ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0006915
Name apoptotic process
Type biological process
No. of Genes in ADHDgene  127
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 127)

Literature-origin genes (count: 13)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) TAS
ADRB1 adrenoceptor beta 1 10q25.3 2(0/2/0) IEA
KANK2 KN motif and ankyrin repeat domains 2 19p13.2 1(0/1/0) IEA
PRKD1 protein kinase D1 14q11 1(0/1/0) IEA
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) TAS
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1) TAS
UNC5B unc-5 homolog B (C. elegans) 10q22.2 1(0/0/1) TAS
FAIM2 Fas apoptotic inhibitory molecule 2 12q13 1(0/1/0) IEA
PHLDA1 pleckstrin homology-like domain, family A, member 1 12q15 1(0/1/0) IEA
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) TAS
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 11p11.2 1(0/0/1) TAS
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) TAS[10671514]
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 2p23 1(1/0/0) IEA

Genes from other sources Help (count: 114)

Approved Symbol Approved Name Source Evidence[PMID]
CASP5 caspase 5, apoptosis-related cysteine peptidase Mapped by significant region IEA
C22orf29 chromosome 22 open reading frame 29 Mapped by CNV IEA
CLPTM1L CLPTM1-like Mapped by significant region IEA
DFNA5 deafness, autosomal dominant 5 Mapped by CNV; Mapped by significant region IDA
NME3 NME/NM23 nucleoside diphosphate kinase 3 Mapped by significant region IEA
WWOX WW domain containing oxidoreductase Mapped by significant region IEA
BIRC2 baculoviral IAP repeat containing 2 Mapped by significant region TAS
AATF apoptosis antagonizing transcription factor Mapped by CNV TAS
UBC ubiquitin C Mapped by CNV TAS
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV IEA
RHOT2 ras homolog family member T2 Mapped by significant region IMP[12482879]
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Mapped by significant region IEA
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Mapped by significant region TAS
SPATA4 spermatogenesis associated 4 Mapped by LD-proxy IEP[12019456]
TMEM219 transmembrane protein 219 Mapped by CNV IEA
SGK1 serum/glucocorticoid regulated kinase 1 Mapped by significant region IEA
GREM1 gremlin 1, DAN family BMP antagonist Mapped by CNV; Mapped by significant region IEA
CYCS cytochrome c, somatic Mapped by CNV; Mapped by significant region IDA[8689682]; TAS
AVEN apoptosis, caspase activation inhibitor Mapped by CNV IEA
POLR2G polymerase (RNA) II (DNA directed) polypeptide G Mapped by significant region IEA
BIRC3 baculoviral IAP repeat containing 3 Mapped by significant region IEA
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region TAS
GADD45G growth arrest and DNA-damage-inducible, gamma Mapped by significant region IEA
SQSTM1 sequestosome 1 Mapped by CNV TAS
MCF2L MCF.2 cell line derived transforming sequence-like Mapped by CNV TAS
TJP1 tight junction protein 1 Mapped by CNV; Mapped by significant region TAS
KRT18 keratin 18 Mapped by PBA pathway IEA
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) Mapped by CNV IEA
AATK apoptosis-associated tyrosine kinase Mapped by LD-proxy IEA
BAD BCL2-associated agonist of cell death Mapped by significant region TAS
API5 apoptosis inhibitor 5 Mapped by PBA pathway IEA
BRMS1 breast cancer metastasis suppressor 1 Mapped by significant region IEA
CDIP1 cell death-inducing p53 target 1 Mapped by significant region IGI[17599062]
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 Mapped by CNV; Mapped by significant region IEP[12673577]
TRAF1 TNF receptor-associated factor 1 Mapped by significant region IEA
GJA1 gap junction protein, alpha 1, 43kDa Mapped by Literature SNP; Mapped by significant region IEA
C11orf82 chromosome 11 open reading frame 82 Mapped by significant region IEA
MAPK7 mitogen-activated protein kinase 7 Mapped by significant region IEA
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 Mapped by significant region TAS[11030628]
SHF Src homology 2 domain containing F Mapped by CNV IEA
UBB ubiquitin B Mapped by significant region TAS
CASP4 caspase 4, apoptosis-related cysteine peptidase Mapped by significant region IEA
APC adenomatous polyposis coli Mapped by LD-proxy; Mapped by PBA pathway TAS
TRAF7 TNF receptor-associated factor 7, E3 ubiquitin protein ligase Mapped by significant region IDA[15001576]
CARD6 caspase recruitment domain family, member 6 Mapped by significant region IEA
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A Mapped by significant region IEA
KMT2A lysine (K)-specific methyltransferase 2A Mapped by significant region IEA
DSG2 desmoglein 2 Mapped by significant region IDA[17559062]; TAS
G2E3 G2/M-phase specific E3 ubiquitin protein ligase Mapped by significant region IEA
CYFIP2 cytoplasmic FMR1 interacting protein 2 Mapped by significant region IDA[10449408]
DSG1 desmoglein 1 Mapped by significant region TAS
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV IDA[18371312]; IPI[7954800]
RNF144B ring finger protein 144B Mapped by LD-proxy IEA
MAPT microtubule-associated protein tau Mapped by LD-proxy; Mapped by PBA pathway TAS
ZBTB16 zinc finger and BTB domain containing 16 Mapped by significant region NAS[9294197]
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) Mapped by LD-proxy NAS[12054647]
DSG3 desmoglein 3 Mapped by significant region TAS
PDCD7 programmed cell death 7 Mapped by PBA pathway IEA
ATG5 autophagy related 5 Mapped by CNV IEA
PDCD10 programmed cell death 10 Mapped by CNV IEA
GATA6 GATA binding protein 6 Mapped by significant region IEA
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Mapped by significant region TAS
BFAR bifunctional apoptosis regulator Mapped by significant region IEA
BCL2L11 BCL2-like 11 (apoptosis facilitator) Mapped by LD-proxy TAS
OPA1 optic atrophy 1 (autosomal dominant) Mapped by CNV IEA
CASP1 caspase 1, apoptosis-related cysteine peptidase Mapped by significant region TAS[7876192]
BIRC6 baculoviral IAP repeat containing 6 Mapped by CNV IEA
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) Mapped by significant region NAS[2402757]
PERP PERP, TP53 apoptosis effector Mapped by significant region IEA
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region TAS
PDCL3 phosducin-like 3 Mapped by CNV IEA
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) Mapped by significant region IEA
RTN4 reticulon 4 Mapped by CNV NAS[11126360]
MIEN1 migration and invasion enhancer 1 Mapped by LD-proxy IEA
BLID BH3-like motif containing, cell death inducer Mapped by significant region IEA
BCL7C B-cell CLL/lymphoma 7C Mapped by CNV IEA
DAP death-associated protein Mapped by significant region IGI[7828849]
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Mapped by PBA pathway TAS
AXIN1 axin 1 Mapped by significant region IEA
EGLN3 egl-9 family hypoxia-inducible factor 3 Mapped by Literature SNP IEP
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Mapped by significant region TAS
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region TAS
MRPS30 mitochondrial ribosomal protein S30 Mapped by significant region TAS[10640817]
SMNDC1 survival motor neuron domain containing 1 Mapped by PBA pathway IEA
ADORA2A adenosine A2a receptor Mapped by CNV TAS[7818494]
CADM1 cell adhesion molecule 1 Mapped by significant region IEA
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 Mapped by significant region TAS
CXCR2 chemokine (C-X-C motif) receptor 2 Mapped by significant region IEA
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Mapped by significant region TAS
MAP1S microtubule-associated protein 1S Mapped by PBA pathway IDA[12762840]
RNF130 ring finger protein 130 Mapped by CNV IEA
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) Mapped by significant region TAS
LITAF lipopolysaccharide-induced TNF factor Mapped by significant region IEA
DNASE1 deoxyribonuclease I Mapped by significant region IEA
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV TAS
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 Mapped by CNV IEA
RTN3 reticulon 3 Mapped by significant region IEA
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 Mapped by significant region TAS
TAOK2 TAO kinase 2 Mapped by CNV NAS[10660600]
FADD Fas (TNFRSF6)-associated via death domain Mapped by significant region TAS
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy IEA
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 Mapped by significant region TAS
EMC4 ER membrane protein complex subunit 4 Mapped by CNV IEA
TGFBR1 transforming growth factor, beta receptor 1 Mapped by significant region IEA
PDIA2 protein disulfide isomerase family A, member 2 Mapped by significant region IMP[12095988]
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 Mapped by significant region IEA
NEK6 NIMA-related kinase 6 Mapped by significant region IEA
EI24 etoposide induced 2.4 Mapped by significant region IEA
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 Mapped by significant region IMP[17599062]; TAS
ARF6 ADP-ribosylation factor 6 Mapped by PBA pathway IEA
KLF11 Kruppel-like factor 11 Mapped by significant region IEA
GSN gelsolin Mapped by significant region; Mapped by PBA pathway TAS
DAXX death-domain associated protein Mapped by PBA pathway TAS[15572661]
ERN2 endoplasmic reticulum to nucleus signaling 2 Mapped by significant region IEA