ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SYP
Approved Name	synaptophysin
Location	Xp11.23-p11.22
Position	chrX:49044265-49056718, -
External Links	HGNC: 11506 Entrez Gene: 6855 Ensembl: ENSG00000102003 UCSC: uc004dmz.1
No. of Studies	3 (significant: 3; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 3)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Brookes K, 2006	UNPHASED TDT P-value=0.045, global P-value=0.038; OR=1.25, one or more SNPs with nominal P-value<0.05 located in this gene	Significant
Brookes KJ, 2005 (b)	1 SNP remained significant following case-control and TDT analysis of the individually genotyped data	Significant
Guan L, 2009	1 SNP in this gene achieved significance for ADHD-I in single SNP association analysis.	Significant

Gene related SNPs (count: 4)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs5906754	ChrX:49060227(Fwd)	downstream_gene_variant; upstream_gene_variant	2(2/0/0)
rs2293945	ChrX:49047619(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	1(1/0/0)

rs_ID	Location	Functional Annotation
rs5905722	ChrX:49051624(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs3817678	ChrX:49047325(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044306	neuron projection terminus	Cellular Component		1
GO:0043234	protein complex	Cellular Component		45
GO:0042802	identical protein binding	Molecular Function		70
GO:0042734	presynaptic membrane	Cellular Component		15
GO:0048786	presynaptic active zone	Cellular Component		4
GO:0048499	synaptic vesicle membrane organization	Biological Process	NAS[10620806]	1
GO:0048172	regulation of short-term neuronal synaptic plasticity	Biological Process		2
GO:0048169	regulation of long-term neuronal synaptic plasticity	Biological Process		4
GO:0017075	syntaxin-1 binding	Molecular Function		8
GO:0016188	synaptic vesicle maturation	Biological Process	NAS[10620806]	1
GO:0015485	cholesterol binding	Molecular Function	IDA[10620806]	10
GO:0006897	endocytosis	Biological Process		23
GO:0042169	SH2 domain binding	Molecular Function		7
GO:0032403	protein complex binding	Molecular Function		27
GO:0030285	integral to synaptic vesicle membrane	Cellular Component	NAS[1975480]	1
GO:0030054	cell junction	Cellular Component		77
GO:0005215	transporter activity	Molecular Function		41
GO:0005509	calcium ion binding	Molecular Function		124
GO:0060076	excitatory synapse	Cellular Component		3
GO:0071310	cellular response to organic substance	Biological Process		3
GO:2000474	regulation of opioid receptor signaling pathway	Biological Process		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SYP (count: 1)

Gene Symbol	Pathway Count	Pathway List
SYT1	7	identical protein binding; presynaptic membrane; syntaxin-1 binding; cell junction; transporter activity; calcium ion binding; excitatory synapse;

Genes shared at least 2 KEGG pathways with SYP (count: 0)

View in gBrowse

Region: chrX:49044265..49056718 View in gBrowse