ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005089
Name Rho guanyl-nucleotide exchange factor activity
Type molecular function
No. of Genes in ADHDgene  12
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 12)

Literature-origin genes (count: 4)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DOCK10 dedicator of cytokinesis 10 2q36.3 1(0/0/1) IEA
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1) IEA
NET1 neuroepithelial cell transforming 1 10p15 1(1/0/0) IEA
TRIO trio Rho guanine nucleotide exchange factor 5p14-p15.1 1(0/0/1) IEA

Genes from other sources Help (count: 8)

Approved Symbol Approved Name Source Evidence[PMID]
FGD3 FYVE, RhoGEF and PH domain containing 3 Mapped by significant region IEA
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region IEA
MCF2L MCF.2 cell line derived transforming sequence-like Mapped by CNV IEA
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17 Mapped by significant region IEA
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 Mapped by CNV; Mapped by significant region NAS
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B Mapped by significant region IEA
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like Mapped by PBA pathway IEA
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 Mapped by PBA pathway IDA[9857026]