ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007411
Name axon guidance
Type biological process
No. of Genes in ADHDgene  71
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 71)

Literature-origin genes (count: 17)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
UNC5B unc-5 homolog B (C. elegans) 10q22.2 1(0/0/1) TAS
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 3(0/3/0) TAS
NRXN1 neurexin 1 2p16.3 1(0/1/0) TAS[1621094]
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) TAS
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) TAS
NCAN neurocan 19p12 1(0/1/0) TAS
NRXN3 neurexin 3 14q31 1(0/1/0) TAS[1621094]
CLASP2 cytoplasmic linker associated protein 2 3p24.3 1(0/0/1) TAS
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 10p12 1(1/0/0) TAS
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 2(0/2/0) IEA
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 12q13.13 1(0/0/1) TAS
BDNF brain-derived neurotrophic factor 11p14.1 16(8/8/0) IEA
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) TAS
NTF3 neurotrophin 3 12p13 4(1/3/0) IEA
CNTN4 contactin 4 3p26.3 1(1/0/0) TAS[15106122]
ITGA1 integrin, alpha 1 5q11.1 2(0/2/0) TAS
SLIT1 slit homolog 1 (Drosophila) 10q23.3-q24 1(0/0/1) IDA[11748139]; TAS

Genes from other sources Help (count: 54)

Approved Symbol Approved Name Source Evidence[PMID]
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Mapped by CNV TAS
CFL1 cofilin 1 (non-muscle) Mapped by significant region TAS
WASL Wiskott-Aldrich syndrome-like Mapped by CNV TAS
CNTN6 contactin 6 Mapped by CNV TAS
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway TAS
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region TAS
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) Mapped by CNV IEA
CACNB1 calcium channel, voltage-dependent, beta 1 subunit Mapped by PBA pathway TAS
LHX2 LIM homeobox 2 Mapped by significant region IEA
MYH11 myosin, heavy chain 11, smooth muscle Mapped by CNV; Mapped by significant region TAS
CACNB3 calcium channel, voltage-dependent, beta 3 subunit Mapped by PBA pathway TAS
SPTBN2 spectrin, beta, non-erythrocytic 2 Mapped by significant region TAS
NFASC neurofascin Mapped by Literature SNP TAS
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) Mapped by significant region TAS[9096408]
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) Mapped by LD-proxy TAS
FES feline sarcoma oncogene Mapped by LD-proxy TAS
NCK2 NCK adaptor protein 2 Mapped by PBA pathway TAS
CACNB4 calcium channel, voltage-dependent, beta 4 subunit Mapped by PBA pathway TAS
STIP1 stress-induced phosphoprotein 1 Mapped by significant region TAS
NTN3 netrin 3 Mapped by significant region NAS[9143507]
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mapped by significant region TAS
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Mapped by Literature SNP; Mapped by PBA pathway TAS
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Mapped by significant region; Mapped by PBA pathway TAS
NCAM1 neural cell adhesion molecule 1 Mapped by significant region TAS
SCN3B sodium channel, voltage-gated, type III, beta subunit Mapped by significant region TAS
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway TAS
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 Mapped by significant region IEA
PLA2G10 phospholipase A2, group X Mapped by significant region; Mapped by PBA pathway IDA[15927955]
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit Mapped by CNV TAS
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 Mapped by significant region TAS
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway TAS
LAMA2 laminin, alpha 2 Mapped by CNV; Mapped by significant region IEA
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Mapped by significant region TAS
DPYSL4 dihydropyrimidinase-like 4 Mapped by CNV TAS
EPHA5 EPH receptor A5 Mapped by CNV; Mapped by significant region ISS
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) Mapped by significant region NAS[15105459]; TAS
TRPC4 transient receptor potential cation channel, subfamily C, member 4 Mapped by PBA pathway TAS
TRPC6 transient receptor potential cation channel, subfamily C, member 6 Mapped by significant region TAS
MYO10 myosin X Mapped by significant region TAS
ERBB2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 Mapped by LD-proxy TAS
NCK1 NCK adaptor protein 1 Mapped by PBA pathway TAS
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway TAS
TNR tenascin R Mapped by significant region NAS[8940128]
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A Mapped by significant region TAS
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit Mapped by PBA pathway TAS
CDH4 cadherin 4, type 1, R-cadherin (retinal) Mapped by CNV IEA
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Mapped by PBA pathway TAS
LAMC1 laminin, gamma 1 (formerly LAMB2) Mapped by significant region TAS
CHL1 cell adhesion molecule L1-like Mapped by CNV TAS
TUBB3 tubulin, beta 3 class III Mapped by significant region IMP
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region TAS
CLASP1 cytoplasmic linker associated protein 1 Mapped by PBA pathway TAS