ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TRDMT1
Previous Symbol	DNMT2
Symbol Alias	RNMT1
Approved Name	tRNA aspartic acid methyltransferase 1
Previous Name	DNA (cytosine-5-)-methyltransferase 2
Location	10p15.1
Position	chr10:17184253-17244070, -
External Links	HGNC: 2977 Entrez Gene: 1787 Ensembl: ENSG00000107614 UCSC: uc001iop.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_132	chr10:17129948-17242840 (NCBI Build 35 (hg17))	112893	10p13	Duplication	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008033	tRNA processing	Biological Process		11
GO:0090116	C-5 methylation of cytosine	Biological Process	TAS[9425235]	1
GO:0001975	response to amphetamine	Biological Process		16
GO:0003723	RNA binding	Molecular Function		104
GO:0003677	DNA binding	Molecular Function		220
GO:0005634	nucleus	Cellular Component		770
GO:0003886	DNA (cytosine-5-)-methyltransferase activity	Molecular Function	TAS[9425235]	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00270	Cysteine and methionine metabolism	1	Cysteine and methionine are sulfur-containing amino acids. C...... Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034]. More...

Genes shared at least 5 GO terms with TRDMT1 (count: 0)

Genes shared at least 2 KEGG pathways with TRDMT1 (count: 0)

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Region: chr10:17184253..17244070 View in gBrowse