ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MGRN1
Symbol Alias	KIAA0544, RNF156
Approved Name	mahogunin ring finger 1, E3 ubiquitin protein ligase
Previous Name	"mahogunin, ring finger 1"
Location	16p13
Position	chr16:4666494-4740975, 1
External Links	HGNC: 20254 Entrez Gene: 23295 Ensembl: ENSG00000102858 UCSC: uc002cxa.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13	chr16:0-16800000	3 (2/1/0)
16p13.3	chr16:0-7900000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005886	plasma membrane	cellular component	IDA[19737927]; IEA	839
GO:0008270	zinc ion binding	molecular function	IEA	367
GO:0005829	cytosol	cellular component	IEA	485
GO:0005737	cytoplasm	cellular component	IDA[19737927]	781
GO:0006513	protein monoubiquitination	biological process	IMP[17229889]	3
GO:0008333	endosome to lysosome transport	biological process	IMP[17229889]	6
GO:0005769	early endosome	cellular component	IDA[17229889]	27
GO:0005515	protein binding	molecular function	IPI[19737927]	1015
GO:0043951	negative regulation of cAMP-mediated signaling	biological process	IDA[19737927]	2
GO:0000209	protein polyubiquitination	biological process	IEA	26
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA[19737927]	60
GO:0005634	nucleus	cellular component	IDA[19737927]	877
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway	biological process	IDA[19737927]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34

Genes shared at least 5 GO terms with MGRN1 (count: 43)

Gene Symbol	Pathway Count	Pathway List
PARK2	8	zinc ion binding; cytosol; cytoplasm; protein monoubiquitination; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity; nucleus;
CBL	7	plasma membrane; zinc ion binding; cytosol; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
AXIN1	6	plasma membrane; cytosol; cytoplasm; protein binding; protein polyubiquitination; nucleus;
MALT1	6	plasma membrane; cytosol; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
SNCA	6	plasma membrane; zinc ion binding; cytosol; cytoplasm; protein binding; nucleus;
RNF40	6	plasma membrane; zinc ion binding; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
TNFAIP3	6	zinc ion binding; cytosol; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
TRIM32	6	zinc ion binding; cytoplasm; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity; nucleus;
BIRC2	6	zinc ion binding; cytosol; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity; nucleus;
ARRB1	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
CTNND1	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
TJP1	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
PDE2A	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
APC	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
WWOX	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
AIP	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
GSK3B	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
BAIAP2	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
PRKD1	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
STXBP3	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
CRYAB	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
NF2	5	plasma membrane; cytoplasm; early endosome; protein binding; nucleus;
ARRB2	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
LPXN	5	plasma membrane; zinc ion binding; cytoplasm; protein binding; nucleus;
NCK1	5	plasma membrane; cytosol; cytoplasm; protein binding; nucleus;
BIRC3	5	zinc ion binding; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
RNF20	5	zinc ion binding; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity; nucleus;
RCHY1	5	zinc ion binding; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
BARD1	5	zinc ion binding; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
LRSAM1	5	zinc ion binding; cytoplasm; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity;
RNF31	5	zinc ion binding; cytoplasm; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity;
RNF146	5	zinc ion binding; cytosol; protein binding; ubiquitin-protein ligase activity; nucleus;
HERC2	5	zinc ion binding; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
CCS	5	zinc ion binding; cytosol; cytoplasm; protein binding; nucleus;
TRIM5	5	zinc ion binding; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
BLMH	5	cytosol; cytoplasm; protein binding; protein polyubiquitination; nucleus;
HERC5	5	cytosol; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
MAPK1	5	cytosol; cytoplasm; early endosome; protein binding; nucleus;
NEDD4L	5	cytosol; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
UBE3A	5	cytosol; cytoplasm; protein binding; ubiquitin-protein ligase activity; nucleus;
STUB1	5	cytosol; cytoplasm; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity;
PSMC3	5	cytosol; cytoplasm; protein binding; protein polyubiquitination; nucleus;
PRPF19	5	cytoplasm; protein binding; protein polyubiquitination; ubiquitin-protein ligase activity; nucleus;

Genes shared at least 2 KEGG pathways with MGRN1 (count: 0)

View in gBrowse

Region: chr16:4666494..4740975 View in gBrowse