal) Mapped by significant region ISS
F7 coagulation factor VII (serum prothrombin conversion accelerator) Mapped by CNV IEA
CBLN3 cerebellin 3 precursor Mapped by significant region IEA
CTSG cathepsin G Mapped by significant region IDA
PLA2G3 phospholipase A2, group III Mapped by PBA pathway TAS[10713052]
SPN sialophorin Mapped by CNV IDA[10899905]
WNT6 wingless-type MMTV integration site family, member 6 Mapped by significant region IBA
ORM1 orosomucoid 1 Mapped by significant region IEA
ATRN attractin Mapped by CNV IDA[17261078]
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 Mapped by significant region IDA[1695900]
SCGB1D1 secretoglobin, family 1D, member 1 Mapped by significant region TAS[10066439]
IHH indian hedgehog Mapped by significant region IEA
CCL28 chemokine (C-C motif) ligand 28 Mapped by significant region IEA
APOL4 apolipoprotein L, 4 Mapped by CNV ISS
SOD3 superoxide dismutase 3, extracellular Mapped by CNV IDA
PAPPA pregnancy-associated plasma protein A, pappalysin 1 Mapped by significant region IEA
CTRB1 chymotrypsinogen B1 Mapped by significant region IEA
PNLIPRP1 pancreatic lipase-related protein 1 Mapped by PBA pathway IDA[19824014]
ANGPTL5 angiopoietin-like 5 Mapped by significant region IEA
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mapped by significant region ISS
PRSS33 protease, serine, 33 Mapped by significant region IEA
TPSAB1 tryptase alpha/beta 1 Mapped by significant region IDA
IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) Mapped by significant region TAS[1673147]
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Mapped by significant region IEA
MSLN mesothelin Mapped by significant region IEA
LIPG lipase, endothelial Mapped by PBA pathway IDA[10192396]
ACHE acetylcholinesterase (Yt blood group) Mapped by PBA pathway IBA
GSN gelsolin Mapped by significant region; Mapped by PBA pathway IEA
TTR transthyretin Mapped by significant region IEA
PATE2 prostate and testis expressed 2 Mapped by significant region IDA[18387948]
GFRA4 GDNF family receptor alpha 4 Mapped by CNV IEA
GIF gastric intrinsic factor (vitamin B synthesis) Mapped by significant region IDA[14695536]
TNC tenascin C Mapped by significant region IDA
TNN tenascin N Mapped by significant region IEA
ANGPTL2 angiopoietin-like 2 Mapped by significant region IEA
CCL19 chemokine (C-C motif) ligand 19 Mapped by LD-proxy IEA
SCGB1D2 secretoglobin, family 1D, member 2 Mapped by significant region TAS[10066439]
GRP gastrin-releasing peptide Mapped by significant region IDA[8756537]
REG3A regenerating islet-derived 3 alpha Mapped by CNV TAS[8997243]
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 Mapped by significant region IEA
CTGF connective tissue growth factor Mapped by significant region IEA
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mapped by significant region IDA[11159191]
APOC3 apolipoprotein C-III Mapped by significant region IDA[11060345]
PRSS8 protease, serine, 8 Mapped by CNV IEA
APOA4 apolipoprotein A-IV Mapped by significant region IDA
WFDC1 WAP four-disulfide core domain 1 Mapped by CNV; Mapped by significant region NAS[10967136]
IL17C interleukin 17C Mapped by significant region IEA
PCSK6 proprotein convertase subtilisin/kexin type 6 Mapped by CNV IDA[8906861]
BTC betacellulin Mapped by CNV IEA
IL17D interleukin 17D Mapped by significant region IEA
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mapped by CNV IEA
SCGB3A1 secretoglobin, family 3A, member 1 Mapped by CNV IEA
IL32 interleukin 32 Mapped by significant region IEA
GREM1 gremlin 1, DAN family BMP antagonist Mapped by CNV; Mapped by significant region NAS[9660951]
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A Mapped by significant region IEA
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IDA[3023045]
C5 complement component 5 Mapped by significant region IEA
FN1 fibronectin 1 Mapped by significant region IDA
COL15A1 collagen, type XV, alpha 1 Mapped by significant region IDA
VNN3 vanin 3 Mapped by significant region IEA
APOC2 apolipoprotein C-II Mapped by PBA pathway IDA[10727238]
MMP20 matrix metallopeptidase 20 Mapped by significant region TAS[9398237]
NPY neuropeptide Y Mapped by CNV; Mapped by significant region ISS
CCL27 chemokine (C-C motif) ligand 27 Mapped by LD-proxy IEA
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal Mapped by CNV; Mapped by PBA pathway IEA
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18 Mapped by significant region IEA
MMP13 matrix metallopeptidase 13 (collagenase 3) Mapped by significant region TAS[8207000]
C1QTNF2 C1q and tumor necrosis factor related protein 2 Mapped by significant region IEA
RTN3 reticulon 3 Mapped by significant region TAS[10331947]
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) Mapped by significant region IDA[2164002]
MMP10 matrix metallopeptidase 10 (stromelysin 2) Mapped by significant region TAS[2844164]
C1QTNF4 C1q and tumor necrosis factor related protein 4 Mapped by LD-proxy IEA
IGFBP2 insulin-like growth factor binding protein 2, 36kDa Mapped by significant region IDA[15694994]
APOA5 apolipoprotein A-V Mapped by significant region IDA[19121291]
SEPP1 selenoprotein P, plasma, 1 Mapped by CNV; Mapped by significant region IEA
CXCL12 chemokine (C-X-C motif) ligand 12 Mapped by PBA pathway IEA
PATE4 prostate and testis expressed 4 Mapped by significant region IEA
OGN osteoglycin Mapped by significant region IDA
AMBP alpha-1-microglobulin/bikunin precursor Mapped by significant region IEA
FKTN fukutin Mapped by significant region TAS[9690476]
LAMC1 laminin, gamma 1 (formerly LAMB2) Mapped by significant region NAS[10964500]
APOA1 apolipoprotein A-I Mapped by significant region IDA[19433579]; ISS
INS insulin Mapped by Literature SNP IDA[9667398]
WNT10A wingless-type MMTV integration site family, member 10A Mapped by significant region IBA
IGF2 insulin-like growth factor 2 (somatomedin A) Mapped by LD-proxy IEA
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Mapped by CNV TAS[9515811]
VEGFB vascular endothelial growth factor B Mapped by significant region IDA[8637916]