ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ADCY9
Symbol Alias	AC9
Approved Name	adenylate cyclase 9
Location	16p13.3
Position	chr16:4003388-4166186, -1
External Links	HGNC: 240 Entrez Gene: 115 Ensembl: ENSG00000162104 UCSC: uc002cvx.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p13	chr16:0-16800000	3 (2/1/0)
16p13.3	chr16:0-7900000	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway	biological process	TAS	11
GO:0006833	water transport	biological process	TAS	9
GO:0034199	activation of protein kinase A activity	biological process	TAS	5
GO:0004016	adenylate cyclase activity	molecular function	IEA	4
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0005886	plasma membrane	cellular component	TAS	839
GO:0007202	activation of phospholipase C activity	biological process	TAS	15
GO:0055085	transmembrane transport	biological process	TAS	95
GO:0005887	integral to plasma membrane	cellular component	TAS[9628827]	236
GO:0046872	metal ion binding	molecular function	IEA	200
GO:0007173	epidermal growth factor receptor signaling pathway	biological process	TAS	32
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS	51
GO:0007268	synaptic transmission	biological process	TAS	103
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	biological process	TAS	10
GO:0035556	intracellular signal transduction	biological process	IEA	52
GO:0007165	signal transduction	biological process	TAS	189
GO:0008543	fibroblast growth factor receptor signaling pathway	biological process	TAS	33
GO:0071377	cellular response to glucagon stimulus	biological process	TAS	9
GO:0006112	energy reserve metabolic process	biological process	TAS	31
GO:0005524	ATP binding	molecular function	IEA	265

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene
hsa00230	Purine metabolism	27
hsa05110	Vibrio cholerae infection	11
hsa04540	Gap junction	30
hsa04916	Melanogenesis	18
hsa04912	GnRH signaling pathway	30
hsa04020	Calcium signaling pathway	66

Genes shared at least 5 GO terms with ADCY9 (count: 26)

Gene Symbol	Pathway Count	Pathway List
ADCY3	20	adenylate cyclase-activating G-protein coupled receptor signaling pathway; water transport; activation of protein kinase A activity; adenylate cyclase activity; small molecule metabolic process; plasma membrane; activation of phospholipase C activity; transmembrane transport; integral to plasma membrane; metal ion binding; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; synaptic transmission; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; intracellular signal transduction; signal transduction; fibroblast growth factor receptor signaling pathway; cellular response to glucagon stimulus; energy reserve metabolic process; ATP binding;
ADCY2	19	adenylate cyclase-activating G-protein coupled receptor signaling pathway; water transport; activation of protein kinase A activity; adenylate cyclase activity; small molecule metabolic process; plasma membrane; activation of phospholipase C activity; transmembrane transport; metal ion binding; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; synaptic transmission; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; intracellular signal transduction; signal transduction; fibroblast growth factor receptor signaling pathway; cellular response to glucagon stimulus; energy reserve metabolic process; ATP binding;
ADCY4	19	adenylate cyclase-activating G-protein coupled receptor signaling pathway; water transport; activation of protein kinase A activity; adenylate cyclase activity; small molecule metabolic process; plasma membrane; activation of phospholipase C activity; transmembrane transport; metal ion binding; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; synaptic transmission; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; intracellular signal transduction; signal transduction; fibroblast growth factor receptor signaling pathway; cellular response to glucagon stimulus; energy reserve metabolic process; ATP binding;
PRKAR2B	13	water transport; activation of protein kinase A activity; small molecule metabolic process; plasma membrane; activation of phospholipase C activity; transmembrane transport; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; intracellular signal transduction; signal transduction; fibroblast growth factor receptor signaling pathway; cellular response to glucagon stimulus; energy reserve metabolic process;
ITPR2	8	small molecule metabolic process; plasma membrane; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; fibroblast growth factor receptor signaling pathway; energy reserve metabolic process;
ITPR1	7	small molecule metabolic process; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; fibroblast growth factor receptor signaling pathway; energy reserve metabolic process;
ADRBK1	7	plasma membrane; activation of phospholipase C activity; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; fibroblast growth factor receptor signaling pathway; ATP binding;
PDPK1	7	plasma membrane; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; synaptic transmission; intracellular signal transduction; fibroblast growth factor receptor signaling pathway; ATP binding;
GNAL	6	adenylate cyclase-activating G-protein coupled receptor signaling pathway; plasma membrane; metal ion binding; synaptic transmission; adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway; signal transduction;
GNG10	6	small molecule metabolic process; plasma membrane; synaptic transmission; signal transduction; cellular response to glucagon stimulus; energy reserve metabolic process;
PRKD1	6	small molecule metabolic process; plasma membrane; integral to plasma membrane; metal ion binding; signal transduction; ATP binding;
GSK3B	6	plasma membrane; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; intracellular signal transduction; fibroblast growth factor receptor signaling pathway; ATP binding;
MAPK1	6	epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; synaptic transmission; signal transduction; fibroblast growth factor receptor signaling pathway; ATP binding;
SMPD2	5	small molecule metabolic process; plasma membrane; integral to plasma membrane; metal ion binding; nerve growth factor receptor signaling pathway;
PIK3R1	5	small molecule metabolic process; plasma membrane; epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway;
CACNA1A	5	small molecule metabolic process; plasma membrane; metal ion binding; synaptic transmission; energy reserve metabolic process;
GNG3	5	small molecule metabolic process; plasma membrane; synaptic transmission; cellular response to glucagon stimulus; energy reserve metabolic process;
ADRA2A	5	small molecule metabolic process; plasma membrane; integral to plasma membrane; signal transduction; energy reserve metabolic process;
CHRM3	5	small molecule metabolic process; plasma membrane; integral to plasma membrane; signal transduction; energy reserve metabolic process;
CACNA1C	5	small molecule metabolic process; plasma membrane; metal ion binding; synaptic transmission; energy reserve metabolic process;
VAMP2	5	small molecule metabolic process; plasma membrane; integral to plasma membrane; synaptic transmission; energy reserve metabolic process;
CACNA1E	5	small molecule metabolic process; plasma membrane; metal ion binding; synaptic transmission; energy reserve metabolic process;
GABRB3	5	plasma membrane; transmembrane transport; integral to plasma membrane; synaptic transmission; signal transduction;
GABRA5	5	plasma membrane; transmembrane transport; integral to plasma membrane; synaptic transmission; signal transduction;
ITK	5	activation of phospholipase C activity; metal ion binding; intracellular signal transduction; signal transduction; ATP binding;
RPS6KB2	5	epidermal growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; fibroblast growth factor receptor signaling pathway; ATP binding;

Genes shared at least 2 KEGG pathways with ADCY9 (count: 24)

Gene Symbol	Pathway Count	Pathway List
ADCY3	6	Purine metabolism; Vibrio cholerae infection; Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ADCY4	5	Purine metabolism; Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ADCY2	5	Purine metabolism; Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
PLCB2	4	Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
PLCB3	4	Gap junction; Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
ITPR1	3	Gap junction; GnRH signaling pathway; Calcium signaling pathway;
ITPR2	3	Gap junction; GnRH signaling pathway; Calcium signaling pathway;
MAPK3	3	Gap junction; Melanogenesis; GnRH signaling pathway;
MAPK1	3	Gap junction; Melanogenesis; GnRH signaling pathway;
CAMK2D	3	Melanogenesis; GnRH signaling pathway; Calcium signaling pathway;
GUCY1A2	2	Purine metabolism; Gap junction;
TJP1	2	Vibrio cholerae infection; Gap junction;
PLCG2	2	Vibrio cholerae infection; Calcium signaling pathway;
GRM5	2	Gap junction; Calcium signaling pathway;
ADRB1	2	Gap junction; Calcium signaling pathway;
DRD1	2	Gap junction; Calcium signaling pathway;
HTR2A	2	Gap junction; Calcium signaling pathway;
MAPK7	2	Gap junction; GnRH signaling pathway;
HTR2C	2	Gap junction; Calcium signaling pathway;
GRM1	2	Gap junction; Calcium signaling pathway;
CACNA1D	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1C	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1S	2	GnRH signaling pathway; Calcium signaling pathway;
CACNA1F	2	GnRH signaling pathway; Calcium signaling pathway;

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Region: chr16:4003388..4166186 View in gBrowse