ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PARN
Symbol Alias	DAN
Approved Name	poly(A)-specific ribonuclease
Previous Name	"poly(A)-specific ribonuclease (deadenylation nuclease)"
Name Alias	"deadenylation nuclease"
Location	16p13
Position	chr16:14529558-14726585, -1
External Links	HGNC: 8609 Entrez Gene: 5073 Ensembl: ENSG00000140694 UCSC: uc010uzd.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13	chr16:0-16800000	3 (2/1/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0010467	gene expression	biological process	TAS	154
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0005515	protein binding	molecular function	IPI	1015
GO:0005737	cytoplasm	cellular component	TAS[9736620]	781
GO:0005829	cytosol	cellular component	TAS	485
GO:0004518	nuclease activity	molecular function	TAS[9736620]	3
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	biological process	TAS	9
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0009451	RNA modification	biological process	TAS[9736620]	1
GO:0004535	poly(A)-specific ribonuclease activity	molecular function	TAS	2
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	biological process	TAS	5
GO:0005634	nucleus	cellular component	TAS[9736620]	877
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0090305	nucleic acid phosphodiester bond hydrolysis	biological process	TAS[9736620]	2
GO:0000166	nucleotide binding	molecular function	IEA	83
GO:0005730	nucleolus	cellular component	IEA	271
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	biological process	IMP	23
GO:0007292	female gamete generation	biological process	TAS[9736620]	3
GO:0019901	protein kinase binding	molecular function	IPI	59
GO:0003730	mRNA 3'-UTR binding	molecular function	TAS[9736620]	10

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PARN (count: 103)

Gene Symbol	Pathway Count	Pathway List
RNPS1	10	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus; mRNA metabolic process; nucleotide binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; mRNA 3'-UTR binding;
CNOT6	10	gene expression; metal ion binding; protein binding; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; poly(A)-specific ribonuclease activity; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; mRNA metabolic process;
DCPS	9	gene expression; protein binding; cytoplasm; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; nucleus; mRNA metabolic process; nucleolus;
SMG1	9	gene expression; metal ion binding; protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS3	9	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; protein kinase binding;
TNKS1BP1	8	gene expression; cytoplasm; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; mRNA metabolic process;
RPS9	8	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process; nucleolus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RQCD1	8	gene expression; protein binding; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; nuclear-transcribed mRNA poly(A) tail shortening; nucleus; mRNA metabolic process;
PAIP1	8	gene expression; protein binding; cytoplasm; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; nuclear-transcribed mRNA poly(A) tail shortening; mRNA metabolic process;
SMG7	8	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL35	7	gene expression; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process; nucleolus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
NCBP1	7	gene expression; protein binding; cytosol; RNA metabolic process; nucleus; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL14	7	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS2	7	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; nucleolus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
HSPA8	7	gene expression; protein binding; cytosol; RNA metabolic process; nucleus; mRNA metabolic process; nucleolus;
RPS10	7	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; nucleolus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
XPO1	7	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process; nucleolus;
RPS25	7	gene expression; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process; nucleolus; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
PSMC3	7	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus; mRNA metabolic process;
DDX6	6	gene expression; protein binding; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; mRNA metabolic process;
DGCR8	6	gene expression; metal ion binding; protein binding; cytoplasm; nucleus; nucleolus;
HNRNPH1	6	gene expression; protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus;
PATL1	6	gene expression; protein binding; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; mRNA metabolic process;
HNRNPA2B1	6	gene expression; protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus;
GEMIN2	6	gene expression; protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus;
RPL37	6	gene expression; metal ion binding; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL13	6	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPL27A	6	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
RPS15A	6	gene expression; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
MEN1	6	gene expression; protein binding; cytoplasm; cytosol; nucleus; nucleolus;
FUS	6	gene expression; protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus;
LSM4	6	gene expression; protein binding; cytosol; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; RNA metabolic process; mRNA metabolic process;
IARS	6	gene expression; protein binding; cytoplasm; cytosol; nucleus; nucleolus;
RPL37A	6	gene expression; metal ion binding; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
PPP1CA	6	metal ion binding; protein binding; cytoplasm; cytosol; nucleus; nucleolus;
ALKBH8	6	metal ion binding; protein binding; cytoplasm; cytosol; nucleus; nucleolus;
DNAJA3	6	metal ion binding; protein binding; cytoplasm; cytosol; nucleus; protein kinase binding;
GSK3B	6	protein binding; cytoplasm; cytosol; nucleus; nucleolus; protein kinase binding;
IGF2BP3	6	protein binding; cytoplasm; cytosol; nucleus; nucleotide binding; mRNA 3'-UTR binding;
RBM4	6	protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus; mRNA 3'-UTR binding;
PDCD4	6	protein binding; cytoplasm; cytosol; RNA metabolic process; nucleus; nucleolus;
RPL12	5	gene expression; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
DHX9	5	gene expression; protein binding; cytoplasm; nucleus; nucleolus;
RPL3L	5	gene expression; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
PSMD7	5	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process;
PSMB7	5	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process;
PSME1	5	gene expression; cytoplasm; cytosol; RNA metabolic process; mRNA metabolic process;
SRP19	5	gene expression; cytoplasm; cytosol; nucleus; nucleolus;
PGR	5	gene expression; protein binding; cytoplasm; nucleus; nucleolus;
RPL38	5	gene expression; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
FAU	5	gene expression; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
SNRPD1	5	gene expression; protein binding; cytosol; RNA metabolic process; nucleus;
UBB	5	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process;
YAP1	5	gene expression; protein binding; cytoplasm; cytosol; nucleus;
CLNS1A	5	gene expression; protein binding; cytosol; RNA metabolic process; nucleus;
NEDD4L	5	gene expression; protein binding; cytoplasm; cytosol; nucleus;
MAML1	5	gene expression; protein binding; nucleus; nucleolus; protein kinase binding;
RBPJ	5	gene expression; protein binding; cytoplasm; nucleus; nucleolus;
PSMD5	5	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process;
UBC	5	gene expression; protein binding; cytosol; RNA metabolic process; mRNA metabolic process;
SMC1A	5	gene expression; protein binding; cytoplasm; nucleus; nucleolus;
EFTUD2	5	gene expression; protein binding; cytoplasm; nucleus; nucleolus;
PSMA8	5	gene expression; cytosol; RNA metabolic process; nucleus; mRNA metabolic process;
KARS	5	gene expression; metal ion binding; cytoplasm; cytosol; nucleus;
HNRNPA1	5	gene expression; cytoplasm; nucleus; nucleotide binding; nucleolus;
MAPK3	5	gene expression; protein binding; cytosol; nucleus; nucleolus;
SSRP1	5	gene expression; protein binding; cytoplasm; nucleus; nucleolus;
U2AF1	5	gene expression; protein binding; nucleus; nucleotide binding; nucleolus;
RPS12	5	gene expression; cytosol; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;
KAT5	5	metal ion binding; protein binding; cytosol; nucleus; nucleolus;
NUBP2	5	metal ion binding; protein binding; cytoplasm; nucleus; nucleotide binding;
PRKD1	5	metal ion binding; protein binding; cytoplasm; cytosol; nucleus;
PDE2A	5	metal ion binding; protein binding; cytoplasm; cytosol; nucleus;
NUBP1	5	metal ion binding; protein binding; cytoplasm; cytosol; nucleotide binding;
CRYAB	5	metal ion binding; protein binding; cytoplasm; cytosol; nucleus;
ID2	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
PRC1	5	protein binding; cytoplasm; nucleus; nucleolus; protein kinase binding;
MRE11A	5	protein binding; nuclease activity; nucleus; nucleic acid phosphodiester bond hydrolysis; nucleolus;
STXBP3	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
CIRBP	5	protein binding; cytoplasm; nucleus; nucleotide binding; mRNA 3'-UTR binding;
CEP164	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
RELA	5	protein binding; cytoplasm; cytosol; nucleus; protein kinase binding;
PAFAH1B1	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
PARK2	5	protein binding; cytoplasm; cytosol; nucleus; protein kinase binding;
MAPK1	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
BAIAP2	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
PSPC1	5	protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus;
RAD9A	5	protein binding; cytoplasm; nucleus; nucleolus; protein kinase binding;
SART1	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
MALT1	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
TDP2	5	protein binding; cytoplasm; nuclease activity; nucleus; nucleolus;
AIP	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
DAXX	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
CEP57	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
AKAP7	5	protein binding; cytosol; RNA metabolic process; nucleus; protein kinase binding;
WWOX	5	protein binding; cytoplasm; cytosol; nucleus; nucleotide binding;
NUMA1	5	protein binding; cytoplasm; cytosol; nucleus; nucleolus;
AXIN1	5	protein binding; cytoplasm; cytosol; nucleus; protein kinase binding;
CHD1L	5	protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus;
NOL8	5	protein binding; cytoplasm; nucleus; nucleotide binding; nucleolus;
ATXN2	5	protein binding; cytoplasm; RNA metabolic process; nucleus; nucleolus;
APC	5	protein binding; cytoplasm; cytosol; nucleus; protein kinase binding;
SOCS1	5	protein binding; cytoplasm; cytosol; nucleus; protein kinase binding;

Genes shared at least 2 KEGG pathways with PARN (count: 0)

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Region: chr16:14529558..14726585 View in gBrowse