ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SEC23A
Approved Name	Sec23 homolog A (S. cerevisiae)
Previous Name	"Sec23 (S. cerevisiae) homolog A"
Location	14q21.1
Position	chr14:39501123-39578850, -1
External Links	HGNC: 10701 Entrez Gene: 10484 Ensembl: ENSG00000100934 UCSC: uc001wup.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 7)

Literature-origin SNPs (count: 0)

LD-proxies (count: 7)

rs_ID	Location	Functional Annotation
rs4902402	chr14:39579628(Fwd)	downstream_gene_variant; upstream_gene_variant
rs10149829	chr14:39556693(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs6571896	chr14:39578134(Fwd)	downstream_gene_variant; intron_variant
rs2038357	chr14:39573063(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs6571891	chr14:39534909(Fwd)	intron_variant; nc_transcript_variant
rs6571890	chr14:39534764(Fwd)	intron_variant; nc_transcript_variant
rs2415525	chr14:39514989(Fwd)	intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0005829	cytosol	cellular component	TAS	485
GO:0030868	smooth endoplasmic reticulum membrane	cellular component	IEA	1
GO:0044267	cellular protein metabolic process	biological process	TAS	78
GO:0000139	Golgi membrane	cellular component	IEA	106
GO:0005515	protein binding	molecular function	IPI[18692470]	1015
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	99
GO:0005783	endoplasmic reticulum	cellular component	TAS[8898360]	111
GO:0043687	post-translational protein modification	biological process	TAS	42
GO:0005789	endoplasmic reticulum membrane	cellular component	TAS	159
GO:0030127	COPII vesicle coat	cellular component	IEA	1
GO:0018279	protein N-linked glycosylation via asparagine	biological process	TAS	27
GO:0016192	vesicle-mediated transport	biological process	TAS[8898360]	33
GO:0006886	intracellular protein transport	biological process	IEA	45
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	biological process	TAS	18
GO:0016044	cellular membrane organization	biological process	TAS	25
GO:0012507	ER to Golgi transport vesicle membrane	cellular component	TAS	6
GO:0006888	ER to Golgi vesicle-mediated transport	biological process	TAS	26
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	18
GO:0048208	COPII vesicle coating	biological process	TAS	4

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SEC23A (count: 19)

Gene Symbol	Pathway Count	Pathway List
LMAN1	8	cellular protein metabolic process; Golgi membrane; protein binding; post-translational protein modification; endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine; ER to Golgi transport vesicle membrane; ER to Golgi vesicle-mediated transport;
CANX	8	cellular protein metabolic process; protein binding; endoplasmic reticulum; post-translational protein modification; endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I;
ALG2	6	cellular protein metabolic process; protein binding; perinuclear region of cytoplasm; post-translational protein modification; endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine;
PDIA3	6	cellular protein metabolic process; protein binding; endoplasmic reticulum; post-translational protein modification; protein N-linked glycosylation via asparagine; antigen processing and presentation of peptide antigen via MHC class I;
STX18	6	Golgi membrane; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular protein transport; ER to Golgi vesicle-mediated transport;
TMED10	6	protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular protein transport; ER to Golgi vesicle-mediated transport; COPII vesicle coating;
TMED2	6	protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; intracellular protein transport; ER to Golgi vesicle-mediated transport; COPII vesicle coating;
PARK2	5	zinc ion binding; cytosol; protein binding; perinuclear region of cytoplasm; endoplasmic reticulum;
SYVN1	5	zinc ion binding; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine;
MAN2A2	5	zinc ion binding; cellular protein metabolic process; Golgi membrane; post-translational protein modification; protein N-linked glycosylation via asparagine;
ZW10	5	cytosol; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi vesicle-mediated transport;
STX4	5	cytosol; protein binding; perinuclear region of cytoplasm; intracellular protein transport; cellular membrane organization;
RAB14	5	cytosol; Golgi membrane; protein binding; perinuclear region of cytoplasm; vesicle-mediated transport;
COPB1	5	cytosol; Golgi membrane; protein binding; intracellular protein transport; cellular membrane organization;
STT3A	5	cellular protein metabolic process; protein binding; post-translational protein modification; endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine;
MAN1A1	5	cellular protein metabolic process; Golgi membrane; endoplasmic reticulum; post-translational protein modification; protein N-linked glycosylation via asparagine;
ALG1	5	cellular protein metabolic process; endoplasmic reticulum; post-translational protein modification; endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine;
SREBF1	5	Golgi membrane; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane;
TAPBP	5	Golgi membrane; protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; antigen processing and presentation of peptide antigen via MHC class I;

Genes shared at least 2 KEGG pathways with SEC23A (count: 0)

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Region: chr14:39501123..39578850 View in gBrowse